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Discover the Most-Read Organic/Inorganic Chemistry Articles of January 2019

There are lots of different ways to look at the reach of an article. You can look at citations, Altmetric Attention Scores, awards, and more. One way to consider the influence of an article is just by looking at how many people chose to read it. To that end, we’ve compiled lists of the five most-read chemistry articles that appeared in each ACS Publications journal in January 2019, including research, reviews, perspectives, and editorial pieces. These lists were not chosen by the journal’s editors and should not be taken as a “best of” list, but as another perspective on where the chemistry community allocated their attention.

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Read more of January’s most-read articles: Analytical | Applied | Biological | Materials Science & Engineering | Multidisciplinary | Organic/Inorganic | Physical


ACS Catalysis

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Phenol-Directed C–H Functionalization
ACS Catal., 2019, 9 (1), pp 521–555
DOI: 10.1021/acscatal.8b04098

Visible-Light-Mediated Deaminative Three-Component Dicarbofunctionalization of Styrenes with Benzylic Radicals
ACS Catal., 2019, 9 (1), pp 236–241
DOI: 10.1021/acscatal.8b04191

Rational Design of Fe–N/C Hybrid for Enhanced Nitrogen Reduction Electrocatalysis under Ambient Conditions in Aqueous Solution
ACS Catal., 2019, 9 (1), pp 336–344
DOI: 10.1021/acscatal.8b03802

Dehydrogenative Cross-Coupling of Primary Alcohols To Form Cross-Esters Catalyzed by a Manganese Pincer Complex
ACS Catal., 2019, 9 (1), pp 479–484
DOI: 10.1021/acscatal.8b04585

Photocatalysis with Reduced TiO2: From Black TiO2 to Cocatalyst-Free Hydrogen Production
Open Access Through ACS AuthorChoice
ACS Catal., 2019, 9 (1), pp 345–364
DOI: 10.1021/acscatal.8b04068


ACS Combinatorial Science

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Combinatorial Peptide Microarray Synthesis Based on Microfluidic Impact Printing
Open Access Through ACS Editors’ Choice
ACS Comb. Sci., 2019, 21 (1), pp 6–10
DOI: 10.1021/acscombsci.8b00125

Synthesis of D-Ring Annulated Pyridosteroids from β-Formyl Enamides and Their Biological Evaluations
ACS Comb. Sci., 2019, 21 (1), pp 11–27
DOI: 10.1021/acscombsci.8b00140

Multicomponent Approach to a Library of N-Substituted γ-Lactams
ACS Comb. Sci., 2019, 21 (1), pp 28–34
DOI: 10.1021/acscombsci.8b00147

Traceless Solid-Phase Synthesis of 1′H-Spiro[Pyrrolidine-3,2′-quinazolin]-2-ones and 1′H-Spiro[Piperidine-3,2′-quinazolin]-2-ones via Lactamization of 1,2-Dihydroquinazoline-2-carboxylates
ACS Comb. Sci., 2019, 21 (1), pp 1–5
DOI: 10.1021/acscombsci.8b00145


ACS Medicinal Chemistry Letters

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The ProTide Prodrug Technology: Where Next?
ACS Med. Chem. Lett., 2019, 10 (1), pp 2–5
DOI: 10.1021/acsmedchemlett.8b00586

Discovery of a Novel cGAMP Competitive Ligand of the Inactive Form of STING
ACS Med. Chem. Lett., 2019, 10 (1), pp 92–97
DOI: 10.1021/acsmedchemlett.8b00466

Discovery of a GPR40 Superagonist: The Impact of Aryl Propionic Acid α-Fluorination
ACS Med. Chem. Lett., 2019, 10 (1), pp 16–21
DOI: 10.1021/acsmedchemlett.8b00444

ASK1: A Therapeutic Target for the Treatment of Multiple Diseases
ACS Med. Chem. Lett., 2019, 10 (1), pp 12–13
DOI: 10.1021/acsmedchemlett.8b00621

Inhibitors of G12C Mutant Ras Proteins for the Treatment of Cancers
ACS Med. Chem. Lett., 2019, 10 (1), pp 10–11
DOI: 10.1021/acsmedchemlett.8b00576


Bioconjugate Chemistry

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A New Infrared Probe Targeting Mitochondria via Regulation of Molecular Hydrophobicity
Open Access Through ACS Editors’ Choice
Bioconjugate Chem., 2019, 30 (1), pp 210–217
DOI: 10.1021/acs.bioconjchem.8b00845

Development, Optimization, and Structural Characterization of an Efficient Peptide-Based Photoaffinity Cross-Linking Reaction for Generation of Homogeneous Conjugates from Wild-Type Antibodies
Bioconjugate Chem., 2019, 30 (1), pp 148–160
DOI: 10.1021/acs.bioconjchem.8b00809

Comparative Antigenicity of Thiourea and Adipic Amide Linked Neoglycoconjugates Containing Modified Oligomannose Epitopes for the Carbohydrate-Specific anti-HIV Antibody 2G12
Open Access Through ACS AuthorChoice
Bioconjugate Chem., 2019, 30 (1), pp 70–82
DOI: 10.1021/acs.bioconjchem.8b00731

BODIPY with Tuned Amphiphilicity as a Fluorogenic Plasma Membrane Probe
Bioconjugate Chem., 2019, 30 (1), pp 192–199
DOI: 10.1021/acs.bioconjchem.8b00828

Glutathione Triggered Cascade Degradation of an Amphiphilic Poly(disulfide)–Drug Conjugate and Targeted Release
Bioconjugate Chem., 2019, 30 (1), pp 101–110
DOI: 10.1021/acs.bioconjchem.8b00781


Inorganic Chemistry

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Bonding in Chemistry: Surprising Results from an Ordinary Glovebox
Inorg. Chem., 2019, 58 (2), pp 977–978
DOI: 10.1021/acs.inorgchem.9b00015

Sustainable Inorganic Chemistry: Metal Separations for Recycling
Inorg. Chem., 2019, 58 (2), pp 979–990
DOI: 10.1021/acs.inorgchem.8b01871

Emerging Investigators in Solid-State Inorganic Chemistry
Inorg. Chem., 2019, 58 (1), pp 4–7
DOI: 10.1021/acs.inorgchem.8b03382

Keeping Those Resolutions
Inorg. Chem., 2019, 58 (1), pp 1–3
DOI: 10.1021/acs.inorgchem.8b03444

Strategies Employing Transition Metal Complexes To Modulate Amyloid-β Aggregation
Inorg. Chem., 2019, 58 (1), pp 8–17
DOI: 10.1021/acs.inorgchem.8b02813


Journal of Medicinal Chemistry

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Allosteric Modulators of Drug Targets
This article is part of the Allosteric Modulators special issue.
J. Med. Chem., 2019, 62 (1), pp 1–2
DOI: 10.1021/acs.jmedchem.8b01902

Iterative Design and Optimization of Initially Inactive Proteolysis Targeting Chimeras (PROTACs) Identify VZ185 as a Potent, Fast, and Selective von Hippel–Lindau (VHL) Based Dual Degrader Probe of BRD9 and BRD7
Open Access Through ACS AuthorChoice
J. Med. Chem., 2019, 62 (2), pp 699–726
DOI: 10.1021/acs.jmedchem.8b01413

Targeted Degradation of MDM2 as a New Approach to Improve the Efficacy of MDM2-p53 Inhibitors
J. Med. Chem., 2019, 62 (2), pp 445–447
DOI: 10.1021/acs.jmedchem.8b01945

Novel 1,3,4-Selenadiazole-Containing Kidney-Type Glutaminase Inhibitors Showed Improved Cellular Uptake and Antitumor Activity
J. Med. Chem., 2019, 62 (2), pp 589–603
DOI: 10.1021/acs.jmedchem.8b01198

Polypharmacology by Design: A Medicinal Chemist’s Perspective on Multitargeting Compounds
J. Med. Chem., 2019, 62 (2), pp 420–444
DOI: 10.1021/acs.jmedchem.8b00760


The Journal of Natural Products

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3,4-seco-Norclerodane Diterpenoids from the Roots of Polyalthia laui
J. Nat. Prod., 2019, 82 (1), pp 27–34
DOI: 10.1021/acs.jnatprod.8b00243

Secondary Metabolites from the Fungus Dictyosporium sp. and Their MALT1 Inhibitory Activities
J. Nat. Prod., 2019, 82 (1), pp 154–162
DOI: 10.1021/acs.jnatprod.8b00871

Access to Natural Valparanes and Daucanes: Enantioselective Synthesis of (−)-Valpara-2,15-diene and (+)-Isodaucene
J. Nat. Prod., 2019, 82 (1), pp 9–15
DOI: 10.1021/acs.jnatprod.8b00129

Chemical and Metagenomic Studies of the Lethal Black Band Disease of Corals Reveal Two Broadly Distributed, Redox-Sensitive Mixed Polyketide/Peptide Macrocycles
Open Access Through ACS Editors’ Choice
J. Nat. Prod., 2019, 82 (1), pp 111–121
DOI: 10.1021/acs.jnatprod.8b00804

Divirensols: Sesquiterpene Dimers from the Australian Termite Nest-Derived Fungus Trichoderma virens CMB-TN16
J. Nat. Prod., 2019, 82 (1), pp 87–95
DOI: 10.1021/acs.jnatprod.8b00746


The Journal of Organic Chemistry

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Total Synthesis of the Antidiabetic (Type 2) Lipid Mediator Protectin DX/PDX
J. Org. Chem., 2019, 84 (2), pp 495–505
DOI: 10.1021/acs.joc.8b01973

Regioselective Manipulation of GlcNAc Provides Allosamine, Lividosamine, and Related Compounds
Open Access Through ACS AuthorChoice
J. Org. Chem., 2019, 84 (2), pp 516–525
DOI: 10.1021/acs.joc.8b01949

Amination of Aromatic Halides and Exploration of the Reactivity Sequence of Aromatic Halides
J. Org. Chem., 2019, 84 (1), pp 181–190
DOI: 10.1021/acs.joc.8b02588

Isoindolinone Synthesis: Selective Dioxane-Mediated Aerobic Oxidation of Isoindolines
J. Org. Chem., 2019, 84 (2), pp 1025–1034
DOI: 10.1021/acs.joc.8b01920

Asymmetric Catalytic Halofunctionalization of α,β-Unsaturated Carbonyl Compounds
J. Org. Chem., 2019, 84 (1), pp 1–13
DOI: 10.1021/acs.joc.8b01951


Molecular Pharmaceutics

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Gold Nanoparticles in Cancer Treatment
Mol. Pharmaceutics, 2019, 16 (1), pp 1–23
DOI: 10.1021/acs.molpharmaceut.8b00810

Exosome as a Novel Shuttle for Delivery of Therapeutics across Biological Barriers
Mol. Pharmaceutics, 2019, 16 (1), pp 24–40
DOI: 10.1021/acs.molpharmaceut.8b00901

Antibody-Assisted Delivery of a Peptide–Drug Conjugate for Targeted Cancer Therapy
Mol. Pharmaceutics, 2019, 16 (1), pp 165–172
DOI: 10.1021/acs.molpharmaceut.8b00924

Enhancing Anti-PD-1/PD-L1 Immune Checkpoint Inhibitory Cancer Therapy by CD276-Targeted Photodynamic Ablation of Tumor Cells and Tumor Vasculature
Mol. Pharmaceutics, 2019, 16 (1), pp 339–348
DOI: 10.1021/acs.molpharmaceut.8b00997

Insight into Amorphous Solid Dispersion Performance by Coupled Dissolution and Membrane Mass Transfer Measurements
Mol. Pharmaceutics, 2019, 16 (1), pp 448–461
DOI: 10.1021/acs.molpharmaceut.8b01117


Organic Letters

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Organic Letters 2.0: A New Beginning
Org. Lett., 2019, 21 (1), pp 1–4
DOI: 10.1021/acs.orglett.8b03964

MnCl2-Catalyzed C–H Alkylation on Azine Heterocycles
Org. Lett., 2019, 21 (2), pp 571–574
DOI: 10.1021/acs.orglett.8b03924

Synthesis of the C1–C19 Domain of Azaspiracid-34
Org. Lett., 2019, 21 (2), pp 356–359
DOI: 10.1021/acs.orglett.8b03451

A Three-Phase Four-Component Coupling Reaction: Selective Synthesis of o-Chloro Benzoates by KCl, Arynes, CO2, and Chloroalkanes
Org. Lett., 2019, 21 (2), pp 345–349
DOI: 10.1021/acs.orglett.8b03193

Copper-Catalyzed C4-H Regioselective Phosphorylation/Trifluoromethylation of Free 1-Naphthylamines
Org. Lett., 2019, 21 (2), pp 486–489
DOI: 10.1021/acs.orglett.8b03768


Organic Process Research & Development

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Some Items of Interest to Process R&D Chemists and Engineers
Org. Process Res. Dev., 2019, 23 (1), pp 1–8
DOI: 10.1021/acs.oprd.8b00457

Multikilogram-Scale Preparation of AZD4635 via C–H Borylation and Bromination: The Corrosion of Tantalum by a Bromine/Methanol Mixture
Org. Process Res. Dev., 2019, 23 (1), pp 62–68
DOI: 10.1021/acs.oprd.8b00342

Efficient and Scalable Synthesis of Glucokinase Activator with a Chiral Thiophenyl-Pyrrolidine Scaffold
Org. Process Res. Dev., 2019, 23 (1), pp 69–77
DOI: 10.1021/acs.oprd.8b00354

Process Development for a Locally Acting SGLT1 Inhibitor, LX2761, Utilizing sp3–sp2 Suzuki Coupling of a Benzyl Carbonate
Org. Process Res. Dev., 2019, 23 (1), pp 45–61
DOI: 10.1021/acs.oprd.8b00325

Biocatalysis Using Immobilized Enzymes in Continuous Flow for the Synthesis of Fine Chemicals
Org. Process Res. Dev., 2019, 23 (1), pp 9–18
DOI: 10.1021/acs.oprd.8b00305


Organometallics

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The Roles of Organometallic Chemistry in Pharmaceutical Research and Development
This article is part of the The Roles of Organometallic Chemistry in Pharmaceutical Research and Development special issue.
Organometallics, 2019, 38 (1), pp 1–2
DOI: 10.1021/acs.organomet.8b00918

What Industrial Chemists Want—Are Academics Giving It to Them?
This article is part of the The Roles of Organometallic Chemistry in Pharmaceutical Research and Development special issue.
Organometallics, 2019, 38 (1), pp 66–75
DOI: 10.1021/acs.organomet.8b00818

Cross-Coupling and Related Reactions: Connecting Past Success to the Development of New Reactions for the Future
This article is part of the The Roles of Organometallic Chemistry in Pharmaceutical Research and Development special issue.
Organometallics,
2019, 38 (1), pp 3–35
DOI: 10.1021/acs.organomet.8b00720

Bonding in Chemistry: Surprising Results from an Ordinary Glovebox
Organometallics, 2019, 38 (2), pp 198–199
DOI: 10.1021/acs.organomet.9b00007

A Pharmaceutical Industry Perspective on Sustainable Metal Catalysis
Organometallics, 2019, 38 (1), pp 36–46
DOI: 10.1021/acs.organomet.8b00566

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