There are lots of different ways to look at the reach of an article. You can look at citations, Altmetric Attention Scores, awards, and more. One way to consider the influence of an article is just by looking at how many people chose to read it. To that end, we’ve compiled lists of the five most-read chemistry articles that appeared in each ACS Publications journal in April 2019, including research, reviews, perspectives, and editorial pieces. These lists were not chosen by the journal’s editors and should not be taken as a “best of” list, but as another perspective on where the chemistry community allocated their attention.
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Read more of April’s most-read articles: Analytical | Applied | Biological | Materials Science & Engineering | Multidisciplinary | Organic/Inorganic | Physical
ACS Catalysis
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Introducing the 2019 Early Career Advisory Board of ACS Catalysis
ACS Catal., 2019, 9 (4), pp 3588–3588
DOI: 10.1021/acscatal.9b01141
Metalloporphyrin Catalyzed C–H Amination
ACS Catal., 2019, 9 (4), pp 3604–3617
DOI: 10.1021/acscatal.9b00009
Phantom Reactivity in Organic and Catalytic Reactions as a Consequence of Microscale Destruction and Contamination-Trapping Effects of Magnetic Stir Bars
ACS Catal., 2019, 9 (4), pp 3070–3081
DOI: 10.1021/acscatal.9b00294
Revealing the Synergy between Oxide and Alloy Phases on the Performance of Bimetallic In–Pd Catalysts for CO2 Hydrogenation to Methanol
ACS Catal., 2019, 9 (4), pp 3399–3412
DOI: 10.1021/acscatal.8b04848
Significant Advances in C1 Catalysis: Highly Efficient Catalysts and Catalytic Reactions
ACS Catal., 2019, 9 (4), pp 3026–3053
DOI: 10.1021/acscatal.8b03924
ACS Combinatorial Science
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Analysis of CH4 Uptake over Metal–Organic Frameworks Using Data-Mining Tools
ACS Comb. Sci., 2019, 21 (4), pp 257–268
DOI: 10.1021/acscombsci.8b00150
Application of Glaser–Hay Diyne Coupling To Constrain Nα-Amino Acid Amides via a N–N Bridge
ACS Comb. Sci., 2019, 21 (4), pp 316–322
DOI: 10.1021/acscombsci.8b00179
Base Controlled Three-Component Regioselective Synthesis of 2-Imino Thiazolines and 2-Thioxoimidazolin-4-ones
ACS Comb. Sci., 2019, 21 (4), pp 269–275
DOI: 10.1021/acscombsci.8b00152
Biophysical Characterization Platform Informs Protein Scaffold Evolvability
Open Access Through ACS Editors’ Choice
ACS Comb. Sci., 2019, 21 (4), pp 323–335
DOI: 10.1021/acscombsci.8b00182
Dynamical Correlations for Statistical Copolymers from High-Throughput Broad-Band Dielectric Spectroscopy
ACS Comb. Sci., 2019, 21 (4), pp 276–299
DOI: 10.1021/acscombsci.8b00160
ACS Medicinal Chemistry Letters
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Behind the Mirror: Chirality Tunes the Reactivity and Cytotoxicity of Chloropiperidines as Potential Anticancer Agents
Open Access Through ACS AuthorChoice
ACS Med. Chem. Lett., 2019, 10 (4), pp 552–557
DOI: 10.1021/acsmedchemlett.8b00580
Bioisosteres of Indomethacin as Inhibitors of Aldo-Keto Reductase 1C3
ACS Med. Chem. Lett., 2019, 10 (4), pp 437–443
DOI: 10.1021/acsmedchemlett.8b00484
Cannabinoids from Cannabis sativa L.: A New Tool Based on HPLC–DAD–MS/MS for a Rational Use in Medicinal Chemistry
This article is part of the Highlighting Medicinal Chemistry in Italy special issue.
ACS Med. Chem. Lett., 2019, 10 (4), pp 539–544
DOI: 10.1021/acsmedchemlett.8b00571
Discovery of 1,4-Naphthoquinones as a New Class of Antiproliferative Agents Targeting GPR55
This article is part of the Highlighting Medicinal Chemistry in Italy special issue.
ACS Med. Chem. Lett., 2019, 10 (4), pp 402–406
DOI: 10.1021/acsmedchemlett.8b00333
Drug Design and Synthesis of First in Class PDZ1 Targeting NHERF1 Inhibitors as Anticancer Agents
This article is part of the Highlighting Medicinal Chemistry in Italy special issue.
Open Access Through ACS AuthorChoice
ACS Med. Chem. Lett., 2019, 10 (4), pp 499–503
DOI: 10.1021/acsmedchemlett.8b00532
Bioconjugate Chemistry
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A Metal-Free DOTA-Conjugated 18F-Labeled Radiotracer: [18F]DOTA-AMBF3-LLP2A for Imaging VLA-4 Over-Expression in Murine Melanoma with Improved Tumor Uptake and Greatly Enhanced Renal Clearance
Bioconjugate Chem., 2019, 30 (4), pp 1210–1219
DOI: 10.1021/acs.bioconjchem.9b00146
Antibody Delivery for Intracellular Targets: Emergent Therapeutic Potential
Bioconjugate Chem., 2019, 30 (4), pp 1028–1041
DOI: 10.1021/acs.bioconjchem.9b00025
Dual Synthetic Peptide Conjugate Vaccine Simultaneously Triggers TLR2 and NOD2 and Activates Human Dendritic Cells
Open Access Through ACS AuthorChoice
Bioconjugate Chem., 2019, 30 (4), pp 1150–1161
DOI: 10.1021/acs.bioconjchem.9b00087
Dual-Bioorthogonal Molecular Tool: “Click-to-Release” and “Double-Click” Reactivity on Small Molecules and Material Surfaces
Bioconjugate Chem., 2019, 30 (4), pp 1140–1149
DOI: 10.1021/acs.bioconjchem.9b00078
Harnessing Exosomes for the Development of Brain Drug Delivery Systems
Bioconjugate Chem., 2019, 30 (4), pp 994–1005
DOI: 10.1021/acs.bioconjchem.9b00085
Inorganic Chemistry
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A Chromium-Substituted Polyoxoniobate with High Ionic Conductivity
Inorg. Chem., 2019, 58 (7), pp 4055–4058
DOI: 10.1021/acs.inorgchem.8b03529
C–N Coupling in N2 Fixation by the Ditantalum Carbide Cluster Anions Ta2C4–
Inorg. Chem., 2019, 58 (8), pp 4701–4705
DOI: 10.1021/acs.inorgchem.8b03502
En Route Activity of Hydration Water Allied with Uranyl (UO22+) Salts Amid Complexation Reactions with an Organothio-Based (O, N, S) Donor Base
Inorg. Chem., 2019, 58 (8), pp 4972–4978
DOI: 10.1021/acs.inorgchem.8b03622
Flexible-Ligand-Based Self-adaptive Metal–Organic Material for Supramolecular Selective Recognition of Similar Natural Molecules
Inorg. Chem., 2019, 58 (7), pp 4067–4070
DOI: 10.1021/acs.inorgchem.9b00148
Grinding-Triggered Single Crystal-to-Single Crystal Transformation of a Zinc(II) Complex: Mechanochromic Luminescence and Aggregation-Induced Emission Properties
Inorg. Chem., 2019, 58 (7), pp 4626–4633
DOI: 10.1021/acs.inorgchem.9b00195
Journal of Medicinal Chemistry
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Design of N-Benzoxaborole Benzofuran GSK8175—Optimization of Human Pharmacokinetics Inspired by Metabolites of a Failed Clinical HCV Inhibitor
J. Med. Chem., 2019, 62 (7), pp 3254–3267
DOI: 10.1021/acs.jmedchem.8b01719
Development of Covalent Ligands for G Protein-Coupled Receptors: A Case for the Human Adenosine A3 Receptor
Open Access Through ACS AuthorChoice
J. Med. Chem., 2019, 62 (7), pp 3539–3552
DOI: 10.1021/acs.jmedchem.8b02026
Discovery of Branebrutinib (BMS-986195): A Strategy for Identifying a Highly Potent and Selective Covalent Inhibitor Providing Rapid in Vivo Inactivation of Bruton’s Tyrosine Kinase (BTK)
J. Med. Chem., 2019, 62 (7), pp 3228–3250
DOI: 10.1021/acs.jmedchem.9b00167
Discovery of Novel Spiroindoline Derivatives as Selective Tankyrase Inhibitors
J. Med. Chem., 2019, 62 (7), pp 3407–3427
DOI: 10.1021/acs.jmedchem.8b01888
FragLites—Minimal, Halogenated Fragments Displaying Pharmacophore Doublets. An Efficient Approach to Druggability Assessment and Hit Generation
J. Med. Chem., 2019, 62 (7), pp 3741–3752
DOI: 10.1021/acs.jmedchem.9b00304
Journal of Natural Products
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Acylated Lignans Isolated from Brachanthemum gobicum and Their Trypanocidal Activity
J. Nat. Prod., 2019, 82 (4), pp 774–784
DOI: 10.1021/acs.jnatprod.8b00670
Anti-inflammatory Lathyrane Diterpenoids from Euphorbia lathyris
J. Nat. Prod., 2019, 82 (4), pp 756–764
DOI: 10.1021/acs.jnatprod.8b00600
Camporidines A and B: Antimetastatic and Anti-inflammatory Polyketide Alkaloids from a Gut Bacterium of Camponotus kiusiuensis
J. Nat. Prod., 2019, 82 (4), pp 903–910
DOI: 10.1021/acs.jnatprod.8b01000
Diazaquinomycin Biosynthetic Gene Clusters from Marine and Freshwater Actinomycetes
J. Nat. Prod., 2019, 82 (4), pp 937–946
DOI: 10.1021/acs.jnatprod.8b01028
Inducing Secondary Metabolite Production by Co-culture of the Endophytic Fungus Phoma sp. and the Symbiotic Fungus Armillaria sp.
J. Nat. Prod., 2019, 82 (4), pp 1009–1013
DOI: 10.1021/acs.jnatprod.8b00685
The Journal of Organic Chemistry
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Excellence in Industrial Organic Synthesis 2019: The Past, Present, and Future
This article is part of the Excellence in Industrial Organic Synthesis 2019 special issue.
J. Org. Chem., 2019, 84 (8), pp 4577–4579
DOI: 10.1021/acs.joc.9b00847
Greening Organic Chemistry with Process Chemistry
This article is part of the Excellence in Industrial Organic Synthesis 2019 special issue.
J. Org. Chem., 2019, 84 (8), pp 4580–4582
DOI: 10.1021/acs.joc.9b00344
Halide-Controlled Extending–Shrinking Motion of a Covalent Cage
This article is part of the Excellence in Industrial Organic Synthesis 2019 special issue.
J. Org. Chem., 2019, 84 (7), pp 4221–4228
DOI: 10.1021/acs.joc.9b00219
Impact of Methoxy Substituents on Thermally Activated Delayed Fluorescence and Room-Temperature Phosphorescence in All-Organic Donor–Acceptor Systems
This article is part of the Excellence in Industrial Organic Synthesis 2019 special issue.
J. Org. Chem., 2019, 84 (7), pp 3801–3816
DOI: 10.1021/acs.joc.8b02848
Molecular Complexity as a Driver for Chemical Process Innovation in the Pharmaceutical Industry
This article is part of the Excellence in Industrial Organic Synthesis 2019 special issue.
J. Org. Chem., 2019, 84 (8), pp 4583–4603
DOI: 10.1021/acs.joc.9b00735
Molecular Pharmaceutics
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Computational Techniques for Predicting Mechanical Properties of Organic Crystals: A Systematic Evaluation
Mol. Pharmaceutics, 2019, 16 (4), pp 1732–1741
DOI: 10.1021/acs.molpharmaceut.9b00082
Correction to “Polymer-Mediated Drug Supersaturation Controlled by Drug–Polymer Interactions Persisting in an Aqueous Environment”
Mol. Pharmaceutics, 2019, 16 (4), pp 1787–1787
DOI: 10.1021/acs.molpharmaceut.9b00229
Correction to “Potential Eye Drop Based on a Calix[4]arene Nanoassembly for Curcumin Delivery: Enhanced Drug Solubility, Stability, and Anti-Inflammatory Effect
Mol. Pharmaceutics, 2019, 16 (4), pp 1788–1788
DOI: 10.1021/acs.molpharmaceut.9b00299
Impact of Ferroquine on the Solubilization of Artefenomel (OZ439) during in Vitro Lipolysis in Milk and Implications for Oral Combination Therapy for Malaria
Open Access Through ACS AuthorChoice
Mol. Pharmaceutics, 2019, 16 (4), pp 1658–1668
DOI: 10.1021/acs.molpharmaceut.8b01333
Microstructure Formation for Improved Dissolution Performance of Lopinavir Amorphous Solid Dispersions
Mol. Pharmaceutics, 2019, 16 (4), pp 1751–1765
DOI: 10.1021/acs.molpharmaceut.9b00117
Organic Letters
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A Concise Asymmetric Total Synthesis of (+)-Epilupinine
Org. Lett., 2019, 21 (8), pp 2620–2624
DOI: 10.1021/acs.orglett.9b00607
Asymmetric Total Syntheses and Biological Studies of Tuberostemoamide and Sessilifoliamide A
Org. Lett., 2019, 21 (8), pp 2952–2956
DOI: 10.1021/acs.orglett.9b01042
Copper-Catalyzed C–H Carbamoyloxylation of Aryl Carboxamides with CO2 and Amines at Ambient Conditions
Org. Lett., 2019, 21 (7), pp 2013–2018
DOI: 10.1021/acs.orglett.9b00122
Diastereoselective Intramolecular Hydride Transfer under Brønsted Acid Catalysis
Open Access Through ACS Editors’ Choice
Org. Lett., 2019, 21 (7), pp 2298–2301
DOI: 10.1021/acs.orglett.9b00590
Ni-catalyzed Reductive Deaminative Arylation at sp3 Carbon Centers
Org. Lett., 2019, 21 (8), pp 2947–2951
DOI: 10.1021/acs.orglett.9b01016
Organic Process Research & Development
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Catalytic Deprotonative α-Formylation of Heteroarenes by an Amide Base Generated in Situ from Tetramethylammonium Fluoride and Tris(trimethylsilyl)amine
This article is part of the Japanese Society for Process Chemistry special issue.
Org. Process Res. Dev., 2019, 23 (4), pp 443–451
DOI: 10.1021/acs.oprd.8b00247
Development of a Synthetic Process for K-8986, an H1-Receptor Antagonist
This article is part of the Japanese Society for Process Chemistry special issue.
Org. Process Res. Dev., 2019, 23 (4), pp 470–476
DOI: 10.1021/acs.oprd.8b00380
Development of an Efficient Manufacturing Process for a Key Intermediate in the Synthesis of Edoxaban
This article is part of the Japanese Society for Process Chemistry special issue.
Org. Process Res. Dev., 2019, 23 (4), pp 524–534
DOI: 10.1021/acs.oprd.8b00413
Development of Asymmetric Transfer Hydrogenation with a Bifunctional Oxo-Tethered Ruthenium Catalyst in Flow for the Synthesis of a Ceramide (d-erythro-CER[NDS])
This article is part of the Japanese Society for Process Chemistry special issue.
Org. Process Res. Dev., 2019, 23 (4), pp 452–461
DOI: 10.1021/acs.oprd.8b00338
Efficient Azacycle Formations Developed in Japanese Pharmaceutical Industries: Elegancy, Logistics, and Training (ELT) “Sandwich” for Process Chemists
This article is part of the Japanese Society for Process Chemistry special issue.
Org. Process Res. Dev., 2019, 23 (4), pp 419–442
DOI: 10.1021/acs.oprd.8b00412
Organometallics
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A Highly Active Catalyst System for Suzuki–Miyaura Coupling of Aryl Chlorides
Organometallics, 2019, 38 (7), pp 1459–1467
DOI: 10.1021/acs.organomet.8b00883
Associative Ligand Exchange and Substrate Activation Reactions by a Zero-Valent Cobalt Tetraisocyanide Complex
Organometallics, 2019, 38 (7), pp 1436–1444
DOI: 10.1021/acs.organomet.8b00777
Dehydrogenative Coupling of Aldehydes with Alcohols Catalyzed by a Nickel Hydride Complex
Organometallics, 2019, 38 (7), pp 1468–1478
DOI: 10.1021/acs.organomet.8b00888
Preparation of Ni(cod)2 Using Light as the Source of Energy
Organometallics, 2019, 38 (7), pp 1413–1416
DOI: 10.1021/acs.organomet.9b00057
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