Stay up to date with a selection of recently published articles from ACS journals that were among the most read in February 2026.
The impact of a scientific article can be assessed in many ways, and one key indicator of reach and influence is its readership. Here, we present a curated list of 10 most-read chemistry articles during February 2026, showcasing influential and trending research across ACS journals.*
We hope you find these articles insightful and valuable. If you want to learn more about publishing in ACS journals, click below to learn more and discover the best fit for your research.
Browse Highly Read ACS Journal Articles in February 2026
Overriding Stereochemical Outcomes in Cyclase Phase Total Synthesis: Enantioselective Synthesis of Habiterpenol and Dasyscyphin A
Licheng Wu, Long H. Nguyen, Liwen Yan, Haoyu Yin, Natsuki Mizuno, and Alexander W. Schuppe*
DOI: 10.1021/jacs.6c00141
DOI: 10.1021/jacs.6c00141
From Prompt to Drug: Toward Pharmaceutical Superintelligence
Alex Zhavoronkov*, David Gennert, and Jiye Shi*
DOI: 10.1021/acscentsci.5c01473
DOI: 10.1021/acscentsci.5c01473
Total Synthesis of (±)-Dhilirolide U
Henrik R. Wilke, Marlene Fadel, Kacper J. Patej, Jan P. Prohaska, Jonathan Kastner, Veronika Avramenko, Oscar Garcia Gonzalez, Rüveyda Bal, Matteo C. Amberg, Jameel Ahmad, Nima Nasiri, Tobias K. Jenny, and Erick M. Carreira*
DOI: 10.1021/jacs.5c22734
DOI: 10.1021/jacs.5c22734
The Heterocycle Isostere Explorer: A Computational Tool for the Discovery of Novel Aromatic Heterocyclic Isosteres
Matthew T. O. Holland, Víctor Sebastián-Pérez, Anthony R. Bradley, Fernanda Duarte, and Paul E. Brennan*
DOI: 10.1021/acs.jmedchem.5c03118
DOI: 10.1021/acs.jmedchem.5c03118
Mechanism-Inspired Ligand Design for Efficient Copper-Catalyzed C–N Coupling of Aryl and Heteroaryl Chlorides
Wei Zhao, Willi M. Amberg, Guodong Rao, Yuanzhe Xie, Christina N. Pierson, Serena M. Fantasia, Stephan M. Rummelt, Kurt Püntener, R. David Britt, and John F. Hartwig*
DOI: 10.1021/jacs.5c20640
DOI: 10.1021/jacs.5c20640
Identifying Chemicals of Health Concern in Hair Extensions Using Suspect Screening and Nontargeted Analysis
Elissia T. Franklin*, Kristin Favela, Radonna Spies, Jacqueline M. Ranger, and Ruthann A. Rudel
DOI: 10.1021/envhealth.5c00549
DOI: 10.1021/envhealth.5c00549
Potassium Bisulfite’s Role in Developing a Robust Platform for Enantioenriched N-Alkylpyridinium Salts as Piperidine Precursors
Jake D. Selingo, Jacob R. King, Barbara Pio, Andrew J. Neel, Yu-Hong Lam, Robert S. Paton, Matthew L. Maddess*, and Andrew McNally*
DOI: 10.1021/jacs.5c20464
DOI: 10.1021/jacs.5c20464
The Affinity Advantage
Mark A. Murcko*
DOI: 10.1021/acs.jmedchem.5c03222
DOI: 10.1021/acs.jmedchem.5c03222
How Alkali Metal Alkoxides Initiate Organic Radical Reactions
Seb Tyerman, Kenneth F. Clark, Alexander J. Stewart, Krystian Kolodziejczak, Craig M. Robertson, Laura Evans, Alan R. Kennedy, Tell Tuttle, David J. Nelson*, and John A. Murphy*
DOI: 10.1021/jacs.5c22122
DOI: 10.1021/jacs.5c22122
Anode-Free Batteries: Pioneering Energy Storage Revolution
Yosef Nikodimos*, Kassie Nigus Shitaw, Teklay Mezgebe Hagos, Tsung-I Yeh, Yu-Chun Huang, Chia-Lung Hsieh, Hsuan-Hsuan Su, Wei-Nien Su*, and Bing Joe Hwang*
DOI: 10.1021/acs.chemrev.5c00533
DOI: 10.1021/acs.chemrev.5c00533
*These lists are not chosen by the journals’ editors and should not be taken as a “best of” collection, but as another perspective on what articles attracted the most attention in a particular month.
