Stay up to date with a selection of recently published articles from ACS journals that were among the most read in October 2025.
The impact of a scientific article can be assessed in many ways, and one key indicator of reach and influence is its readership. Here, we present a curated list of 10 most-read chemistry articles during October 2025, showcasing influential and trending research across ACS journals.*
We hope you find these articles insightful and valuable. If you want to learn more about publishing in our journals, click below to discover how your own research can further our commitment to being the “Most Trusted. Most Cited. Most Read.”
Browse Highly Read ACS Journal Articles in October 2025
Discovery of Late Intermediates in Methylenomycin Biosynthesis Active against Drug-Resistant Gram-Positive Bacterial Pathogens
Christophe Corre, Gideon A. Idowu, Lijiang Song, Melanie E. Whitehead, Lona M. Alkhalaf*, and Gregory L. Challis*
DOI: 10.1021/jacs.5c12501
DOI: 10.1021/jacs.5c12501
A Simplified, One-Pot, Procedure for the Deoxygenative Alkylation of Aryl Bromides
Shane Plunkett*, Justin B. Diccianni*, James Mulhearn, and Soo Choi
DOI: 10.1021/acs.orglett.5c03643
DOI: 10.1021/acs.orglett.5c03643
Deoxygenative C(sp3)–N(sp3) Cross-Coupling Enabled by Nickel Metallaphotoredox Catalysis
Ruizhe Chen, Taehyun Kim, Noah B. Bissonnette, Robert T. Martin, Joseph R. Martinelli, Albert Cabré, and David W. C. MacMillan*
DOI: 10.1021/jacs.5c10915
DOI: 10.1021/jacs.5c10915
33 Unresolved Questions in Nanoscience and Nanotechnology
Chad A. Mirkin*, Sarah Hurst Petrosko, Natalie Artzi, Koray Aydin, Austin Biaggne, C. Jeffrey Brinker, Katherine E. Bujold, Y. Charles Cao, Rachel R. Chan, Chaojian Chen et al.
DOI: 10.1021/acsnano.5c12854
DOI: 10.1021/acsnano.5c12854
Review on Metal–Organic Framework Classification, Synthetic Approaches, and Influencing Factors: Applications in Energy, Drug Delivery, and Wastewater Treatment
Vadia Foziya Yusuf, Naved I. Malek, and Suresh Kumar Kailasa*
DOI: 10.1021/acsomega.2c05310
DOI: 10.1021/acsomega.2c05310
Discovery of Lenacapavir: First-in-Class Twice-Yearly Capsid Inhibitor for HIV-1 Treatment and Pre-exposure Prophylaxis
Eda Canales*, Winston Tse, Scott D. Schroeder, Chien-Hung Chou, Qi Liu, Jennifer Zhang, Scott E. Lazerwith, Philip Morganelli, Roland D. Saito, Gediminas Brizgys et al.
DOI: 10.1021/acs.jmedchem.5c01625
DOI: 10.1021/acs.jmedchem.5c01625
Functional Group Transposition Enabled by Palladium and Photo Dual Catalysis
Menghua Xu, Chengjun Wu, and Ming Chen*
DOI: 10.1021/jacs.5c11429
DOI: 10.1021/jacs.5c11429
Enantioselective Synthesis of (+)-Auriculatol A
Jordan K. Thompson, Kala C. Youngblood, Yun Hao Shawn Teh, Conner M. Farley, Zhehao Zhang, Scott C. Virgil, and Sarah E. Reisman*
DOI: 10.1021/jacs.5c17269
DOI: 10.1021/jacs.5c17269
Challenges of Aufheben to Promote Druglikeness: Chemical Modification Strategies to Improve Aqueous Solubility and Permeability
Minoru Ishikawa*, Shusuke Tomoshige, and Shinichi Sato
DOI: 10.1021/acs.jmedchem.5c00287
DOI: 10.1021/acs.jmedchem.5c00287
Intranasal Delivery of Ivermectin Nanosystems as an Antitumor Agent: Focusing on Glioma Suppression
Maiara Callegaro Velho, Valeria Luiza Winck, Camila da Silveira Mariot, Juliete Nathali Scholl, Augusto Ferreira Weber, Rita de Kássia Souza, Fernanda Visioli, Fabrício Figueiró, Monique Deon, Diogo André Pilger, and Ruy Carlos Ruver Beck*
DOI: 10.1021/acsbiomaterials.5c00642
DOI: 10.1021/acsbiomaterials.5c00642
*These lists are not chosen by the journals’ editors and should not be taken as a “best of” collection, but as another perspective on what recently published research attracted the most attention in a particular month.
