Stay up to date with a selection of recently published articles from ACS journals that were among the most read in March 2025.
The impact of a scientific article can be assessed in many ways, and one key indicator of reach and influence is its readership. Here, we present a curated list of 10 most-read chemistry articles during March 2025, showcasing influential and trending research across ACS journals.*
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Most-Read ACS Journal Articles: March 2025
Discovery of Daraxonrasib (RMC-6236), a Potent and Orally Bioavailable RAS(ON) Multi-selective, Noncovalent Tri-complex Inhibitor for the Treatment of Patients with Multiple RAS-Addicted Cancers
James Cregg*, Anne V. Edwards, Stephanie Chang, Bianca J. Lee, John E. Knox, Aidan C. A. Tomlinson, Abby Marquez, Yang Liu, Rebecca Freilich, Naing Aay, Yingyun Wang, Lingyan Jiang, Jingjing Jiang, Zhican Wang, Michael Flagella, David Wildes, Jacqueline A.M. Smith, Mallika Singh, Zhengping Wang, Adrian L. Gill, and Elena S. Koltun*
DOI: 10.1021/acs.jmedchem.4c02314
DOI: 10.1021/acs.jmedchem.4c02314
N-Protonated Acridinium Catalyst Enables Anti-Markovnikov Hydration of Unconjugated Tri- and Disubstituted Olefins
Boris Alexander van der Worp and Tobias Ritter*
DOI: 10.1021/jacs.4c18185
DOI: 10.1021/jacs.4c18185
Topological Superconductors from a Materials Perspective
Manasi Mandal*, Nathan C. Drucker, Phum Siriviboon, Thanh Nguyen, Artittaya Boonkird, Tej Nath Lamichhane, Ryotaro Okabe, Abhijatmedhi Chotrattanapituk, and Mingda Li*
DOI: 10.1021/acs.chemmater.3c00713
DOI: 10.1021/acs.chemmater.3c00713
Free Drug Concepts: A Lingering Problem in Drug Discovery
Peter J. H. Webborn*, Kevin Beaumont, Iain J. Martin, and Dennis A. Smith
DOI: 10.1021/acs.jmedchem.5c00725
DOI: 10.1021/acs.jmedchem.5c00725
Surface-Enhanced Raman Spectroscopy for Biomedical Applications: Recent Advances and Future Challenges
Linley Li Lin, Ramon Alvarez-Puebla, Luis M. Liz-Marzán, Matt Trau, Jing Wang, Laura Fabris, Xiang Wang, Guokun Liu, Shuping Xu, Xiao Xia Han, Liangbao Yang, Aiguo Shen, Shikuan Yang, Yikai Xu, Chunchun Li, Jinqing Huang, Shao-Chuang Liu, Jian-An Huang, Indrajit Srivastava, Ming Li, Limei Tian, Lam Bang Thanh Nguyen, Xinyuan Bi, Dana Cialla-May, Pavel Matousek, Nicholas Stone, Randy P. Carney, Wei Ji, Wei Song, Zhou Chen, In Yee Phang, Malou Henriksen-Lacey, Haoran Chen, Zongyu Wu, Heng Guo, Hao Ma, Gennadii Ustinov, Siheng Luo, Sara Mosca, Benjamin Gardner, Yi-Tao Long, Juergen Popp, Bin Ren, Shuming Nie, Bing Zhao, Xing Yi Ling*, and Jian Ye*
DOI: 10.1021/acsami.4c17502
DOI: 10.1021/acsami.4c17502
Photocatalyzed Epimerization of Quaternary Stereocenters
Licheng Wu, Baylee N. McIntyre, Supeng Wu, Ziqi Jiao, Carter B. Fox, Nathan D. Schley, and Alexander W. Schuppe*
DOI: 10.1021/jacs.4c16769
DOI: 10.1021/jacs.4c16769
Flame-Free Candles Are Not Pollution-Free: Scented Wax Melts as a Significant Source of Atmospheric Nanoparticles
Satya S. Patra, Jinglin Jiang, Jianghui Liu, Gerhard Steiner, Nusrat Jung*, and Brandon E. Boor*
DOI: 110.1021/acs.estlett.4c00986
DOI: 110.1021/acs.estlett.4c00986
Introductory Tutorials for Simulating Protein Dynamics with GROMACS
Justin A. Lemkul*
DOI: 10.1021/acs.jpcb.4c04901
DOI: 10.1021/acs.jpcb.4c04901
Total Synthesis of Enlicitide Decanoate
Hongming Li, David A. Thaisrivongs*, Gao Shang*, Yonggang Chen, Qinghao Chen, Lushi Tan, Kai-Jiong Xiao, Reed T. Larson, Jeffrey T. Kuethe, Joshua Lee, Nicholas R. Deprez, Andrew F. Nolting, Marc Poirier, Paul G. Bulger, Erik L. Regalado, Mirlinda Biba, Fuh-Rong Tsay, Jimmy DaSilva, Chris K. Prier, Christopher A. Strulson, Kerstin Zawatzky, Zhu Liu, Justin A. Newman, Kathleen Sokolowsky, Weijuan Tang, Kari Hullen, Nimisha Thakur, Cody Welch, Smit Patel, Yu He, Jing Xu, Narayan Variankaval, Artis Klapars, Jongrock Kong, Richard Desmond, Richard Varsolona, Peter E. Maligres, Carlos A. Pons Siepermann, Lee Robison, Tiffany Piou, Clara Hartmanshenn, Anagha Chandra, Anisha Patel, Marc R. Becker, Guiquan Liu, Jianjun Duan, Baoqiang Wan, Chengqian Xiao, Yongpeng Yuan, Xiaohui Cao, Lu Chen, Ruxia Yi, Zheng Wu, Minyi Feng, Donghong Li, Zhiyan Song, Yawei Dong, Julin Sun, Biao Li, Guangxin Shao, Louis-Charles Campeau, and Jingjun Yin
DOI: 10.1021/jacs.4c15966
DOI: 10.1021/jacs.4c15966
Synthetic Approaches to the New Drugs Approved during 2023
Scott P. France, Erick A. Lindsey, Emma L. McInturff*, Simon Berritt, Jacob DeForest, Andrew C. Flick, Sarah Fink, Tony S. Gibson, Kaitlyn Gray, Aran K. Hubbell, Amber M. Johnson, Yiyang Liu, Subham Mahapatra, Rebecca B. Watson, and Zhiyao Zhou
DOI: 10.1021/acs.jmedchem.4c02079
DOI: 10.1021/acs.jmedchem.4c02079
*These lists are not chosen by the journals’ editors and should not be taken as a “best of” collection, but as another perspective on what recently published research attracted the most attention in a particular month.
