Stay up to date with a selection of recently published articles from ACS journals that were among the most read in December 2025.
The impact of a scientific article can be assessed in many ways, and one key indicator of reach and influence is its readership. Here, we present a curated list of 10 most-read chemistry articles during December 2025, showcasing influential and trending research across ACS journals.*
We hope you find these articles insightful and valuable. If you want to learn more about publishing in our journals, click below to discover how your own research can further our commitment to being the “Most Trusted. Most Cited. Most Read.”
Browse Highly Read ACS Journal Articles in December 2025
Total Synthesis of Aconicarmisulfonine A, a Sulfonated Diterpene Alkaloid
Shang Ning and Thomas J. Maimone*
DOI: 10.1021/jacs.5c17047
DOI: 10.1021/jacs.5c17047
Unleashing the Power of Potassium 2-Ethylhexanoate as a Mild and Soluble Base for Pd-Catalyzed C–N Cross-Coupling
William D. Lambert, Stephanie Felten, Nicholas Hadler, N. Ian Rinehart, Rafal Swiatowiec, Gregory E. Storer, Jeremy Henle, Mark A. Servos, Cassie Yang, Anna V. Bay, Pascal N. Eyimegwu, Shashank Shekhar*, and John Hartwig*
DOI: 10.1021/jacs.5c07790
DOI: 10.1021/jacs.5c07790
α-Gal Causes Tick-Related Meat Allergies─It Could Also Be a Therapeutic
Marta Zaraska
DOI: 10.1021/acscentsci.5c02233
DOI: 10.1021/acscentsci.5c02233
Unified Total Synthesis of C2-Symmetric Bis(cyclotryptamine) Alkaloids Utilizing a Single-Atom Insertion/Deletion Strategy
Hiroki Yamagishi, David W. Small, and Richmond Sarpong*
DOI: 10.1021/jacs.5c15181
DOI: 10.1021/jacs.5c15181
Carbonylative Ring Expansion of Cyclic Carboxylic Acids
Hiroki Shimono, Mayu Kusakabe, Kazunori Nagao*, and Hirohisa Ohmiya*
DOI: 10.1021/jacs.5c08640
DOI: 10.1021/jacs.5c08640
Band-Pass Raman Spectroscopy Unlocks Compact Point-of-Care Noninvasive Continuous Glucose Monitoring
Arianna Bresci, Youngkyu Kim, Miyeon Jue, Peter T. C. So, and Jeon Woong Kang*
DOI: 10.1021/acs.analchem.5c01146
DOI: 10.1021/acs.analchem.5c01146
A Pragmatic Radical Strategy for Dearomative Hydroalkylation of Unactivated Indoles
Chao Hu, Renzhe Li, Rohan R. Merchant, Yuzuru Kanda, and Tian Qin*
DOI: 10.1021/jacs.5c17556
DOI: 10.1021/jacs.5c17556
Solvent Sustainability in Drug Discovery: Where Are We Now, and How Can We Improve?
Paul Richardson*, Marian C. Bryan, Louis Diorazio, Fabrice Gallou, Shazia Keily, Isamir Martinez, Scott Plummer, Anthony B. Reed, Robert Sheppard, Jason Shields, Gail Wrigley, Charles Yeung, and Álvaro Enríquez-García*
DOI: 10.1021/acs.jmedchem.5c01220
DOI: 10.1021/acs.jmedchem.5c01220
Air-Stable Tetrazene Radical Cation Salts: Structural Requirements and Oxidation Catalysts
Ayari Oshiro, Yusuke Sasano*, Shu Saito, Yasuyuki Araki, Soichiro Sugiyama, Eunsang Kwon, Shinji Kajimoto, Yuse Kuriyama, Shohei Yoshinaga, Masaya Takahashi, Katsuhiko Sato, Naoki Shida, Yusuke Ishigaki, Mahito Atobe, and Yoshiharu Iwabuchi*
DOI: 10.1021/jacs.5c15272
DOI: 10.1021/jacs.5c15272
Thianthrenium Chemistry for Identification of Protein–Protein Interactions in Cells
Kostiantyn Bohdan, Philipp Hartmann, Sven Müller, Dario Marchionni, Christian Preisinger, Julia Beatrice Jacobs, Lara Vogelsang, Marie Sophie Sterling, Karl-Josef Dietz, and Tobias Ritter*
DOI: 10.1021/jacs.5c16665
DOI: 10.1021/jacs.5c16665
*These lists are not chosen by the journals’ editors and should not be taken as a “best of” collection, but as another perspective on what recently published research attracted the most attention in a particular month.
