There are lots of different ways to look at the reach of an article. You can look at citations, Altmetric Attention Scores, awards, and more. One way to consider the influence of an article is just by looking at how many people chose to read it. To that end, we’ve compiled lists of the five […]

There are lots of different ways to look at the reach of an article. You can look at citations, Altmetric Attention Scores, awards, and more. One way to consider the influence of an article is just by looking at how many people chose to read it. To that end, we’ve compiled lists of the five most-read chemistry articles that appeared in each ACS Publications journal in October 2018, including research, reviews, perspectives, and editorial pieces. These lists were not chosen by the journal’s editors and should not be taken as a “best of” list, but as another perspective on where the chemistry community allocated their attention.

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Read more of October’s most-read articles: Analytical | Applied | Biological | Materials Science & Engineering | Multidisciplinary | Organic/Inorganic | Physical
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ACS Catalysis

Cu-Catalyzed Decarboxylative Borylation
ACS Catal., 2018, 8 (10), pp 9537–9542
DOI: 10.1021/acscatal.8b02928

Oxygen Evolution Reaction—The Enigma in Water Electrolysis
ACS Catal., 2018, 8 (10), pp 9765–9774
DOI: 10.1021/acscatal.8b02712

Heterogeneous Organocatalysis for Photoredox Chemistry
ACS Catal., 2018, 8 (10), pp 9790–9808
DOI: 10.1021/acscatal.8b02595

Effect of Saturating the Electrolyte with Oxygen on the Activity for the Oxygen Evolution Reaction
Open access through ACS AuthorChoice.
ACS Catal., 2018, 8 (10), pp 9359–9363
DOI: 10.1021/acscatal.8b01447

Ligand-Enabled, Palladium-Catalyzed β-C(sp3)–H Arylation of Weinreb Amides
ACS Catal., 2018, 8 (10), pp 9292–9297
DOI: 10.1021/acscatal.8b03014

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ACS Combinatorial Science

Competition-Enhanced Ligand Selection to Identify DNA Aptamers
ACS Comb. Sci., 2018, 20 (10), pp 585–593
DOI: 10.1021/acscombsci.8b00048

Ring-Opening of Indoles: An Unconventional Route for the Transformation of Indoles to 1H-Pyrazoles Using Lewis Acid
ACS Comb. Sci., 2018, 20 (10), pp 573–578
DOI: 10.1021/acscombsci.8b00071

Issue Editorial Masthead
ACS Comb. Sci., 2018, 20 (10),
DOI: 10.1021/cov020i010_1224796

Overcoming Site Heterogeneity In Search of Metal Nanocatalysts
ACS Comb. Sci., 2018, 20 (10), pp 567–572
DOI: 10.1021/acscombsci.8b00070

An Engineered Sso7d Variant Enables Efficient Magnetization of Yeast Cells
ACS Comb. Sci., 2018, 20 (10), pp 579–584
DOI: 10.1021/acscombsci.8b00084

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ACS Medicinal Chemistry Letters

Decision Making in Medicinal Chemistry: The Power of Our Intuition
ACS Med. Chem. Lett., 2018, 9 (10), pp 956–958
DOI: 10.1021/acsmedchemlett.8b00359

Marine Natural Products in Medicinal Chemistry
ACS Med. Chem. Lett., 2018, 9 (10), pp 959–961
DOI: 10.1021/acsmedchemlett.8b00368

Drivers of Orphan Drug Development
ACS Med. Chem. Lett., 2018, 9 (10), pp 962–964
DOI: 10.1021/acsmedchemlett.8b00438

CCR4 Antagonists Inhibit Treg Trafficking into the Tumor Microenvironment
ACS Med. Chem. Lett., 2018, 9 (10), pp 953–955
DOI: 10.1021/acsmedchemlett.8b00351

NLRP3 Modulators for the Treatment of Autoinflammatory Disorders
ACS Med. Chem. Lett., 2018, 9 (10), pp 965–966
DOI: 10.1021/acsmedchemlett.8b00416

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Bioconjugate Chemistry

Hypoxia-Activated Anticancer Prodrug for Bioimaging, Tracking Drug Release, and Anticancer Application
Bioconjugate Chem., 2018, 29 (10), pp 3332–3343
DOI: 10.1021/acs.bioconjchem.8b00511

Selective Uptake Into Drug Resistant Mammalian Cancer by Cell Penetrating Peptide-Mediated Delivery
Bioconjugate Chem., 2018, 29 (10), pp 3273–3284
DOI: 10.1021/acs.bioconjchem.8b00429

Small Molecule Nanodrug Assembled of Dual-Anticancer Drug Conjugate for Synergetic Cancer Metastasis Therapy
Bioconjugate Chem., 2018, 29 (10), pp 3495–3502
DOI: 10.1021/acs.bioconjchem.8b00657

Peptide-Directed Photo-Cross-Linking for Site-Specific Conjugation of IgG
Bioconjugate Chem., 2018, 29 (10), pp 3240–3244
DOI: 10.1021/acs.bioconjchem.8b00515

Guide to Selecting a Biorecognition Element for Biosensors
Bioconjugate Chem., 2018, 29 (10), pp 3231–3239
DOI: 10.1021/acs.bioconjchem.8b00592

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Inorganic Chemistry

Design and Synthesis of Porous Nickel(II) and Cobalt(II) Cages
Inorg. Chem., 2018, 57 (19), pp 11847–11850
DOI: 10.1021/acs.inorgchem.8b01130

Bioinorganic Chemistry of the Natural [Fe(NO)2] Motif: Evolution of a Functional Model for NO-Related Biomedical Application and Revolutionary Development of a Translational Model
Inorg. Chem., 2018, 57 (20), pp 12425–12443
DOI: 10.1021/acs.inorgchem.8b01818

Europium-Based Metal–Organic Framework as a Dual Luminescence Sensor for the Selective Detection of the Phosphate Anion and Fe3+ Ion in Aqueous Media
Inorg. Chem., 2018, 57 (19), pp 11855–11858
DOI: 10.1021/acs.inorgchem.8b02017

High Volumetric Hydrogen Adsorption in a Porous Anthracene-Decorated Metal–Organic Framework
Open access through ACS AuthorAccess.
Inorg. Chem., 2018, 57 (19), pp 12050–12055
DOI: 10.1021/acs.inorgchem.8b01607

Photoinduced Dynamics of Bis-dipyrrinato-palladium(II) and Porphodimethenato-palladium(II) Complexes: Governing Near Infrared Phosphorescence by Structural Restriction
Open access through ACS Editors’ Choice.
Inorg. Chem., 2018, 57 (20), pp 12480–12488
DOI: 10.1021/acs.inorgchem.8b00974

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Journal of Medicinal Chemistry

Lowering Lipophilicity by Adding Carbon: One-Carbon Bridges of Morpholines and Piperazines
J. Med. Chem., 2018, 61 (19), pp 8934–8943
DOI: 10.1021/acs.jmedchem.8b01148

A Dual Inhibition, a Better Solution: Development of a JAK1/TYK2 inhibitor
J. Med. Chem., 2018, 61 (19), pp 8594–8596
DOI: 10.1021/acs.jmedchem.8b01397

Dual Inhibition of TYK2 and JAK1 for the Treatment of Autoimmune Diseases: Discovery of ((S)-2,2-Difluorocyclopropyl)((1R,5S)-3-(2-((1-methyl-1H-pyrazol-4-yl)amino)pyrimidin-4-yl)-3,8-diazabicyclo[3.2.1]octan-8-yl)methanone (PF-06700841)
J. Med. Chem., 2018, 61 (19), pp 8597–8612
DOI: 10.1021/acs.jmedchem.8b00917

Emerging Approaches for the Identification of Protein Targets of Small Molecules – A Practitioners’ Perspective
J. Med. Chem., 2018, 61 (19), pp 8504–8535
DOI: 10.1021/acs.jmedchem.7b01921

Structure-Based Drug Design and Identification of H2O-Soluble and Low Toxic Hexacyclic Camptothecin Derivatives with Improved Efficacy in Cancer and Lethal Inflammation Models in Vivo
J. Med. Chem., 2018, 61 (19), pp 8613–8624
DOI: 10.1021/acs.jmedchem.8b00498

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Journal of Natural Products

Bioactive Pentacyclic Triterpenes from the Root Bark Extract of Myrianthus arboreus, a Species Used Traditionally to Treat Type-2 Diabetes
J. Nat. Prod., 2018, 81 (10), pp 2169–2176
DOI: 10.1021/acs.jnatprod.8b00079

Auranthine, a Benzodiazepinone from Penicillium aurantiogriseum: Refined Structure, Absolute Configuration, and Cytotoxicity
J. Nat. Prod., 2018, 81 (10), pp 2177–2186
DOI: 10.1021/acs.jnatprod.8b00187

Irpeksins A–E, 1,10-seco-Eburicane-Type Triterpenoids from the Medicinal Fungus Irpex lacteus and Their Anti-NO Activity
J. Nat. Prod., 2018, 81 (10), pp 2163–2168
DOI: 10.1021/acs.jnatprod.7b00845

Structures and Antimutagenic Effects of Onoceranoid-Type Triterpenoids from the Leaves of Lansium domesticum
J. Nat. Prod., 2018, 81 (10), pp 2187–2194
DOI: 10.1021/acs.jnatprod.8b00341

Biotransformation of β-Mangostin by an Endophytic Fungus of Garcinia mangostana to Furnish Xanthenes with an Unprecedented Heterocyclic Skeleton
J. Nat. Prod., 2018, 81 (10), pp 2244–2250
DOI: 10.1021/acs.jnatprod.8b00519

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The Journal of Organic Chemistry

Cyclic Hypervalent Iodine Reagents for Azidation: Safer Reagents and Photoredox-Catalyzed Ring Expansion
Open access through ACS Editors’ Choice.
J. Org. Chem., 2018, 83 (19), pp 12334–12356
DOI: 10.1021/acs.joc.8b02068

Asymmetric Rhodium-Catalyzed Allylic Substitution Reactions: Discovery, Development and Applications to Target-Directed Synthesis
J. Org. Chem., 2018, 83 (19), pp 11463–11479
DOI: 10.1021/acs.joc.8b00583

Total Synthesis of (+)-Pyrenolide D
J. Org. Chem., 2018, 83 (19), pp 12315–12319
DOI: 10.1021/acs.joc.8b02003

Synthesis of α-Arylated Cycloalkanones from Congested Trisubstituted Spiro-epoxides: Application of the House–Meinwald Rearrangement for Ring Expansion
J. Org. Chem., 2018, 83 (20), pp 12357–12373
DOI: 10.1021/acs.joc.8b01448

Site-Selective Conversion of Azido Groups at Carbonyl α-Positions to Diazo Groups in Diazido and Triazido Compounds
J. Org. Chem., 2018, 83 (19), pp 12103–12121
DOI: 10.1021/acs.joc.8b02074

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Molecular Pharmaceutics

Artificial Intelligence for Drug Discovery, Biomarker Development, and Generation of Novel Chemistry
Mol. Pharmaceutics, 2018, 15 (10), pp 4311–4313
DOI: 10.1021/acs.molpharmaceut.8b00930

Entangled Conditional Adversarial Autoencoder for de Novo Drug Discovery
Open access through ACS AuthorChoice
Mol. Pharmaceutics, 2018, 15 (10), pp 4398–4405
DOI: 10.1021/acs.molpharmaceut.8b00839

Adversarial Threshold Neural Computer for Molecular de Novo Design
Open access through ACS AuthorChoice
Mol. Pharmaceutics, 2018, 15 (10), pp 4386–4397
DOI: 10.1021/acs.molpharmaceut.7b01137

3D Molecular Representations Based on the Wave Transform for Convolutional Neural Networks
Open access through ACS AuthorChoice
Mol. Pharmaceutics, 2018, 15 (10), pp 4378–4385
DOI: 10.1021/acs.molpharmaceut.7b01134

Drug Repurposing Using Deep Embeddings of Gene Expression Profiles
Open access through ACS AuthorChoice
Mol. Pharmaceutics, 2018, 15 (10), pp 4314–4325
DOI: 10.1021/acs.molpharmaceut.8b00284

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Organic Letters

Development and Utilization of a Palladium-Catalyzed Dehydration of Primary Amides To Form Nitriles
Open access through ACS AuthorChoice.
Org. Lett., 2018, 20 (19), pp 6046–6050
DOI: 10.1021/acs.orglett.8b02422

Minisci-Photoredox-Mediated α-Heteroarylation of N-Protected Secondary Amines: Remarkable Selectivity of Azetidines
Org. Lett., 2018, 20 (19), pp 6003–6006
DOI: 10.1021/acs.orglett.8b00991

Diastereoselective Synthesis of Tetrahydroquinolines via [4 + 2] Annulation between in Situ Generated p-Quinone Methides and Nitroalkenes
Org. Lett., 2018, 20 (19), pp 5995–5998
DOI: 10.1021/acs.orglett.8b02127

Toward the Total Synthesis of Ryanodol via Oxidative Alkyne–1,3-Diketone Annulation: Construction of a Ryanoid Tetracycle
Open access through ACS Editors’ Choice.
Org. Lett., 2018, 20 (20), pp 6457–6461
DOI: 10.1021/acs.orglett.8b02767

Well-Defined Phosphine-Free Iron-Catalyzed N-Ethylation and N-Methylation of Amines with Ethanol and Methanol
Org. Lett., 2018, 20 (19), pp 5985–5990
DOI: 10.1021/acs.orglett.8b02080

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Organic Process Research & Development

Some Items of Interest to Process R&D Chemists and Engineers
Org. Process Res. Dev., 2018, 22 (10), pp 1335–1343
DOI: 10.1021/acs.oprd.8b00320

The First Kilogram Synthesis of Beclabuvir, an HCV NS5B Polymerase Inhibitor
Org. Process Res. Dev., 2018, 22 (10), pp 1393–1408
DOI: 10.1021/acs.oprd.8b00214

Evaluating the Impact of a Decade of Funding from the Green Chemistry Institute Pharmaceutical Roundtable
Org. Process Res. Dev., 2018, 22 (10), pp 1344–1359
DOI: 10.1021/acs.oprd.8b00237

Development of a Synthesis of Kinase Inhibitor AKN028
Org. Process Res. Dev., 2018, 22 (10), pp 1360–1364
DOI: 10.1021/acs.oprd.8b00092

Scalable Process for the Production of a Highly Energetic Bromoacetylene Building Block
Org. Process Res. Dev., 2018, 22 (10), pp 1409–1418
DOI: 10.1021/acs.oprd.8b00223

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Organometalics

Pitfalls in Computational Modeling of Chemical Reactions and How To Avoid Them
Organometallics, 2018, 37 (19), pp 3228–3239
DOI: 10.1021/acs.organomet.8b00456

Let’s Talk About Safety: Open Communication for Safer Laboratories
Organometallics, 2018, 37 (19), pp 3225–3227
DOI: 10.1021/acs.organomet.8b00627

Improved Synthesis of [CpRRhCl2]2 Complexes
Organometallics, 2018, 37 (19), pp 3240–3242
DOI: 10.1021/acs.organomet.8b00400

Ernesto Carmona: Organometallic Chemistry Pioneer in Southern Europe—A Biographical Outline
Organometallics, 2018, 37 (20), pp 3379–3384
DOI: 10.1021/acs.organomet.8b00643

Reductive Elimination to Form C(sp3)–N Bonds from Palladium(II) Primary Alkyl Complexes
Organometallics, 2018, 37 (19), pp 3243–3247
DOI: 10.1021/acs.organomet.8b00617

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