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Most-Read Articles of 2018: Organic/Inorganic Chemistry

There are lots of different ways to look at the reach of an article. You can look at citations, Altmetric Attention Scores, awards, and more. One way to consider the influence of an article is just by looking at how many people chose to read it. To that end, we’ve compiled lists of the five most-read chemistry articles that appeared in each ACS Publications journal in 2018, including research, reviews, perspectives, and editorial pieces. These lists were not chosen by the journal’s editors and should not be taken as a “best of” list, but as another perspective on where the chemistry community allocated their attention over the past year.

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Read more of 2018’s most-read articles: Analytical | Applied | Biological | Materials Science & Engineering | Multidisciplinary | Physical


ACS Catalysis

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Role of Interfaces in Two-Dimensional Photocatalyst for Water Splitting
ACS Catal., 2018, 8 (3), pp 2253–2276
DOI: 10.1021/acscatal.7b03437

Facile Ammonia Synthesis from Electrocatalytic N2 Reduction under Ambient Conditions on N-Doped Porous Carbon
ACS Catal., 2018, 8 (2), pp 1186–1191
DOI: 10.1021/acscatal.7b02165

Challenges and Prospects in Solar Water Splitting and CO2 Reduction with Inorganic and Hybrid Nanostructures
ACS Catal., 2018, 8 (4), pp 3602–3635
DOI: 10.1021/acscatal.8b00791

Oxidative Coupling Mechanisms: Current State of Understanding
Open Access through ACS Editors’ Choice
ACS Catal., 2018, 8 (2), pp 1161–1172
DOI: 10.1021/acscatal.7b02974

Mechanism of CO2 Reduction at Copper Surfaces: Pathways to C2 Products
ACS Catal., 2018, 8 (2), pp 1490–1499
DOI: 10.1021/acscatal.7b03477


ACS Combinatorial Science

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Synthesis of Highly Substituted Imidazole Uracil Containing Molecules via Ugi-4CR and Passerini-3CR
Open Access through ACS AuthorChoice
ACS Comb. Sci., 2018, 20 (4), pp 192–196
DOI: 10.1021/acscombsci.7b00145

Solid-Phase Synthesis of β-Amino Ketones Via DNA-Compatible Organocatalytic Mannich Reactions
ACS Comb. Sci., 2018, 20 (2), pp 55–60
DOI: 10.1021/acscombsci.7b00151

Detection of Circulating Tumor Cells Using Microfluidics
ACS Comb. Sci., 2018, 20 (3), pp 107–126
DOI: 10.1021/acscombsci.7b00146

DNA-Compatible Solid-Phase Combinatorial Synthesis of β-Cyanoacrylamides and Related Electrophiles
ACS Comb. Sci., 2018, 20 (2), pp 61–69
DOI: 10.1021/acscombsci.7b00169

Comparison of Cell Permeability of Cyclic Peptoids and Linear Peptoids
ACS Comb. Sci., 2018, 20 (4), pp 237–242
DOI: 10.1021/acscombsci.7b00194


ACS Medicinal Chemistry Letters

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Discovery of AG-120 (Ivosidenib): A First-in-Class Mutant IDH1 Inhibitor for the Treatment of IDH1 Mutant Cancers
Open Access through ACS AuthorChoice
ACS Med. Chem. Lett., 2018, 9 (4), pp 300–305
DOI: 10.1021/acsmedchemlett.7b00421

Investigating the Behavior of Published PAINS Alerts Using a Pharmaceutical Company Data Set
Open Access through ACS Editors’ Choice
ACS Med. Chem. Lett., 2018, 9 (8), pp 792–796
DOI: 10.1021/acsmedchemlett.8b00097

Discovery of Spiro Oxazolidinediones as Selective, Orally Bioavailable Inhibitors of p300/CBP Histone Acetyltransferases
Open Access through ACS Editors’ Choice
ACS Med. Chem. Lett., 2018, 9 (1), pp 28–33
DOI: 10.1021/acsmedchemlett.7b00395

Late-Stage Microsomal Oxidation Reduces Drug–Drug Interaction and Identifies Phosphodiesterase 2A Inhibitor PF-06815189
Open Access through ACS Editors’ Choice
ACS Med. Chem. Lett., 2018, 9 (2), pp 68–72
DOI: 10.1021/acsmedchemlett.7b00343

Strategy for Extending Half-life in Drug Design and Its Significance
This article is part of the Med Chem Tech: Driving Drug Development special issue.
ACS Med. Chem. Lett., 2018, 9 (6), pp 528–533
DOI: 10.1021/acsmedchemlett.8b00018


Bioconjugate Chemistry

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Practical Considerations, Challenges, and Limitations of Bioconjugation via Azide–Alkyne Cycloaddition
This article is part of the Bioconjugate Materials in Vaccines and Immunotherapies special issue.
Bioconjugate Chem., 2018, 29 (3), pp 686–701
DOI: 10.1021/acs.bioconjchem.7b00633

Imaging PD-L1 Expression with ImmunoPET
Open Access through ACS AuthorChoice
Bioconjugate Chem., 2018, 29 (1), pp 96–103
DOI: 10.1021/acs.bioconjchem.7b00631

Toll-like Receptor Agonist Conjugation: A Chemical Perspective
This article is part of the Bioconjugate Materials in Vaccines and Immunotherapies special issue.
Bioconjugate Chem., 2018, 29 (3), pp 587–603
DOI: 10.1021/acs.bioconjchem.7b00808

Silicon Rhodamine-Based Near-Infrared Fluorescent Probe for γ-Glutamyltransferase
Bioconjugate Chem., 2018, 29 (2), pp 241–244
DOI: 10.1021/acs.bioconjchem.7b00776

Positron Emission Tomography Imaging of Prostate Cancer with Ga-68-Labeled Gastrin-Releasing Peptide Receptor Agonist BBN7–14 and Antagonist RM26
Open Access through ACS Editors’ Choice
Bioconjugate Chem., 2018, 29 (2), pp 410–419
DOI: 10.1021/acs.bioconjchem.7b00726


Inorganic Chemistry

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The Five Stages of Rejection
Inorg. Chem., 2018, 57 (9), pp 4789–4790
DOI: 10.1021/acs.inorgchem.8b00900

Catalytic Performance of a Dicopper–Oxo Complex for Methane Hydroxylation
Open Access through ACS Editors’ Choice
Inorg. Chem., 2018, 57 (1), pp 8–11
DOI: 10.1021/acs.inorgchem.7b02563

Fluorescent Metal–Organic Framework (MOF) as a Highly Sensitive and Quickly Responsive Chemical Sensor for the Detection of Antibiotics in Simulated Wastewater
Inorg. Chem., 2018, 57 (3), pp 1060–1065
DOI: 10.1021/acs.inorgchem.7b02471

Encapsulation of CH3NH3PbBr3 Perovskite Quantum Dots in MOF-5 Microcrystals as a Stable Platform for Temperature and Aqueous Heavy Metal Ion Detection
Inorg. Chem., 2018, 57 (8), pp 4613–4619
DOI: 10.1021/acs.inorgchem.8b00355

Selective Recognition of Hg2+ ion in Water by a Functionalized Metal–Organic Framework (MOF) Based Chemodosimeter
Inorg. Chem., 2018, 57 (5), pp 2360–2364
DOI: 10.1021/acs.inorgchem.7b02426


Journal of Medicinal Chemistry

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Protac-Induced Protein Degradation in Drug Discovery: Breaking the Rules or Just Making New Ones?
This article is part of the Inducing Protein Degradation as a Therapeutic Strategy special issue.
J. Med. Chem., 2018, 61 (2), pp 444–452
DOI: 10.1021/acs.jmedchem.7b01272

Discovery of GDC-0853: A Potent, Selective, and Noncovalent Bruton’s Tyrosine Kinase Inhibitor in Early Clinical Development
J. Med. Chem., 2018, 61 (6), pp 2227–2245
DOI: 10.1021/acs.jmedchem.7b01712

Discovery of a Small-Molecule Degrader of Bromodomain and Extra-Terminal (BET) Proteins with Picomolar Cellular Potencies and Capable of Achieving Tumor Regression
Open Access through ACS AuthorChoice
J. Med. Chem., 2018, 61 (2), pp 462–481
DOI: 10.1021/acs.jmedchem.6b01816

Recent Advances in Structure-Based Drug Design Targeting Class A G Protein-Coupled Receptors Utilizing Crystal Structures and Computational Simulations
Open Access through ACS AuthorChoice
J. Med. Chem., 2018, 61 (1), pp 1–46
DOI: 10.1021/acs.jmedchem.6b01453

Inducing Protein Degradation as a Therapeutic Strategy
This article is part of the Inducing Protein Degradation as a Therapeutic Strategy special issue.
J. Med. Chem., 2018, 61 (2), pp 403–404
DOI: 10.1021/acs.jmedchem.7b01333


Journal of Natural Products

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Bioactivity-Based Molecular Networking for the Discovery of Drug Leads in Natural Product Bioassay-Guided Fractionation
Open Access through ACS Editors’ Choice
J. Nat. Prod., 2018, 81 (4), pp 758–767
DOI: 10.1021/acs.jnatprod.7b00737

Quest for Efficacious Next-Generation Taxoid Anticancer Agents and Their Tumor-Targeted Delivery
This article is part of the Special Issue in Honor of Susan Horwitz special issue.
Open Access through ACS Editors’ Choice
J. Nat. Prod., 2018, 81 (3), pp 703–721
DOI: 10.1021/acs.jnatprod.7b01012

Jizanpeptins, Cyanobacterial Protease Inhibitors from a Symploca sp. Cyanobacterium Collected in the Red Sea
Open Access through ACS Editors’ Choice
J. Nat. Prod., 2018, 81 (6), pp 1417–1425
DOI: 10.1021/acs.jnatprod.8b00117

Natural Deep Eutectic Solvents: Properties, Applications, and Perspectives
This article is part of the Special Issue in Honor of Susan Horwitz special issue.
J. Nat. Prod., 2018, 81 (3), pp 679–690
DOI: 10.1021/acs.jnatprod.7b00945

Keikipukalides, Furanocembrane Diterpenes from the Antarctic Deep Sea Octocoral Plumarella delicatissima
Open Access through ACS AuthorChoice
J. Nat. Prod., 2018, 81 (1), pp 117–123
DOI: 10.1021/acs.jnatprod.7b00732


The Journal of Organic Chemistry

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Regioselective Halogenation of Arenes and Heterocycles in Hexafluoroisopropanol
J. Org. Chem., 2018, 83 (2), pp 930–938
DOI: 10.1021/acs.joc.7b02920

Synthesis and Explosion Hazards of 4-Azido-l-phenylalanine
J. Org. Chem., 2018, 83 (8), pp 4525–4536
DOI: 10.1021/acs.joc.8b00270

Chemistry Takes a Bath: Reactions in Aqueous Media
This article is part of the Organic and Biocompatible Transformations in Aqueous Media special issue.
J. Org. Chem., 2018, 83 (14), pp 7319–7322
DOI: 10.1021/acs.joc.8b01412

Evolution of a Strategy for the Enantioselective Total Synthesis of (+)-Psiguadial B
J. Org. Chem., 2018, 83 (11), pp 6066–6085
DOI: 10.1021/acs.joc.8b00728

Cyanthiwigin Natural Product Core as a Complex Molecular Scaffold for Comparative Late-Stage C–H Functionalization Studies
Open Access through ACS Editors’ Choice
J. Org. Chem., 2018, 83 (6), pp 3023–3033
DOI: 10.1021/acs.joc.7b03291


Molecular Pharmaceutics

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Oral Administration and Detection of a Near-Infrared Molecular Imaging Agent in an Orthotopic Mouse Model for Breast Cancer Screening
Open Access through ACS Editors’ Choice
Mol. Pharmaceutics, 2018, 15 (5), pp 1746–1754
DOI: 10.1021/acs.molpharmaceut.7b00994

Artificial Intelligence for Drug Discovery, Biomarker Development, and Generation of Novel Chemistry
This article is part of the Deep Learning for Drug Discovery and Biomarker Development special issue.
Mol. Pharmaceutics, 2018, 15 (10), pp 4311–4313
DOI: 10.1021/acs.molpharmaceut.8b00930

Entangled Conditional Adversarial Autoencoder for de Novo Drug Discovery
Open Access through ACS AuthorChoice
Mol. Pharmaceutics, 2018, 15 (10), pp 4398–4405
DOI: 10.1021/acs.molpharmaceut.8b00839

Adversarial Threshold Neural Computer for Molecular de Novo Design
This article is part of the Deep Learning for Drug Discovery and Biomarker Development special issue.
Open Access through ACS AuthorChoice
Mol. Pharmaceutics, 2018, 15 (10), pp 4386–4397
DOI: 10.1021/acs.molpharmaceut.7b01137

3D Molecular Representations Based on the Wave Transform for Convolutional Neural Networks
This article is part of the Deep Learning for Drug Discovery and Biomarker Development special issue.
Open Access through ACS AuthorChoice
Mol. Pharmaceutics, 2018, 15 (10), pp 4378–4385
DOI: 10.1021/acs.molpharmaceut.7b01134


Organic Letters

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A Practical and Chemoselective Ammonia-Free Birch Reduction
Org. Lett., 2018, 20 (12), pp 3439–3442
DOI: 10.1021/acs.orglett.8b00891

Palladium-Catalyzed C–O Cross-Coupling of Primary Alcohols
Org. Lett., 2018, 20 (6), pp 1580–1583
DOI: 10.1021/acs.orglett.8b00325

Tetramethyl Orthosilicate (TMOS) as a Reagent for Direct Amidation of Carboxylic Acids
Open Access through ACS AuthorChoice
Org. Lett., 2018, 20 (4), pp 950–953
DOI: 10.1021/acs.orglett.7b03841

Total Synthesis of (±)–Exotine B
Open Access through ACS Editors’ Choice
Org. Lett., 2018, 20 (14), pp 4358–4361
DOI: 10.1021/acs.orglett.8b01817

Ni-Catalyzed Electrochemical Decarboxylative C–C Couplings in Batch and Continuous Flow
Open Access through ACS AuthorChoice
Org. Lett., 2018, 20 (5), pp 1338–1341
DOI: 10.1021/acs.orglett.8b00070


Organic Process Research & Development

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Applications of Flow Chemistry in Drug Development: Highlights of Recent Patent Literature
Org. Process Res. Dev., 2018, 22 (1), pp 13–20
DOI: 10.1021/acs.oprd.7b00363

Recent Developments in the Reduction of Aromatic and Aliphatic Nitro Compounds to Amines
Org. Process Res. Dev., 2018, 22 (4), pp 430–445
DOI: 10.1021/acs.oprd.6b00205

Some Items of Interest to Process R&D Chemists and Engineers
Org. Process Res. Dev., 2018, 22 (1), pp 1–12
DOI: 10.1021/acs.oprd.7b00390

Some Items of Interest to Process R&D Chemists and Engineers
Org. Process Res. Dev., 2018, 22 (3), pp 257–266
DOI: 10.1021/acs.oprd.8b00061

Synthetic Strategies toward SGLT2 Inhibitors
Open Access through ACS AuthorChoice
Org. Process Res. Dev., 2018, 22 (4), pp 467–488
DOI: 10.1021/acs.oprd.8b00017


Organometallics

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A Universally Applicable Methodology for the Gram-Scale Synthesis of Primary, Secondary, and Tertiary Phosphines
Organometallics, 2018, 37 (2), pp 182–190
DOI: 10.1021/acs.organomet.7b00684

Dos and Don’ts: Thoughts on How To Respond to Reviewer Comments
Organometallics, 2018, 37 (16), pp 2655–2655
DOI: 10.1021/acs.organomet.8b00515

Quantifying Structural Effects of Amino Acid Ligands in Pd(II)-Catalyzed Enantioselective C–H Functionalization Reactions
Organometallics, 2018, 37 (2), pp 203–210
DOI: 10.1021/acs.organomet.7b00751

Pitfalls in Computational Modeling of Chemical Reactions and How To Avoid Them
Organometallics, 2018, 37 (19), pp 3228–3239
DOI: 10.1021/acs.organomet.8b00456

Selective Isomerization of Terminal Alkenes to (Z)-2-Alkenes Catalyzed by an Air-Stable Molybdenum(0) Complex
Organometallics, 2018, 37 (3), pp 482–490
DOI: 10.1021/acs.organomet.7b00914

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