We’ve compiled lists of the five most-read biological chemistry articles across ACS journals in October 2018, including research, reviews, perspectives, and editorial pieces.

There are lots of different ways to look at the reach of an article. You can look at citations, Altmetric Attention Scores, awards, and more. One way to consider the influence of an article is just by looking at how many people chose to read it. To that end, we’ve compiled lists of the five most-read chemistry articles that appeared in each ACS Publications journal in October 2018, including research, reviews, perspectives, and editorial pieces. These lists were not chosen by the journal’s editors and should not be taken as a “best of” list, but as another perspective on where the chemistry community allocated their attention.

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Read more of October’s most-read articles: Analytical | Applied | Biological | Materials Science & Engineering | Multidisciplinary | Organic/Inorganic | Physical
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ACS Biomaterials Science & Engineering

Early Career Board Announcement
ACS Biomater. Sci. Eng., 2018, 4 (10), pp 3450–3450
DOI: 10.1021/acsbiomaterials.8b01125

Gelatin Hydrogel Combined with Polydopamine Coating To Enhance Tissue Integration of Medical Implants
ACS Biomater. Sci. Eng., 2018, 4 (10), pp 3471–3477
DOI: 10.1021/acsbiomaterials.8b00886

Biomimetic Bacterial Cellulose-Enhanced Double-Network Hydrogel with Excellent Mechanical Properties Applied for the Osteochondral Defect Repair
ACS Biomater. Sci. Eng., 2018, 4 (10), pp 3534–3544
DOI: 10.1021/acsbiomaterials.8b00682

Evaluation of Self-Assembled Glycopeptide Nanofibers Modified with N,N′-Diacetyllactosamine for Selective Galectin-3 Recognition and Inhibition
ACS Biomater. Sci. Eng., 2018, 4 (10), pp 3451–3459
DOI: 10.1021/acsbiomaterials.8b00611

Near-Infrared Light-Triggered Hydrophobic-to-Hydrophilic Switch Nanovalve for On-Demand Cancer Therapy
ACS Biomater. Sci. Eng., 2018, 4 (10), pp 3478–3486
DOI: 10.1021/acsbiomaterials.8b00437

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ACS Catalysis

Cu-Catalyzed Decarboxylative Borylation
ACS Catal., 2018, 8 (10), pp 9537–9542
DOI: 10.1021/acscatal.8b02928

Oxygen Evolution Reaction—The Enigma in Water Electrolysis
ACS Catal., 2018, 8 (10), pp 9765–9774
DOI: 10.1021/acscatal.8b02712

Heterogeneous Organocatalysis for Photoredox Chemistry
ACS Catal., 2018, 8 (10), pp 9790–9808
DOI: 10.1021/acscatal.8b02595

Effect of Saturating the Electrolyte with Oxygen on the Activity for the Oxygen Evolution Reaction
Open access through ACS AuthorChoice.
ACS Catal., 2018, 8 (10), pp 9359–9363
DOI: 10.1021/acscatal.8b01447

Ligand-Enabled, Palladium-Catalyzed β-C(sp3)–H Arylation of Weinreb Amides
ACS Catal., 2018, 8 (10), pp 9292–9297
DOI: 10.1021/acscatal.8b03014

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ACS Chemical Biology

Cell-Specific Chemical Delivery Using a Selective Nitroreductase–Nitroaryl Pair
Open access through ACS AuthorChoice.
ACS Chem. Biol., 2018, 13 (10), pp 2888–2896
DOI: 10.1021/acschembio.8b00524

Adversarial Controls for Scientific Machine Learning
ACS Chem. Biol., 2018, 13 (10), pp 2819–2821
DOI: 10.1021/acschembio.8b00881

Chemical Instability and Promiscuity of Arylmethylidenepyrazolinone-Based MDMX Inhibitors
Open access through ACS AuthorChoice.
ACS Chem. Biol., 2018, 13 (10), pp 2849–2854
DOI: 10.1021/acschembio.8b00665

Modulating PCAF/GCN5 Immune Cell Function through a PROTAC Approach
ACS Chem. Biol., 2018, 13 (10), pp 2862–2867
DOI: 10.1021/acschembio.8b00705

Combining Chemical Genetics with Proximity-Dependent Labeling Reveals Cellular Targets of Poly(ADP-ribose) Polymerase 14 (PARP14)
ACS Chem. Biol., 2018, 13 (10), pp 2841–2848
DOI: 10.1021/acschembio.8b00567

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ACS Chemical Neuroscience

Welcome to the DARK Side: DARK Classics in Chemical Neuroscience
ACS Chem. Neurosci., 2018, 9 (10), pp 2286–2286
DOI: 10.1021/acschemneuro.8b00528

Psychedelics and Personality
ACS Chem. Neurosci., 2018, 9 (10), pp 2304–2306
DOI: 10.1021/acschemneuro.8b00237

DARK Side of Amphetamine and Analogues: Pharmacology, Syndromic Manifestation, and Management of Amphetamine Addiction
ACS Chem. Neurosci., 2018, 9 (10), pp 2299–2303
DOI: 10.1021/acschemneuro.8b00137

Dark Classics in Chemical Neuroscience: Lysergic Acid Diethylamide (LSD)
This article is part of the “DARK Classics in Chemical Neuroscience” special issue.
ACS Chem. Neurosci., 2018, 9 (10), pp 2331–2343
DOI: 10.1021/acschemneuro.8b00043

The DARK Side of Total Synthesis: Strategies and Tactics in Psychoactive Drug Production
This article is part of the “DARK Classics in Chemical Neuroscience” special issue.
ACS Chem. Neurosci., 2018, 9 (10), pp 2307–2330
DOI: 10.1021/acschemneuro.7b00528

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ACS Infectious Diseases

Pharmacokinetics of β-Lactam Antibiotics: Clues from the Past To Help Discover Long-Acting Oral Drugs in the Future
ACS Infect. Dis., 2018, 4 (10), pp 1439–1447
DOI: 10.1021/acsinfecdis.8b00160

Noninvasive Urine Biomarker Lateral Flow Immunoassay for Monitoring Active Onchocerciasis
Open access through ACS AuthorChoice
ACS Infect. Dis., 2018, 4 (10), pp 1423–1431
DOI: 10.1021/acsinfecdis.8b00163

Development of Chemical Proteomics for the Folateome and Analysis of the Kinetoplastid Folateome
Open access through ACS AuthorChoice
ACS Infect. Dis., 2018, 4 (10), pp 1475–1486
DOI: 10.1021/acsinfecdis.8b00097

Getting Drugs into Gram-Negative Bacteria: Rational Rules for Permeation through General Porins
ACS Infect. Dis., 2018, 4 (10), pp 1487–1498
DOI: 10.1021/acsinfecdis.8b00108

Getting Drugs through Small Pores: Exploiting the Porins Pathway in Pseudomonas aeruginosa
ACS Infect. Dis., 2018, 4 (10), pp 1519–1528
DOI: 10.1021/acsinfecdis.8b00149

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ACS Medicinal Chemistry Letters

Decision Making in Medicinal Chemistry: The Power of Our Intuition
ACS Med. Chem. Lett., 2018, 9 (10), pp 956–958
DOI: 10.1021/acsmedchemlett.8b00359

Marine Natural Products in Medicinal Chemistry
ACS Med. Chem. Lett., 2018, 9 (10), pp 959–961
DOI: 10.1021/acsmedchemlett.8b00368

Drivers of Orphan Drug Development
ACS Med. Chem. Lett., 2018, 9 (10), pp 962–964
DOI: 10.1021/acsmedchemlett.8b00438

CCR4 Antagonists Inhibit Treg Trafficking into the Tumor Microenvironment
ACS Med. Chem. Lett., 2018, 9 (10), pp 953–955
DOI: 10.1021/acsmedchemlett.8b00351

NLRP3 Modulators for the Treatment of Autoinflammatory Disorders
ACS Med. Chem. Lett., 2018, 9 (10), pp 965–966
DOI: 10.1021/acsmedchemlett.8b00416

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ACS Synthetic Biology

A Genetically Encoded Biosensor for Monitoring Isoprene Production in Engineered Escherichia coli
ACS Synth. Biol., 2018, 7 (10), pp 2379–2390
DOI: 10.1021/acssynbio.8b00164

Discovering Selective Binders for Photoswitchable Proteins Using Phage Display
ACS Synth. Biol., 2018, 7 (10), pp 2355–2364
DOI: 10.1021/acssynbio.8b00123

Engineered Biosensors from Dimeric Ligand-Binding Domains
ACS Synth. Biol., 2018, 7 (10), pp 2457–2467
DOI: 10.1021/acssynbio.8b00242

Establishing a Cell-Free Vibrio natriegens Expression System
ACS Synth. Biol., 2018, 7 (10), pp 2475–2479
DOI: 10.1021/acssynbio.8b00222

A Genetically Encoded Protein Polymer for Uranyl Binding and Extraction Based on the SpyTag–SpyCatcher Chemistry
ACS Synth. Biol., 2018, 7 (10), pp 2331–2339
DOI: 10.1021/acssynbio.8b00223

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Biochemistry

Light at the End of the Amyloid Tunnel
This article is part of the “Biochemistry to Bedside” special issue.
Biochemistry, 2018, 57 (41), pp 5921–5922
DOI: 10.1021/acs.biochem.8b00985

Entry from the Lipid Bilayer: A Possible Pathway for Inhibition of a Peptide G Protein-Coupled Receptor by a Lipophilic Small Molecule
Biochemistry, 2018, 57 (39), pp 5748–5758
DOI: 10.1021/acs.biochem.8b00577

A Slick Solution to a Sticky Problem
Biochemistry, 2018, 57 (41), pp 5923–5924
DOI: 10.1021/acs.biochem.8b00916

Improved Chemical-Genetic Fluorescent Markers for Live Cell Microscopy
Biochemistry, 2018, 57 (39), pp 5648–5653
DOI: 10.1021/acs.biochem.8b00649

Retraction of “Structural Basis for Antagonism by Suramin of Heparin Binding to Vaccinia Complement Protein”
Biochemistry, 2018, 57 (41), pp 6043–6043
DOI: 10.1021/acs.biochem.8b00955

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Bioconjugate Chemistry

Hypoxia-Activated Anticancer Prodrug for Bioimaging, Tracking Drug Release, and Anticancer Application
Bioconjugate Chem., 2018, 29 (10), pp 3332–3343
DOI: 10.1021/acs.bioconjchem.8b00511

Selective Uptake Into Drug Resistant Mammalian Cancer by Cell Penetrating Peptide-Mediated Delivery
Bioconjugate Chem., 2018, 29 (10), pp 3273–3284
DOI: 10.1021/acs.bioconjchem.8b00429

Small Molecule Nanodrug Assembled of Dual-Anticancer Drug Conjugate for Synergetic Cancer Metastasis Therapy
Bioconjugate Chem., 2018, 29 (10), pp 3495–3502
DOI: 10.1021/acs.bioconjchem.8b00657

Peptide-Directed Photo-Cross-Linking for Site-Specific Conjugation of IgG
Bioconjugate Chem., 2018, 29 (10), pp 3240–3244
DOI: 10.1021/acs.bioconjchem.8b00515

Guide to Selecting a Biorecognition Element for Biosensors
Bioconjugate Chem., 2018, 29 (10), pp 3231–3239
DOI: 10.1021/acs.bioconjchem.8b00592

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Biomacromolecules

Design of Modular Polyhydroxyalkanoate Scaffolds for Protein Immobilization by Directed Ligation
Biomacromolecules, 2018, 19 (10), pp 4098–4112
DOI: 10.1021/acs.biomac.8b01093

Robust Polyion Complex Vesicles (PICsomes) under Physiological Conditions Reinforced by Multiple Hydrogen Bond Formation Derived by Guanidinium Groups
Biomacromolecules, 2018, 19 (10), pp 4113–4121
DOI: 10.1021/acs.biomac.8b01097

Nucleopore-Inspired Polymer Hydrogels for Selective Biomolecular Transport
Biomacromolecules, 2018, 19 (10), pp 3905–3916
DOI: 10.1021/acs.biomac.8b00556

New Generation of Clickable Nucleic Acids: Synthesis and Active Hybridization with DNA
Biomacromolecules, 2018, 19 (10), pp 4139–4146
DOI: 10.1021/acs.biomac.8b01164

Temperature-Dependent Complex Coacervation of Engineered Elastin-like Polypeptide and Hyaluronic Acid Polyelectrolytes
Biomacromolecules, 2018, 19 (10), pp 3925–3935
DOI: 10.1021/acs.biomac.8b00837

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Journal of Agricultural and Food Chemistry

Intestinal Signaling of Proteins and Digestion-Derived Products Relevant to Satiety
Open access through ACS Editors’ Choice
J. Agric. Food Chem., 2018, 66 (39), pp 10123–10131
DOI: 10.1021/acs.jafc.8b02355

Breakthroughs in the Health Effects of Plant Food Bioactives: A Perspective on Microbiomics, Nutri(epi)genomics, and Metabolomics
Open access through ACS AuthorChoice
J. Agric. Food Chem., 2018, 66 (41), pp 10686–10692
DOI: 10.1021/acs.jafc.8b03385

Rapid and Visual Detection of Benzoyl Peroxide in Food by a Colorimetric and Ratiometric Fluorescent Probe
J. Agric. Food Chem., 2018, 66 (41), pp 10913–10920
DOI: 10.1021/acs.jafc.8b04733

Targeting Tumor Metabolism with Plant-Derived Natural Products: Emerging Trends in Cancer Therapy
J. Agric. Food Chem., 2018, 66 (41), pp 10663–10685
DOI: 10.1021/acs.jafc.8b04104

Lipid-Lowering Effects of Medium-Chain Triglyceride-Enriched Coconut Oil in Combination with Licorice Extracts in Experimental Hyperlipidemic Mice
J. Agric. Food Chem., 2018, 66 (40), pp 10447–10457
DOI: 10.1021/acs.jafc.8b04080

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Journal of Chemical Theory and Computation

Metadynamics with Discriminants: A Tool for Understanding Chemistry
J. Chem. Theory Comput., 2018, 14 (10), pp 5040–5044
DOI: 10.1021/acs.jctc.8b00634

Tinker 8: Software Tools for Molecular Design
J. Chem. Theory Comput., 2018, 14 (10), pp 5273–5289
DOI: 10.1021/acs.jctc.8b00529

AARON: An Automated Reaction Optimizer for New Catalysts
J. Chem. Theory Comput., 2018, 14 (10), pp 5249–5261
DOI: 10.1021/acs.jctc.8b00578

Anomalous Effects of Velocity Rescaling Algorithms: The Flying Ice Cube Effect Revisited
J. Chem. Theory Comput., 2018, 14 (10), pp 5262–5272
DOI: 10.1021/acs.jctc.8b00446

Theoretical Study of Protein–Ligand Interactions Using the Molecules-in-Molecules Fragmentation-Based Method
J. Chem. Theory Comput., 2018, 14 (10), pp 5143–5155
DOI: 10.1021/acs.jctc.8b00531

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Journal of Medicinal Chemistry

Lowering Lipophilicity by Adding Carbon: One-Carbon Bridges of Morpholines and Piperazines
J. Med. Chem., 2018, 61 (19), pp 8934–8943
DOI: 10.1021/acs.jmedchem.8b01148

A Dual Inhibition, a Better Solution: Development of a JAK1/TYK2 inhibitor
J. Med. Chem., 2018, 61 (19), pp 8594–8596
DOI: 10.1021/acs.jmedchem.8b01397

Dual Inhibition of TYK2 and JAK1 for the Treatment of Autoimmune Diseases: Discovery of ((S)-2,2-Difluorocyclopropyl)((1R,5S)-3-(2-((1-methyl-1H-pyrazol-4-yl)amino)pyrimidin-4-yl)-3,8-diazabicyclo[3.2.1]octan-8-yl)methanone (PF-06700841)
J. Med. Chem., 2018, 61 (19), pp 8597–8612
DOI: 10.1021/acs.jmedchem.8b00917

Emerging Approaches for the Identification of Protein Targets of Small Molecules – A Practitioners’ Perspective
J. Med. Chem., 2018, 61 (19), pp 8504–8535
DOI: 10.1021/acs.jmedchem.7b01921

Structure-Based Drug Design and Identification of H2O-Soluble and Low Toxic Hexacyclic Camptothecin Derivatives with Improved Efficacy in Cancer and Lethal Inflammation Models in Vivo
J. Med. Chem., 2018, 61 (19), pp 8613–8624
DOI: 10.1021/acs.jmedchem.8b00498

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Journal of Natural Products

Bioactive Pentacyclic Triterpenes from the Root Bark Extract of Myrianthus arboreus, a Species Used Traditionally to Treat Type-2 Diabetes
J. Nat. Prod., 2018, 81 (10), pp 2169–2176
DOI: 10.1021/acs.jnatprod.8b00079

Auranthine, a Benzodiazepinone from Penicillium aurantiogriseum: Refined Structure, Absolute Configuration, and Cytotoxicity
J. Nat. Prod., 2018, 81 (10), pp 2177–2186
DOI: 10.1021/acs.jnatprod.8b00187

Irpeksins A–E, 1,10-seco-Eburicane-Type Triterpenoids from the Medicinal Fungus Irpex lacteus and Their Anti-NO Activity
J. Nat. Prod., 2018, 81 (10), pp 2163–2168
DOI: 10.1021/acs.jnatprod.7b00845

Structures and Antimutagenic Effects of Onoceranoid-Type Triterpenoids from the Leaves of Lansium domesticum
J. Nat. Prod., 2018, 81 (10), pp 2187–2194
DOI: 10.1021/acs.jnatprod.8b00341

Biotransformation of β-Mangostin by an Endophytic Fungus of Garcinia mangostana to Furnish Xanthenes with an Unprecedented Heterocyclic Skeleton
J. Nat. Prod., 2018, 81 (10), pp 2244–2250
DOI: 10.1021/acs.jnatprod.8b00519

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The Journal of Physical Chemistry B

Mechanical Softening of a Small Ubiquitin-Related Modifier Protein Due to Temperature Induced Flexibility at the Core
J. Phys. Chem. B, 2018, 122 (39), pp 9128–9136
DOI: 10.1021/acs.jpcb.8b06844

Dynamics of Disordered Proteins under Confinement: Memory Effects and Internal Friction
J. Phys. Chem. B, 2018, 122 (39), pp 9049–9060
DOI: 10.1021/acs.jpcb.8b06112

Scaling of Rates of Vibrational Energy Transfer in Proteins with Equilibrium Dynamics and Entropy
This article is part of the “Deciphering Molecular Complexity in Dynamics and Kinetics from the Single Molecule to the Single Cell Level” special issue.
J. Phys. Chem. B, 2018, 122 (40), pp 9331–9339
DOI: 10.1021/acs.jpcb.8b07552

Electronic Resonant Stimulated Raman Scattering Micro-Spectroscopy
This article is part of the “Young Scientists” special issue.
J. Phys. Chem. B, 2018, 122 (39), pp 9218–9224
DOI: 10.1021/acs.jpcb.8b07037

Enabling Computational Design of ZIFs Using ReaxFF
J. Phys. Chem. B, 2018, 122 (41), pp 9616–9624
DOI: 10.1021/acs.jpcb.8b08094

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The Journal of Physical Chemistry Letters

Top Selected Papers in the Physical Chemistry of Energy Materials 2016–2017
J. Phys. Chem. Lett., 2018, 9 (19), pp 5897–5905
DOI: 10.1021/acs.jpclett.8b02731

Nonadiabatic Excited-State Dynamics with Machine Learning
J. Phys. Chem. Lett., 2018, 9 (19), pp 5660–5663
DOI: 10.1021/acs.jpclett.8b02469

Computational Design of Thermally Activated Delayed Fluorescence Materials: The Challenges Ahead
J. Phys. Chem. Lett., 2018, 9 (20), pp 6149–6163
DOI: 10.1021/acs.jpclett.8b02327

Theory of the Double Layer in Water-in-Salt Electrolytes
J. Phys. Chem. Lett., 2018, 9 (19), pp 5840–5846
DOI: 10.1021/acs.jpclett.8b02543

All-Atom Molecular Dynamics Simulations of Whole Viruses
J. Phys. Chem. Lett., 2018, 9 (19), pp 5805–5809
DOI: 10.1021/acs.jpclett.8b02298

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Journal of Proteome Research

Single Muscle Fiber Proteomics Reveals Distinct Protein Changes in Slow and Fast Fibers during Muscle Atrophy
J. Proteome Res., 2018, 17 (10), pp 3333–3347
DOI: 10.1021/acs.jproteome.8b00093

Comparison of an Optimized Ultracentrifugation Method versus Size-Exclusion Chromatography for Isolation of Exosomes from Human Serum
J. Proteome Res., 2018, 17 (10), pp 3599–3605
DOI: 10.1021/acs.jproteome.8b00479

An Integrated, High-Throughput Strategy for Multiomic Systems Level Analysis
J. Proteome Res., 2018, 17 (10), pp 3396–3408
DOI: 10.1021/acs.jproteome.8b00302

Isoform-Level Interpretation of High-Throughput Proteomics Data Enabled by Deep Integration with RNA-seq
J. Proteome Res., 2018, 17 (10), pp 3431–3444
DOI: 10.1021/acs.jproteome.8b00310

Probing the Sensitivity of the Orbitrap Lumos Mass Spectrometer Using a Standard Reference Protein in a Complex Background
J. Proteome Res., 2018, 17 (10), pp 3586–3592
DOI: 10.1021/acs.jproteome.8b00269

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Molecular Pharmaceutics

Artificial Intelligence for Drug Discovery, Biomarker Development, and Generation of Novel Chemistry
Mol. Pharmaceutics, 2018, 15 (10), pp 4311–4313
DOI: 10.1021/acs.molpharmaceut.8b00930

Entangled Conditional Adversarial Autoencoder for de Novo Drug Discovery
Open access through ACS AuthorChoice
Mol. Pharmaceutics, 2018, 15 (10), pp 4398–4405
DOI: 10.1021/acs.molpharmaceut.8b00839

Adversarial Threshold Neural Computer for Molecular de Novo Design
Open access through ACS AuthorChoice
Mol. Pharmaceutics, 2018, 15 (10), pp 4386–4397
DOI: 10.1021/acs.molpharmaceut.7b01137

3D Molecular Representations Based on the Wave Transform for Convolutional Neural Networks
Open access through ACS AuthorChoice
Mol. Pharmaceutics, 2018, 15 (10), pp 4378–4385
DOI: 10.1021/acs.molpharmaceut.7b01134

Drug Repurposing Using Deep Embeddings of Gene Expression Profiles
Open access through ACS AuthorChoice
Mol. Pharmaceutics, 2018, 15 (10), pp 4314–4325
DOI: 10.1021/acs.molpharmaceut.8b00284

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