Chemistry plays a central role in the advancement of modern medicine. Although chemistry has long been the foundation for the discovery and development of therapeutics, its contributions to the fight against disease are continually expanding. From research on nutraceuticals and functional foods that provides a foundation of knowledge for the promotion of health and reduction […]
Chemistry plays a central role in the advancement of modern medicine. Although chemistry has long been the foundation for the discovery and development of therapeutics, its contributions to the fight against disease are continually expanding. From research on nutraceuticals and functional foods that provides a foundation of knowledge for the promotion of health and reduction of risk for chronic diseases, to the development of nanoparticles for targeted drug delivery and molecular imaging, chemistry’s reach affects the prevention, diagnosis and treatment of disease.
To supplement the exciting presentations in the “Bench to Bedside: Chemistry of Health Care” technical symposium to be held at PACIFICHEM, ACS Publications has assembled a collection of articles that highlight the diverse contributions of chemistry to health care. The collection includes a number of articles on subjects including small molecule therapeutics, drug conjugates, drug delivery systems, imaging, tissue engineering, and functional foods. We hope you enjoy the collection and continue to support efforts to move chemistry from bench to bedside and beyond.
ACS Biomaterials Science & Engineering
Macromolecular and Inorganic Nanomaterials Scaffolds for Carbon Monoxide Delivery: Recent Developments and Future Trends
Diep Nguyen and Cyrille Boyer
ACS Biomaterials Science & Engineering 2015 1 (10), 895-913
DOI: 10.1021/acsbiomaterials.5b00230
Initial Cell Adhesion on Well-Defined Surface by Polymer Brush Layers with Varying Chemical Structures
Kazuhiko Ishihara, Tomomi Kitagawa, and Yuuki Inoue
ACS Biomaterials Science & Engineering 2015 1 (2), 103-109
ACS Infectious Diseases
Inhibiting the β-Lactamase of Mycobacterium tuberculosis (Mtb) with Novel Boronic Acid Transition-State Inhibitors (BATSIs)
Sebastian G. Kurz, Saugata Hazra, Christopher R. Bethel, Chiara Romagnoli, Emilia Caselli, Fabio Prati, John S. Blanchard, and Robert A. Bonomo
ACS Infectious Diseases 2015 1 (6), 234-242
DOI: 10.1021/acsinfecdis.5b00003
Phosphorylation of BlaR1 in Manifestation of Antibiotic Resistance in Methicillin-Resistant Staphylococcus aureus and Its Abrogation by Small Molecules
Marc A. Boudreau, Jennifer Fishovitz, Leticia I. Llarrull, Qiaobin Xiao, and Shahriar Mobashery
ACS Infectious Diseases 2015 1 (10), 454-459
DOI: 10.1021/acsinfecdis.5b00086
ACS Macro Letters
Generating Better Medicines for Cancer
Stuart S. Dunn, James D. Byrne, Jillian L. Perry, Kai Chen, and Joseph M. DeSimone
ACS Medicinal Chemistry Letters
Effectively Delivering a Unique Hsp90 Inhibitor Using Star Polymers
Seong Jong Kim, Deborah M. Ramsey, Cyrille Boyer, Thomas P. Davis, and Shelli R. McAlpine
ACS Medicinal Chemistry Letters 2013 4 (10), 915-920
Discovery and Development of Potent and Selective Inhibitors of Histone Methyltransferase G9a
Ramzi F. Sweis, Marina Pliushchev, Peter J. Brown, Jun Guo, Fengling Li, David Maag, Andrew M. Petros, Nirupama B. Soni, Chris Tse, Masoud Vedadi, Michael R. Michaelides, Gary G. Chiang, and William N. Pappano
ACS Medicinal Chemistry Letters 2014 5 (2), 205-209
Biomacromolecules
Oligonucleotide Immobilization and Hybridization on Aldehyde Functionalized Poly(2-Hydroxyethyl Methacrylate) Brushes
Tugba Bilgic and Harm-Anton Klok
Biomacromolecules 2015 16 (11), 3657-3665
DOI: 10.1021/acs.biomac.5b01116
Imine Hydrogels with Tunable Degradability for Tissue Engineering
Natalie Boehnke, Cynthia Cam, Erhan Bat, Tatiana Segura, and Heather D. Maynard
Biomacromolecules 2015 16 (7), 2101-2108
DOI: 10.1021/acs.biomac.5b00519
Drug Carriers for the Delivery of Therapeutic Peptides
Alice W. Du and Martina H. Stenzel
Biomacromolecules 2014 15 (4), 1097-1114
Chemical Research in Toxicology
Nanotoxicity of Silver Nanoparticles to Red Blood Cells: Size Dependent Adsorption, Uptake, and Hemolytic Activity
Li Qiang Chen, Li Fang, Jian Ling, Cheng Zhi Ding, Bin Kang, and Cheng Zhi Huang
Chemical Research in Toxicology 2015 28 (3), 501-509
Inorganic Chemistry
Rational Design of a Cytotoxic Dinuclear Cu2 Complex That Binds by Molecular Recognition at Two Neighboring Phosphates of the DNA Backbone
Thomas Jany, Alexander Moreth, Claudia Gruschka, Andy Sischka, Andre Spiering, Mareike Dieding, Ying Wang, Susan Haji Samo, Anja Stammler, Hartmut Bögge, Gabriele Fischer von Mollard, Dario Anselmetti, and Thorsten Glaser
Inorganic Chemistry 2015 54 (6), 2679-2690
Journal of Agricultural & Food Chemistry
Low Molecular Weight Phenolics of Grape Juice and Winemaking Byproducts: Antioxidant Activities and Inhibition of Oxidation of Human Low-Density Lipoprotein Cholesterol and DNA Strand Breakage
Adriano Costa de Camargo, Marisa Aparecida Bismara Regitano-d’Arce, Aline Camarão Telles Biasoto, and Fereidoon Shahidi
Journal of Agricultural and Food Chemistry 2014 62 (50), 12159-12171
Targeting Cancer Stem Cells in Breast Cancer: Potential Anticancer Properties of 6-Shogaol and Pterostilbene
Chi-Hao Wu, Bo-Han Hong, Chi-Tang Ho, and Gow-Chin Yen
Journal of Agricultural and Food Chemistry 2015 63 (9), 2432-2441
Journal of Medicinal Chemistry
Shuttle-Cargo Fusion Molecules of Transport Peptides and the hD(2/3) Receptor Antagonist Fallypride: A Feasible Approach To Preserve Ligand-Receptor Binding?
Carmen Wängler, Shafinaz Chowdhury, Georg Höfner, Petia Djurova, Enrico O. Purisima, Peter Bartenstein, Björn Wängler, Gert Fricker, Klaus T. Wanner, and Ralf Schirrmacher
Journal of Medicinal Chemistry 2014 57 (10), 4368-4381
Discovery of an in Vivo Chemical Probe of the Lysine Methyltransferases G9a and GLP
Feng Liu, Dalia Barsyte-Lovejoy, Fengling Li, Yan Xiong, Victoria Korboukh, Xi-Ping Huang, Abdellah Allali-Hassani, William P. Janzen, Bryan L. Roth, Stephen V. Frye, Cheryl H. Arrowsmith, Peter J. Brown, Masoud Vedadi, and Jian Jin
Journal of Medicinal Chemistry 2013 56 (21), 8931-8942
Molecular Pharmaceutics
Effective Delivery of siRNA into Cancer Cells and Tumors Using Well-Defined Biodegradable Cationic Star Polymers
Cyrille Boyer, Joann Teo, Phoebe Phillips, Rafael B. Erlich, Sharon Sagnella, George Sharbeen, Tanya Dwarte, Hien T. T. Duong, David Goldstein, Thomas P. Davis, Maria Kavallaris, and Joshua McCarroll
Molecular Pharmaceutics 2013 10 (6), 2435-2444
PET Imaging of Fatty Acid Amide Hydrolase with [F-18]DOPP in Nonhuman Primates
Benjamin H. Rotstein, Hsiao-Ying Wey, Timothy M. Shoup, Alan A. Wilson, Steven H. Liang, Jacob M. Hooker, and Neil Vasdev
Molecular Pharmaceutics 2014 11 (11), 3832-3838
Organometallics
Cytotoxicity and NMR Studies of Platinum Complexes with Cyclooctadiene Ligands
Mirja Enders, Benjamin Görling, Alexander B. Braun, Judith E. Seltenreich, Linus F. Reichenbach, Kari Rissanen, Martin Nieger, Burkhard Luy, Ute Schepers, and Stefan Bräse
Organometallics 2014 33 (15), 4027-4034
Organometallic Titanocene–Gold Compounds as Potential Chemotherapeutics in Renal Cancer. Study of their Protein Kinase Inhibitory Properties
Jacob Fernández-Gallardo, Benelita T. Elie, Florian J. Sulzmaier, Mercedes Sanaú, Joe W. Ramos, and María Contel
Organometallics 2014 33 (22), 6669-6681
