There are lots of different ways to look at the reach of an article. You can look at citations, Altmetric Attention Scores, awards, and more. One way to consider the influence of an article is just by looking at how many people chose to read it. To that end, we’ve compiled lists of the five most-read chemistry articles that appeared in each ACS Publications journal in 2018, including research, reviews, perspectives, and editorial pieces. These lists were not chosen by the journal’s editors and should not be taken as a “best of” list, but as another perspective on where the chemistry community allocated their attention over the past year.
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Read more of 2018’s most-read articles: Analytical | Applied | Materials Science & Engineering | Multidisciplinary | Organic/Inorganic | Physical
ACS Biomaterials Science & Engineering
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Inhibition of Bacterial Adhesion on Nanotextured Stainless Steel 316L by Electrochemical Etching
Open Access through ACS AuthorChoice
ACS Biomater. Sci. Eng., 2018, 4 (1), pp 90–97
DOI: 10.1021/acsbiomaterials.7b00544
Early Career Board Announcement
ACS Biomater. Sci. Eng., 2018, 4 (10), pp 3450–3450
DOI: 10.1021/acsbiomaterials.8b01125
3D Printing of PDMS Improves Its Mechanical and Cell Adhesion Properties
ACS Biomater. Sci. Eng., 2018, 4 (2), pp 682–693
DOI: 10.1021/acsbiomaterials.7b00646
Isolation and Identification of Proteins Secreted by Cells Cultured within Synthetic Hydrogel-Based Matrices
Open Access through ACS Editors’ Choice
ACS Biomater. Sci. Eng., 2018, 4 (3), pp 836–845
DOI: 10.1021/acsbiomaterials.7b00647
In Vitro Modeling of Mechanics in Cancer Metastasis
This article is part of the Tissue Engineering and Biomaterials Approaches to Tumor Modeling special issue.
Open Access through ACS AuthorChoice
ACS Biomater. Sci. Eng., 2018, 4 (2), pp 294–301
DOI: 10.1021/acsbiomaterials.7b00041
ACS Catalysis
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Role of Interfaces in Two-Dimensional Photocatalyst for Water Splitting
ACS Catal., 2018, 8 (3), pp 2253–2276
DOI: 10.1021/acscatal.7b03437
Facile Ammonia Synthesis from Electrocatalytic N2 Reduction under Ambient Conditions on N-Doped Porous Carbon
ACS Catal., 2018, 8 (2), pp 1186–1191
DOI: 10.1021/acscatal.7b02165
Challenges and Prospects in Solar Water Splitting and CO2 Reduction with Inorganic and Hybrid Nanostructures
ACS Catal., 2018, 8 (4), pp 3602–3635
DOI: 10.1021/acscatal.8b00791
Oxidative Coupling Mechanisms: Current State of Understanding
Open Access through ACS Editors’ Choice
ACS Catal., 2018, 8 (2), pp 1161–1172
DOI: 10.1021/acscatal.7b02974
Mechanism of CO2 Reduction at Copper Surfaces: Pathways to C2 Products
ACS Catal., 2018, 8 (2), pp 1490–1499
DOI: 10.1021/acscatal.7b03477
ACS Chemical Biology
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CRISPR-Mediated Tagging of Endogenous Proteins with a Luminescent Peptide
Open Access through ACS AuthorChoice
ACS Chem. Biol., 2018, 13 (2), pp 467–474
DOI: 10.1021/acschembio.7b00549
Quantitative Live-Cell Kinetic Degradation and Mechanistic Profiling of PROTAC Mode of Action
Open Access through ACS AuthorChoice
ACS Chem. Biol., 2018, 13 (9), pp 2758–2770
DOI: 10.1021/acschembio.8b00692
Seven Year Itch: Pan-Assay Interference Compounds (PAINS) in 2017—Utility and Limitations
Open Access through ACS AuthorChoice
ACS Chem. Biol., 2018, 13 (1), pp 36–44
DOI: 10.1021/acschembio.7b00903
Site-Specific Incorporation of a Thioester Containing Amino Acid into Proteins
Open Access through ACS Editors’ Choice
ACS Chem. Biol., 2018, 13 (3), pp 578–581
DOI: 10.1021/acschembio.7b00998
CRISPRi and CRISPRa Screens in Mammalian Cells for Precision Biology and Medicine
This article is part of the Chemical Biology of CRISPR special issue.
ACS Chem. Biol., 2018, 13 (2), pp 406–416
DOI: 10.1021/acschembio.7b00657
ACS Chemical Neuroscience
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Drug–Target Kinetics in Drug Discovery
Open Access through ACS Editors’ Choice
ACS Chem. Neurosci., 2018, 9 (1), pp 29–39
DOI: 10.1021/acschemneuro.7b00185
Neuromicrobiology: How Microbes Influence the Brain
Open Access through ACS Editors’ Choice
ACS Chem. Neurosci., 2018, 9 (2), pp 141–150
DOI: 10.1021/acschemneuro.7b00373
Precision Medicine in Pediatric Neurooncology: A Review
This article is part of the Precision Medicine in Brain Cancer special issue.
Open Access through ACS Editors’ Choice
ACS Chem. Neurosci., 2018, 9 (1), pp 11–28
DOI: 10.1021/acschemneuro.7b00388
Global Neuroscience: China
ACS Chem. Neurosci., 2018, 9 (2), pp 138–139
DOI: 10.1021/acschemneuro.8b00048
Welcome to the DARK Side: DARK Classics in Chemical Neuroscience
This article is part of the DARK Classics in Chemical Neuroscience special issue.
ACS Chem. Neurosci., 2018, 9 (10), pp 2286–2286
DOI: 10.1021/acschemneuro.8b00528
ACS Infectious Diseases
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Developments in Glycopeptide Antibiotics
Open Access through ACS Editors’ Choice
ACS Infect. Dis., 2018, 4 (5), pp 715–735
DOI: 10.1021/acsinfecdis.7b00258
Fragment-Based Screening of a Natural Product Library against 62 Potential Malaria Drug Targets Employing Native Mass Spectrometry
Open Access through ACS Editors’ Choice
This article is part of the Drug Discovery for Global Health special issue.
ACS Infect. Dis., 2018, 4 (4), pp 431–444
DOI: 10.1021/acsinfecdis.7b00197
Targeting the Proteostasis Network for Mycobacterial Drug Discovery
This article is part of the Drug Discovery for Global Health special issue.
Open Access through ACS AuthorChoice
ACS Infect. Dis., 2018, 4 (4), pp 478–498
DOI: 10.1021/acsinfecdis.7b00231
The Human Microbiome
This article is part of the The Microbiome special issue.
ACS Infect. Dis., 2018, 4 (1), pp 1–2
DOI: 10.1021/acsinfecdis.7b00248
Total Syntheses of Bulgecins A, B, and C and Their Bactericidal Potentiation of the β-Lactam Antibiotics
Open Access through ACS Editors’ Choice
ACS Infect. Dis., 2018, 4 (6), pp 860–867
DOI: 10.1021/acsinfecdis.8b00105
ACS Medicinal Chemistry Letters
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Discovery of AG-120 (Ivosidenib): A First-in-Class Mutant IDH1 Inhibitor for the Treatment of IDH1 Mutant Cancers
Open Access through ACS AuthorChoice
ACS Med. Chem. Lett., 2018, 9 (4), pp 300–305
DOI: 10.1021/acsmedchemlett.7b00421
Investigating the Behavior of Published PAINS Alerts Using a Pharmaceutical Company Data Set
Open Access through ACS Editors’ Choice
ACS Med. Chem. Lett., 2018, 9 (8), pp 792–796
DOI: 10.1021/acsmedchemlett.8b00097
Discovery of Spiro Oxazolidinediones as Selective, Orally Bioavailable Inhibitors of p300/CBP Histone Acetyltransferases
Open Access through ACS Editors’ Choice
ACS Med. Chem. Lett., 2018, 9 (1), pp 28–33
DOI: 10.1021/acsmedchemlett.7b00395
Late-Stage Microsomal Oxidation Reduces Drug–Drug Interaction and Identifies Phosphodiesterase 2A Inhibitor PF-06815189
Open Access through ACS Editors’ Choice
ACS Med. Chem. Lett., 2018, 9 (2), pp 68–72
DOI: 10.1021/acsmedchemlett.7b00343
Strategy for Extending Half-life in Drug Design and Its Significance
This article is part of the Med Chem Tech: Driving Drug Development special issue.
ACS Med. Chem. Lett., 2018, 9 (6), pp 528–533
DOI: 10.1021/acsmedchemlett.8b00018
ACS Synthetic Biology
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Serine Integrases: Advancing Synthetic Biology
Open Access through ACS AuthorChoice
ACS Synth. Biol., 2018, 7 (2), pp 299–310
DOI: 10.1021/acssynbio.7b00308
Rational Design of Mini-Cas9 for Transcriptional Activation
ACS Synth. Biol., 2018, 7 (4), pp 978–985
DOI: 10.1021/acssynbio.7b00404
Biosynthesis of Orthogonal Molecules Using Ferredoxin and Ferredoxin-NADP+ Reductase Systems Enables Genetically Encoded PhyB Optogenetics
Open Access through ACS AuthorChoice
ACS Synth. Biol., 2018, 7 (2), pp 706–717
DOI: 10.1021/acssynbio.7b00413
Multiplexed CRISPR/Cas9 Genome Editing and Gene Regulation Using Csy4 in Saccharomyces cerevisiae
ACS Synth. Biol., 2018, 7 (1), pp 10–15
DOI: 10.1021/acssynbio.7b00259
Cameo: A Python Library for Computer Aided Metabolic Engineering and Optimization of Cell Factories
Open Access through ACS AuthorChoice
ACS Synth. Biol., 2018, 7 (4), pp 1163–1166
DOI: 10.1021/acssynbio.7b00423
Biochemistry
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Introducing the “Future of Biochemistry” Special Issue
Biochemistry, 2018, 57 (1), pp 1–8
DOI: 10.1021/acs.biochem.7b01259
New Opportunities Created by Single-Particle Cryo-EM: The Mapping of Conformational Space
Open Access through ACS Editors’ Choice
Biochemistry, 2018, 57 (6), pp 888–888
DOI: 10.1021/acs.biochem.8b00064
Extracellular Electron Transfer by the Gram-Positive Bacterium Enterococcus faecalis
Open Access through ACS AuthorChoice
Biochemistry, 2018, 57 (30), pp 4597–4603
DOI: 10.1021/acs.biochem.8b00600
Targeting the C481S Ibrutinib-Resistance Mutation in Bruton’s Tyrosine Kinase Using PROTAC-Mediated Degradation
Biochemistry, 2018, 57 (26), pp 3564–3575
DOI: 10.1021/acs.biochem.8b00391
Messenger RNA Structure Regulates Translation Initiation: A Mechanism Exploited from Bacteria to Humans
Biochemistry, 2018, 57 (26), pp 3537–3539
DOI: 10.1021/acs.biochem.8b00395
Bioconjugate Chemistry
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Practical Considerations, Challenges, and Limitations of Bioconjugation via Azide–Alkyne Cycloaddition
This article is part of the Bioconjugate Materials in Vaccines and Immunotherapies special issue.
Bioconjugate Chem., 2018, 29 (3), pp 686–701
DOI: 10.1021/acs.bioconjchem.7b00633
Imaging PD-L1 Expression with ImmunoPET
Open Access through ACS AuthorChoice
Bioconjugate Chem., 2018, 29 (1), pp 96–103
DOI: 10.1021/acs.bioconjchem.7b00631
Toll-like Receptor Agonist Conjugation: A Chemical Perspective
This article is part of the Bioconjugate Materials in Vaccines and Immunotherapies special issue.
Bioconjugate Chem., 2018, 29 (3), pp 587–603
DOI: 10.1021/acs.bioconjchem.7b00808
Silicon Rhodamine-Based Near-Infrared Fluorescent Probe for γ-Glutamyltransferase
Bioconjugate Chem., 2018, 29 (2), pp 241–244
DOI: 10.1021/acs.bioconjchem.7b00776
Positron Emission Tomography Imaging of Prostate Cancer with Ga-68-Labeled Gastrin-Releasing Peptide Receptor Agonist BBN7–14 and Antagonist RM26
Open Access through ACS Editors’ Choice
Bioconjugate Chem., 2018, 29 (2), pp 410–419
DOI: 10.1021/acs.bioconjchem.7b00726
Biomacromolecules
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Polymers at the Interface with Biology
Biomacromolecules, 2018, 19 (8), pp 3151–3162
DOI: 10.1021/acs.biomac.8b01029
Influence of Poly(styrene-co-maleic acid) Copolymer Structure on the Properties and Self-Assembly of SMALP Nanodiscs
Open Access through ACS AuthorChoice
Biomacromolecules, 2018, 19 (3), pp 761–772
DOI: 10.1021/acs.biomac.7b01539
Clinical Evidence for Use of a Noninvasive Biosensor for Tear Glucose as an Alternative to Painful Finger-Prick for Diabetes Management Utilizing a Biopolymer Coating
Open Access through ACS AuthorChoice
Biomacromolecules, 2018, 19 (11), pp 4504–4511
DOI: 10.1021/acs.biomac.8b01429
Mussel-Inspired Self-Healing Double-Cross-Linked Hydrogels by Controlled Combination of Metal Coordination and Covalent Cross-Linking
Open Access through ACS AuthorChoice
Biomacromolecules, 2018, 19 (5), pp 1402–1409
DOI: 10.1021/acs.biomac.7b01249
Injectable Hydrogel with Slow Degradability Composed of Gelatin and Hyaluronic Acid Cross-Linked by Schiff’s Base Formation
Biomacromolecules, 2018, 19 (2), pp 288–297
DOI: 10.1021/acs.biomac.7b01133
Journal of Agricultural and Food Chemistry
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Inhibition of Oral Pathogens Adhesion to Human Gingival Fibroblasts by Wine Polyphenols Alone and in Combination with an Oral Probiotic
Open Access through ACS Editors’ Choice
J. Agric. Food Chem., 2018, 66 (9), pp 2071–2082
DOI: 10.1021/acs.jafc.7b05466
Time-Resolved Gravimetric Method To Assess Degassing of Roasted Coffee
Open Access through ACS AuthorChoice
J. Agric. Food Chem., 2018, 66 (21), pp 5293–5300
DOI: 10.1021/acs.jafc.7b03310
Transcriptome Analysis of Hepatopancreas from the Cr (VI)-Stimulated Mantis Shrimp (Oratosquilla oratoria) by Illumina Paired-End Sequencing: Assembly, Annotation, and Expression Analysis
Open Access through ACS Editors’ Choice
J. Agric. Food Chem., 2018, 66 (11), pp 2598–2606
DOI: 10.1021/acs.jafc.7b05074
Yeast Metabolites of Glycated Amino Acids in Beer
Open Access through ACS Editors’ Choice
J. Agric. Food Chem., 2018, 66 (28), pp 7451–7460
DOI: 10.1021/acs.jafc.8b01329
Heterologous and High Production of Ergothioneine in Escherichia coli
Open Access through ACS Editors’ Choice
J. Agric. Food Chem., 2018, 66 (5), pp 1191–1196
DOI: 10.1021/acs.jafc.7b04924
Journal of Chemical Theory and Computation
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Where Does the Density Localize in the Solid State? Divergent Behavior for Hybrids and DFT+U
Open Access through ACS Editors’ Choice
J. Chem. Theory Comput., 2018, 14 (2), pp 670–683
DOI: 10.1021/acs.jctc.7b01061
Estimation of Drug-Target Residence Times by τ-Random Acceleration Molecular Dynamics Simulations
Open Access through ACS AuthorChoice
J. Chem. Theory Comput., 2018, 14 (7), pp 3859–3869
DOI: 10.1021/acs.jctc.8b00230
Force Field Parametrization of Metal Ions from Statistical Learning Techniques
Open Access through ACS AuthorChoice
J. Chem. Theory Comput., 2018, 14 (1), pp 255–273
DOI: 10.1021/acs.jctc.7b00779
Machine Learning Adaptive Basis Sets for Efficient Large Scale Density Functional Theory Simulation
Open Access through ACS Editors’ Choice
J. Chem. Theory Comput., 2018, 14 (8), pp 4168–4175
DOI: 10.1021/acs.jctc.8b00378
Avoiding False Positive Conclusions in Molecular Simulation: The Importance of Replicas
Open Access through ACS AuthorChoice
J. Chem. Theory Comput., 2018, 14 (12), pp 6127–6138
DOI: 10.1021/acs.jctc.8b00391
Journal of Medicinal Chemistry
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Protac-Induced Protein Degradation in Drug Discovery: Breaking the Rules or Just Making New Ones?
This article is part of the Inducing Protein Degradation as a Therapeutic Strategy special issue.
J. Med. Chem., 2018, 61 (2), pp 444–452
DOI: 10.1021/acs.jmedchem.7b01272
Discovery of GDC-0853: A Potent, Selective, and Noncovalent Bruton’s Tyrosine Kinase Inhibitor in Early Clinical Development
J. Med. Chem., 2018, 61 (6), pp 2227–2245
DOI: 10.1021/acs.jmedchem.7b01712
Discovery of a Small-Molecule Degrader of Bromodomain and Extra-Terminal (BET) Proteins with Picomolar Cellular Potencies and Capable of Achieving Tumor Regression
Open Access through ACS AuthorChoice
J. Med. Chem., 2018, 61 (2), pp 462–481
DOI: 10.1021/acs.jmedchem.6b01816
Recent Advances in Structure-Based Drug Design Targeting Class A G Protein-Coupled Receptors Utilizing Crystal Structures and Computational Simulations
Open Access through ACS AuthorChoice
J. Med. Chem., 2018, 61 (1), pp 1–46
DOI: 10.1021/acs.jmedchem.6b01453
Inducing Protein Degradation as a Therapeutic Strategy
This article is part of the Inducing Protein Degradation as a Therapeutic Strategy special issue.
J. Med. Chem., 2018, 61 (2), pp 403–404
DOI: 10.1021/acs.jmedchem.7b01333
Journal of Natural Products
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Bioactivity-Based Molecular Networking for the Discovery of Drug Leads in Natural Product Bioassay-Guided Fractionation
Open Access through ACS Editors’ Choice
J. Nat. Prod., 2018, 81 (4), pp 758–767
DOI: 10.1021/acs.jnatprod.7b00737
Quest for Efficacious Next-Generation Taxoid Anticancer Agents and Their Tumor-Targeted Delivery
This article is part of the Special Issue in Honor of Susan Horwitz special issue.
Open Access through ACS Editors’ Choice
J. Nat. Prod., 2018, 81 (3), pp 703–721
DOI: 10.1021/acs.jnatprod.7b01012
Jizanpeptins, Cyanobacterial Protease Inhibitors from a Symploca sp. Cyanobacterium Collected in the Red Sea
Open Access through ACS Editors’ Choice
J. Nat. Prod., 2018, 81 (6), pp 1417–1425
DOI: 10.1021/acs.jnatprod.8b00117
Natural Deep Eutectic Solvents: Properties, Applications, and Perspectives
This article is part of the Special Issue in Honor of Susan Horwitz special issue.
J. Nat. Prod., 2018, 81 (3), pp 679–690
DOI: 10.1021/acs.jnatprod.7b00945
Keikipukalides, Furanocembrane Diterpenes from the Antarctic Deep Sea Octocoral Plumarella delicatissima
Open Access through ACS AuthorChoice
J. Nat. Prod., 2018, 81 (1), pp 117–123
DOI: 10.1021/acs.jnatprod.7b00732
The Journal of Physical Chemistry B
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The Bend+Libration Combination Band Is an Intrinsic, Collective, and Strongly Solute-Dependent Reporter on the Hydrogen Bonding Network of Liquid Water
Open Access through ACS Editors’ Choice
J. Phys. Chem. B, 2018, 122 (9), pp 2587–2599
DOI: 10.1021/acs.jpcb.7b09641
Virtual Issue on Physical Chemistry in South Korea
J. Phys. Chem. B, 2018, 122 (35), pp 8315–8316
DOI: 10.1021/acs.jpcb.8b07245
Dynamics of Long-Distance Hydrogen-Bond Networks in Photosystem II
Open Access through ACS Editors’ Choice
J. Phys. Chem. B, 2018, 122 (17), pp 4625–4641
DOI: 10.1021/acs.jpcb.8b00649
Exploring GPCR–Lipid Interactions by Molecular Dynamics Simulations: Excitements, Challenges, and the Way Forward
Open Access through ACS Editors’ Choice
J. Phys. Chem. B, 2018, 122 (22), pp 5727–5737
DOI: 10.1021/acs.jpcb.8b01657
Structure from Dynamics: Vibrational Dynamics of Interfacial Water as a Probe of Aqueous Heterogeneity
Open Access through ACS Editors’ Choice
J. Phys. Chem. B, 2018, 122 (14), pp 3667–3679
DOI: 10.1021/acs.jpcb.7b10574
The Journal of Physical Chemistry Letters
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Accelerating Chemical Discovery with Machine Learning: Simulated Evolution of Spin Crossover Complexes with an Artificial Neural Network
Open Access through ACS AuthorChoice
J. Phys. Chem. Lett., 2018, 9 (5), pp 1064–1071
DOI: 10.1021/acs.jpclett.8b00170
Zero-Dimensional Cesium Lead Halides: History, Properties, and Challenges
Open Access through ACS Editors’ Choice
J. Phys. Chem. Lett., 2018, 9 (9), pp 2326–2337
DOI: 10.1021/acs.jpclett.8b00572
Atomic Layer Etching: Rethinking the Art of Etch
Open Access through ACS AuthorChoice
J. Phys. Chem. Lett., 2018, 9 (16), pp 4814–4821
DOI: 10.1021/acs.jpclett.8b00997
Molecular Insight into the Slipperiness of Ice
Open Access through ACS AuthorChoice
J. Phys. Chem. Lett., 2018, 9 (11), pp 2838–2842
DOI: 10.1021/acs.jpclett.8b01188
Lead-Free Perovskite Nanocrystals for Light-Emitting Devices
J. Phys. Chem. Lett., 2018, 9 (7), pp 1573–1583
DOI: 10.1021/acs.jpclett.8b00301
Journal of Proteome Research
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Performance Evaluation of the Q Exactive HF-X for Shotgun Proteomics
J. Proteome Res., 2018, 17 (1), pp 727–738
DOI: 10.1021/acs.jproteome.7b00602
Deep Learning Accurately Predicts Estrogen Receptor Status in Breast Cancer Metabolomics Data
Open Access through ACS AuthorChoice
J. Proteome Res., 2018, 17 (1), pp 337–347
DOI: 10.1021/acs.jproteome.7b00595
Polylysine is a Proteostasis Network-Engaging Structural Determinant
Open Access through ACS AuthorChoice
J. Proteome Res., 2018, 17 (5), pp 1967–1977
DOI: 10.1021/acs.jproteome.8b00108
Extending the Compatibility of the SP3 Paramagnetic Bead Processing Approach for Proteomics
J. Proteome Res., 2018, 17 (4), pp 1730–1740
DOI: 10.1021/acs.jproteome.7b00913
Comparison of Internal Standard Approaches for SRM Analysis of Alpha-Synuclein in Cerebrospinal Fluid
Open Access through ACS Editors’ Choice
J. Proteome Res., 2018, 17 (1), pp 516–523
DOI: 10.1021/acs.jproteome.7b00660
Molecular Pharmaceutics
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Oral Administration and Detection of a Near-Infrared Molecular Imaging Agent in an Orthotopic Mouse Model for Breast Cancer Screening
Open Access through ACS Editors’ Choice
Mol. Pharmaceutics, 2018, 15 (5), pp 1746–1754
DOI: 10.1021/acs.molpharmaceut.7b00994
Artificial Intelligence for Drug Discovery, Biomarker Development, and Generation of Novel Chemistry
This article is part of the Deep Learning for Drug Discovery and Biomarker Development special issue.
Mol. Pharmaceutics, 2018, 15 (10), pp 4311–4313
DOI: 10.1021/acs.molpharmaceut.8b00930
Entangled Conditional Adversarial Autoencoder for de Novo Drug Discovery
Open Access through ACS AuthorChoice
Mol. Pharmaceutics, 2018, 15 (10), pp 4398–4405
DOI: 10.1021/acs.molpharmaceut.8b00839
Adversarial Threshold Neural Computer for Molecular de Novo Design
This article is part of the Deep Learning for Drug Discovery and Biomarker Development special issue.
Open Access through ACS AuthorChoice
Mol. Pharmaceutics, 2018, 15 (10), pp 4386–4397
DOI: 10.1021/acs.molpharmaceut.7b01137
3D Molecular Representations Based on the Wave Transform for Convolutional Neural Networks
This article is part of the Deep Learning for Drug Discovery and Biomarker Development special issue.
Open Access through ACS AuthorChoice
Mol. Pharmaceutics, 2018, 15 (10), pp 4378–4385
DOI: 10.1021/acs.molpharmaceut.7b01134