Discover the Most-Read Organic/Inorganic Chemistry Articles of June 2018

There are lots of different ways to look at the reach of an article. You can look at citations, Altmetric Attention Scores, awards, and more. One way to consider the influence of an article is just by looking at how many people chose to read it. To that end, we’ve compiled lists of the five most-read chemistry articles that appeared in each ACS Publications journal in June 2018, including research, reviews, perspectives and editorial pieces. These lists were not chosen by the journal’s editors and should not be taken as a “best of” list, but as another perspective on where the chemistry community allocated their attention.

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Read more of June’s most-read articles: Analytical | Applied | Biological | Materials Science & Engineering | Multidisciplinary | Organic/Inorganic | Physical
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ACS Catalysis

ACS Catalysis Goes to China
ACS Catal., 2018, 8 (6), pp 5636-5636
DOI: 10.1021/acscatal.8b01908

An Electrocatalytic Approach to the Radical Difunctionalization of Alkenes
ACS Catal., 2018, 8 (6), pp 5175-5187
DOI: 10.1021/acscatal.8b01069

Calculations of Product Selectivity in Electrochemical CO2 Reduction
Open access through ACS AuthorChoice
ACS Catal., 2018, 8 (6), pp 5240-5249
DOI: 10.1021/acscatal.7b03308

Catalytic Asymmetric Oxidative Enamine Transformations
ACS Catal., 2018, 8 (6), pp 5466-5484
DOI: 10.1021/acscatal.8b01263

Cobalt-Catalyzed Electrochemical Oxidative C-H/N-H Carbonylation with Hydrogen Evolution
ACS Catal., 2018, 8 (6), pp 5448-5453
DOI: 10.1021/acscatal.8b00683

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ACS Combinatorial Science

A Phenotypic Cell-Binding Screen Identifies a Novel Compound Targeting Triple-Negative Breast Cancer
ACS Comb. Sci., 2018, 20 (6), pp 330-334
DOI: 10.1021/acscombsci.8b00026

CsF-Catalyzed Transannulation Reaction of Oxazolones: Diastereoselective Synthesis of Diversified trans-N-(6-Oxo-1,4,5,6-tetrahydropyrimidin-5-yl)benzamides with Arylidene Azlactones and Amidines
ACS Comb. Sci., 2018, 20 (6), pp 358-365
DOI: 10.1021/acscombsci.8b00027

Current Parallel Solid-Phase Synthesis of Drug-like Oxadiazole and Thiadiazole Derivatives for Combinatorial Chemistry
ACS Comb. Sci., 2018, 20 (6), pp 309-329
DOI: 10.1021/acscombsci.8b00044

How Transparent Oxides Gain Some Color: Discovery of a CeNiO3 Reduced Bandgap Phase As an Absorber for Photovoltaics
ACS Comb. Sci., 2018, 20 (6), pp 366-376
DOI: 10.1021/acscombsci.8b00031

Issue Editorial Masthead
ACS Comb. Sci., 2018, 20 (6),
DOI: 10.1021/cov020i006_1195186

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ACS Medicinal Chemistry Letters

Chemical Proteomic Characterization of a Covalent KRASG12C Inhibitor
This article is part of the Med Chem Tech: Driving Drug Development special issue.
ACS Med. Chem. Lett., 2018, 9 (6), pp 557-562
DOI: 10.1021/acsmedchemlett.8b00110

Current Innovations in Medicinal Chemistry and Chemical Biology
This article is part of the Med Chem Tech: Driving Drug Development special issue.
ACS Med. Chem. Lett., 2018, 9 (6), pp 513-514
DOI: 10.1021/acsmedchemlett.8b00252

Development of Highly Potent and Selective Steroidal Inhibitors and Degraders of CDK8
This article is part of the Med Chem Tech: Driving Drug Development special issue.
ACS Med. Chem. Lett., 2018, 9 (6), pp 540-545
DOI: 10.1021/acsmedchemlett.8b00011

Expansion of cat-ELCCA for the Discovery of Small Molecule Inhibitors of the Pre-let-7-Lin28 RNA-Protein Interaction
Open access through ACS Editors’ Choice
This article is part of the Med Chem Tech: Driving Drug Development special issue.
ACS Med. Chem. Lett., 2018, 9 (6), pp 517-521
DOI: 10.1021/acsmedchemlett.8b00126

Homogeneous Assay for Target Engagement Utilizing Bioluminescent Thermal Shift
Open access through ACS AuthorChoice
This article is part of the Med Chem Tech: Driving Drug Development special issue.
ACS Med. Chem. Lett., 2018, 9 (6), pp 546-551
DOI: 10.1021/acsmedchemlett.8b00081

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Bioconjugate Chemistry

Combinatorially Screened Peptide as Targeted Covalent Binder: Alteration of Bait-Conjugated Peptide to Reactive Modifier
Bioconjugate Chem., 2018, 29 (6), pp 1866-1871
DOI: 10.1021/acs.bioconjchem.8b00301

Delivery of a Proapoptotic Peptide to EGFR-Positive Cancer Cells by a Cyclic Peptide Mimicking the Dimerization Arm Structure of EGFR
Bioconjugate Chem., 2018, 29 (6), pp 2050-2057
DOI: 10.1021/acs.bioconjchem.8b00250

Design and Development of Polysaccharide-Doxorubicin-Peptide Bioconjugates for Dual Synergistic Effects of Integrin-Targeted and Cell-Penetrating Peptides for Cancer Chemotherapy
Bioconjugate Chem., 2018, 29 (6), pp 1973-2000
DOI: 10.1021/acs.bioconjchem.8b00208

Enhanced DNA Binding and Photocleavage Abilities of β-Cyclodextrin Appended Ru(II) Complex through Supramolecular Strategy
Bioconjugate Chem., 2018, 29 (6), pp 1829-1833
DOI: 10.1021/acs.bioconjchem.8b00191

Fluorogenic Probing of Membrane Protein Trafficking
Bioconjugate Chem., 2018, 29 (6), pp 1823-1828
DOI: 10.1021/acs.bioconjchem.8b00180

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Inorganic Chemistry

Designing a Dy2 Single-Molecule Magnet with Two Well-Differentiated Relaxation Processes by Using a Nonsymmetric Bis-bidentate Bipyrimidine-N-Oxide Ligand: A Comparison with Mononuclear Counterparts
Inorg. Chem., 2018, 57 (11), pp 6362-6375
DOI: 10.1021/acs.inorgchem.8b00427

Hierarchical Two-Dimensional Conductive Metal-Organic Framework/Layered Double Hydroxide Nanoarray for a High-Performance Supercapacitor
Inorg. Chem., 2018, 57 (11), pp 6202-6205
DOI: 10.1021/acs.inorgchem.8b00493

High Pressure and High Temperature Synthesis of the Iron Pernitride FeN2
Inorg. Chem., 2018, 57 (11), pp 6245-6251
DOI: 10.1021/acs.inorgchem.7b03272

Hydride Conformers of the Nitrogenase FeMo-cofactor Two-Electron Reduced State E2(2H), Assigned Using Cryogenic Intra Electron Paramagnetic Resonance Cavity Photolysis
Open access through ACS Editors’ Choice
Inorg. Chem., 2018, 57 (12), pp 6847-6852
DOI: 10.1021/acs.inorgchem.8b00271

Magnetic Metal-Organic Framework Exhibiting Quick and Selective Solvatochromic Behavior along with Reversible Crystal-to-Amorphous-to-Crystal Transformation
Inorg. Chem., 2018, 57 (12), pp 7006-7014
DOI: 10.1021/acs.inorgchem.8b00703

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Journal of Medicinal Chemistry

Design of Small Molecule Autophagy Modulators: A Promising Druggable Strategy
J. Med. Chem., 2018, 61 (11), pp 4656-4687
DOI: 10.1021/acs.jmedchem.7b01019

Discovery of Highly Isoform Selective Orally Bioavailable Phosphoinositide 3-Kinase (PI3K)-γ Inhibitors
Open access through ACS Editors’ Choice
J. Med. Chem., 2018, 61 (12), pp 5435-5441
DOI: 10.1021/acs.jmedchem.8b00447

Discovery of Novel Dual Mechanism of Action Src Signaling and Tubulin Polymerization Inhibitors (KX2-391 and KX2-361)
Open access through ACS Editors’ Choice
J. Med. Chem., 2018, 61 (11), pp 4704-4719
DOI: 10.1021/acs.jmedchem.8b00164

Discovery of Orally Bioavailable, Quinoline-Based Aldehyde Dehydrogenase 1A1 (ALDH1A1) Inhibitors with Potent Cellular Activity
Open access through ACS AuthorChoice
J. Med. Chem., 2018, 61 (11), pp 4883-4903
DOI: 10.1021/acs.jmedchem.8b00270

Fragment-Based Discovery of a Potent, Orally Bioavailable Inhibitor That Modulates the Phosphorylation and Catalytic Activity of ERK1/2
J. Med. Chem., 2018, 61 (11), pp 4978-4992
DOI: 10.1021/acs.jmedchem.8b00421

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Journal of Natural Products

Chloramphenicol Derivatives with Antibacterial Activity Identified by Functional Metagenomics
J. Nat. Prod., 2018, 81 (6), pp 1321-1332
DOI: 10.1021/acs.jnatprod.7b00903

Evodialones A and B: Polyprenylated Acylcyclopentanone Racemates with a 3-Ethyl-1,1-diisopentyl-4-methylcyclopentane Skeleton from Evodia lepta
J. Nat. Prod., 2018, 81 (6), pp 1483-1487
DOI: 10.1021/acs.jnatprod.7b00993

Iridoids from the Roots of Patrinia scabra and Their Inhibitory Potential on LPS-Induced Nitric Oxide Production
J. Nat. Prod., 2018, 81 (6), pp 1468-1473
DOI: 10.1021/acs.jnatprod.8b00229

Isolation, Synthesis, and Semisynthesis of Amaryllidaceae Constituents from Narcissus and Galanthus sp.: De Novo Total Synthesis of 2-epi-Narciclasine
J. Nat. Prod., 2018, 81 (6), pp 1451-1459
DOI: 10.1021/acs.jnatprod.8b00218

Jizanpeptins, Cyanobacterial Protease Inhibitors from a Symploca sp. Cyanobacterium Collected in the Red Sea
Open access through ACS Editors’ Choice
J. Nat. Prod., 2018, 81 (6), pp 1417-1425
DOI: 10.1021/acs.jnatprod.8b00117

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The Journal of Organic Chemistry

Bidirectional Synthesis of Di-tert-butyl (2S,6S,8S)- and (2R,6R,8R)-1,7-Diazaspiro[5.5]undecane-2,8-dicarboxylate and Related Spirodiamines
J. Org. Chem., 2018, 83 (12), pp 6783-6787
DOI: 10.1021/acs.joc.8b00794

Design, Synthesis, and Isomerization Studies of Light-Driven Molecular Motors for Single Molecular Imaging
Open access through ACS AuthorChoice
J. Org. Chem., 2018, 83 (11), pp 6025-6034
DOI: 10.1021/acs.joc.8b00654

Enantioselective Halolactonization Reactions using BINOL-Derived Bifunctional Catalysts: Methodology, Diversification, and Applications
J. Org. Chem., 2018, 83 (11), pp 5954-5968
DOI: 10.1021/acs.joc.8b00490

Enantioselective Synthesis of 2-Amino-1,1-diarylalkanes Bearing a Carbocyclic Ring Substituted Indole through Asymmetric Catalytic Reaction of Hydroxyindoles with Nitroalkenes
J. Org. Chem., 2018, 83 (12), pp 6397-6407
DOI: 10.1021/acs.joc.8b00612

Evolution of a Strategy for the Enantioselective Total Synthesis of (+)-Psiguadial B
J. Org. Chem., 2018, 83 (11), pp 6066-6085
DOI: 10.1021/acs.joc.8b00728

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Molecular Pharmaceutics

Chemoproteomic Profiling Reveals Ethacrynic Acid Targets Adenine Nucleotide Translocases to Impair Mitochondrial Function
Mol. Pharmaceutics, 2018, 15 (6), pp 2413-2422
DOI: 10.1021/acs.molpharmaceut.8b00250

Co-Stabilization of Amorphous Pharmaceuticals-The Case of Nifedipine and Nimodipine
Mol. Pharmaceutics, 2018, 15 (6), pp 2455-2465
DOI: 10.1021/acs.molpharmaceut.8b00308

Digesting a Path Forward: The Utility of Collagenase Tumor Treatment for Improved Drug Delivery
Mol. Pharmaceutics, 2018, 15 (6), pp 2069-2083
DOI: 10.1021/acs.molpharmaceut.8b00319

Inhibition of Human Amylin Aggregation and Cellular Toxicity by Lipoic Acid and Ascorbic Acid
Mol. Pharmaceutics, 2018, 15 (6), pp 2098-2106
DOI: 10.1021/acs.molpharmaceut.7b01009

Intracellular Drug Bioavailability: Effect of Neutral Lipids and Phospholipids
Open access through ACS AuthorChoice
Mol. Pharmaceutics, 2018, 15 (6), pp 2224-2233
DOI: 10.1021/acs.molpharmaceut.8b00064

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Organic Letters

A Practical and Chemoselective Ammonia-Free Birch Reduction
Org. Lett., 2018, 20 (12), pp 3439-3442
DOI: 10.1021/acs.orglett.8b00891

A Total Synthesis of (−)-Hamigeran B and (−)-4-Bromohamigeran B
Org. Lett., 2018, 20 (12), pp 3687-3690
DOI: 10.1021/acs.orglett.8b01490

An Unexpected FeCl3-Catalyzed Cascade Reaction of Indoles and o-Hydroxychalcones for the Assembly of Chromane-Bridged Polycyclic Indoles
Org. Lett., 2018, 20 (12), pp 3451-3454
DOI: 10.1021/acs.orglett.8b01107

Catalyst-Free Aminomethylamination of o-Hydroxystyrenes with Aminals to 1,3-Diamines
Org. Lett., 2018, 20 (12), pp 3601-3604
DOI: 10.1021/acs.orglett.8b01383

Merging “Anti-Baldwin” 3-Exo-Dig Cyclization with 1,2-Alkynyl Migration for Radical Alkylalkynylation of Unactivated Olefins
Org. Lett., 2018, 20 (12), pp 3596-3600
DOI: 10.1021/acs.orglett.8b01382

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Organic Process Research & Development

Bis(1,2,4-oxadiazole)bis(methylene) Dinitrate: A High-Energy Melt-Castable Explosive and Energetic Propellant Plasticizing Ingredient
Org. Process Res. Dev., 2018, 22 (6), pp 736-740
DOI: 10.1021/acs.oprd.8b00076

Continuous Production of Anhydrous tert-Butyl Hydroperoxide in Nonane Using Membrane Pervaporation and Its Application in Flow Oxidation of a γ-Butyrolactam
Open access through ACS Editors’ Choice
Org. Process Res. Dev., 2018, 22 (6), pp 707-720
DOI: 10.1021/acs.oprd.8b00083

Cooling Crystallization of Indomethacin: Effect of Supersaturation, Temperature, and Seeding on Polymorphism and Crystal Size Distribution
Org. Process Res. Dev., 2018, 22 (6), pp 697-706
DOI: 10.1021/acs.oprd.8b00078

Development of a Safe and High-Throughput Continuous Manufacturing Approach to 4-(2-Hydroxyethyl)thiomorpholine 1,1-Dioxide
Org. Process Res. Dev., 2018, 22 (6), pp 721-727
DOI: 10.1021/acs.oprd.8b00100

Effective Utilization of Flow Chemistry: Use of Unstable Intermediates, Inhibition of Side Reactions, and Scale-Up for Boronic Acid Synthesis
Org. Process Res. Dev., 2018, 22 (6), pp 741-746
DOI: 10.1021/acs.oprd.8b00118

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Organometallics

CO2/Epoxide Coupling and the ROP of ε-Caprolactone: Mg and Al Complexes of γ-Phosphino-ketiminates as Dual-Purpose Catalysts
Organometallics, 2018, 37 (11), pp 1656-1664
DOI: 10.1021/acs.organomet.8b00017

Computational Analysis of the Intramolecular Oxidative Amination of an Alkene Catalyzed by the Extreme π-Loading N-Heterocyclic Carbene Pincer Tantalum(V) Bis(imido) Complex
Organometallics, 2018, 37 (11), pp 1671-1681
DOI: 10.1021/acs.organomet.8b00097

Markovnikov at Gold: Nucleophilic Addition to Alkenes at Au(III)
Organometallics, 2018, 37 (12), pp 1937-1947
DOI: 10.1021/acs.organomet.8b00218

Neutral Bis(imino)-1,4-dihydropyridinate and Cationic Bis(imino)pyridine σ-Alkylzinc(II) Complexes as Hydride Exchange Systems: Classic Organometallic Chemistry Meets Ligand-Centered, Biomimetic Reactivity
Organometallics, 2018, 37 (11), pp 1734-1744
DOI: 10.1021/acs.organomet.8b00183

Nuances in Fundamental Suzuki-Miyaura Cross-Couplings Employing [Pd(PPh3)4]: Poor Reactivity of Aryl Iodides at Lower Temperatures
Open access through ACS Editors’ Choice
Organometallics, 2018, 37 (11), pp 1745-1750
DOI: 10.1021/acs.organomet.8b00189

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