Discover the Most-Read Biological Chemistry Articles of March 2019

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Latest Progress in Electrospun Nanofibers for Wound Healing Applications
ACS Appl. Bio Mater., 2019, 2 (3), pp 952–969
DOI: 10.1021/acsabm.8b00637

Macrophage-Assisted Dissolution of Gold Nanoparticles
Open Access Through ACS AuthorChoice
ACS Appl. Bio Mater., 2019, 2 (3), pp 1006–1016
DOI: 10.1021/acsabm.8b00537

A Mitochondria-Targeted Ratiometric Fluorescent pH Probe
ACS Appl. Bio Mater., 2019, 2 (3), pp 1368–1375
DOI: 10.1021/acsabm.9b00061

Self-Assembled Metal–Organic Complexes for Thermally Reversible Permeabilization of Cell Membranes
ACS Appl. Bio Mater., 2019, 2 (3), pp 970–974
DOI: 10.1021/acsabm.8b00720

Self-Assembled Porphyrin-Based Nanoparticles with Enhanced Near-Infrared Absorbance for Fluorescence Imaging and Cancer Photodynamic Therapy
ACS Appl. Bio Mater., 2019, 2 (3), pp 999–1005
DOI: 10.1021/acsabm.8b00530

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Recent Strategies in Extrusion-Based Three-Dimensional Cell Printing toward Organ Biofabrication
ACS Biomater. Sci. Eng., 2019, 5 (3), pp 1150–1169
DOI: 10.1021/acsbiomaterials.8b00691

Synthesis and Biomedical Applications of Copper Oxide Nanoparticles: An Expanding Horizon
ACS Biomater. Sci. Eng., 2019, 5 (3), pp 1170–1188
DOI: 10.1021/acsbiomaterials.8b01092

Matrix Metalloproteinase-Deactivating Contact Lens for Corneal Melting
ACS Biomater. Sci. Eng., 2019, 5 (3), pp 1195–1199
DOI: 10.1021/acsbiomaterials.8b01404

Synergistic Effects of Silicon/Zinc Doped Brushite and Silk Scaffolding in Augmenting the Osteogenic and Angiogenic Potential of Composite Biomimetic Bone Grafts
ACS Biomater. Sci. Eng., 2019, 5 (3), pp 1462–1475
DOI: 10.1021/acsbiomaterials.8b01350

Acid-Triggered in Situ Aggregation of Gold Nanoparticles for Multimodal Tumor Imaging and Photothermal Therapy
ACS Biomater. Sci. Eng., 2019, 5 (3), pp 1589–1601
DOI: 10.1021/acsbiomaterials.8b01623

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Catalysis by Metal Organic Frameworks: Perspective and Suggestions for Future Research
ACS Catal., 2019, 9 (3), pp 1779–1798
DOI: 10.1021/acscatal.8b04515

In Situ/Operando Techniques for Characterization of Single-Atom Catalysts
ACS Catal., 2019, 9 (3), pp 2521–2531
DOI: 10.1021/acscatal.8b04937

Development of Tandem Catalysts for CO2 Hydrogenation to Olefins
ACS Catal., 2019, 9 (3), pp 2639–2656
DOI: 10.1021/acscatal.8b05060

Electrochemical Energy Conversion on Intermetallic Compounds: A Review
ACS Catal., 2019, 9 (3), pp 2018–2062
DOI: 10.1021/acscatal.8b04566

PN3(P)-Pincer Complexes: Cooperative Catalysis and Beyond
ACS Catal., 2019, 9 (3), pp 1619–1629
DOI: 10.1021/acscatal.8b04495

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SPR-Measured Dissociation Kinetics of PROTAC Ternary Complexes Influence Target Degradation Rate
Open Access Through ACS Editors’ Choice
ACS Chem. Biol., 2019, 14 (3), pp 361–368
DOI: 10.1021/acschembio.9b00092

PROTAC-Mediated Degradation of Bruton’s Tyrosine Kinase Is Inhibited by Covalent Binding
ACS Chem. Biol., 2019, 14 (3), pp 342–347
DOI: 10.1021/acschembio.8b01094

Fluorescent Retinoic Acid Analogues as Probes for Biochemical and Intracellular Characterization of Retinoid Signaling Pathways
Open Access Through ACS AuthorChoice
ACS Chem. Biol., 2019, 14 (3), pp 369–377
DOI: 10.1021/acschembio.8b00916

Salinipeptins: Integrated Genomic and Chemical Approaches Reveal Unusual d-Amino Acid-Containing Ribosomally Synthesized and Post-Translationally Modified Peptides (RiPPs) from a Great Salt Lake Streptomyces sp.
ACS Chem. Biol., 2019, 14 (3), pp 415–425
DOI: 10.1021/acschembio.8b01058

Metabolic Regulation of the Epitranscriptome
ACS Chem. Biol., 2019, 14 (3), pp 316–324
DOI: 10.1021/acschembio.8b00951

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Facts, Results, and Perspectives of the Current Alzheimer’s Disease Research
ACS Chem. Neurosci., 2019, 10 (3), pp 1127–1128
DOI: 10.1021/acschemneuro.9b00034

Hacking the Brain: Dimensions of Cognitive Enhancement
Open Access Through ACS AuthorChoice
ACS Chem. Neurosci., 2019, 10 (3), pp 1137–1148
DOI: 10.1021/acschemneuro.8b00571

The Curious Case of Human Hippocampal Neurogenesis
ACS Chem. Neurosci., 2019, 10 (3), pp 1131–1132
DOI: 10.1021/acschemneuro.9b00063

Cryo-Electron Microscopy Uncovers Key Residues within the Core of Alpha-Synuclein Fibrils
ACS Chem. Neurosci., 2019, 10 (3), pp 1135–1136
DOI: 10.1021/acschemneuro.9b00090

CoREST Complex-Selective Histone Deacetylase Inhibitors Show Prosynaptic Effects and an Improved Safety Profile To Enable Treatment of Synaptopathies
Open Access Through ACS AuthorChoice
ACS Chem. Neurosci., 2019, 10 (3), pp 1729–1743
DOI: 10.1021/acschemneuro.8b00620

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Elucidation of a Human Urine Metabolite as a Seryl-Leucine Glycopeptide and as a Biomarker of Effective Anti-Tuberculosis Therapy
Open Access Through ACS AuthorChoice
ACS Infect. Dis., 2019, 5 (3), pp 353–364
DOI: 10.1021/acsinfecdis.8b00241

Targeting the Bacterial Epitranscriptome for Antibiotic Development: Discovery of Novel tRNA-(N1G37) Methyltransferase (TrmD) Inhibitors
ACS Infect. Dis., 2019, 5 (3), pp 326–335
DOI: 10.1021/acsinfecdis.8b00275

Single-Cell RNA Sequencing to Understand Host–Pathogen Interactions
ACS Infect. Dis., 2019, 5 (3), pp 336–344
DOI: 10.1021/acsinfecdis.8b00369

Enamide Prodrugs of Acetyl Phosphonate Deoxy-d-xylulose-5-phosphate Synthase Inhibitors as Potent Antibacterial Agents
ACS Infect. Dis., 2019, 5 (3), pp 406–417
DOI: 10.1021/acsinfecdis.8b00307

Small Molecules Targeting the Flavivirus E Protein with Broad-Spectrum Activity and Antiviral Efficacy in Vivo
ACS Infect. Dis., 2019, 5 (3), pp 460–472
DOI: 10.1021/acsinfecdis.8b00322

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PROTAC Molecules for the Treatment of Autoimmune Disorders
ACS Med. Chem. Lett., 2019, 10 (3), pp 276–277
DOI: 10.1021/acsmedchemlett.9b00042

Harnessing Polypharmacology with Medicinal Chemistry
ACS Med. Chem. Lett., 2019, 10 (3), pp 273–275
DOI: 10.1021/acsmedchemlett.9b00039

Idea2Data: Toward a New Paradigm for Drug Discovery
ACS Med. Chem. Lett., 2019, 10 (3), pp 278–286
DOI: 10.1021/acsmedchemlett.8b00488

Identification and Preclinical Evaluation of the Bicyclic Pyrimidine γ-Secretase Modulator BMS-932481
Open Access Through ACS Editors’ Choice
ACS Med. Chem. Lett., 2019, 10 (3), pp 312–317
DOI: 10.1021/acsmedchemlett.8b00541

Atorvastatin (Lipitor) by MCR
Open Access Through ACS AuthorChoice
ACS Med. Chem. Lett., 2019, 10 (3), pp 389–392
DOI: 10.1021/acsmedchemlett.8b00579

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An Automated Data-Driven Pipeline for Improving Heterologous Enzyme Expression
ACS Synth. Biol., 2019, 8 (3), pp 474–481
DOI: 10.1021/acssynbio.8b00486

Network-Based Combinatorial CRISPR-Cas9 Screens Identify Synergistic Modules in Human Cells
ACS Synth. Biol., 2019, 8 (3), pp 482–490
DOI: 10.1021/acssynbio.8b00237

Characterizing Transcriptional Interference between Converging Genes in Bacteria
ACS Synth. Biol., 2019, 8 (3), pp 466–473
DOI: 10.1021/acssynbio.8b00477

Metabolic Engineering of a Homoserine-Derived Non-Natural Pathway for the De Novo Production of 1,3-Propanediol from Glucose
ACS Synth. Biol., 2019, 8 (3), pp 587–595
DOI: 10.1021/acssynbio.9b00003

Construction of Incoherent Feedforward Loop Circuits in a Cell-Free System and in Cells
ACS Synth. Biol., 2019, 8 (3), pp 606–610
DOI: 10.1021/acssynbio.8b00493

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In Silico Protein Design Promotes the Rapid Evolution of Industrial Enzymes
Biochemistry, 2019, 58 (11), pp 1451–1453
DOI: 10.1021/acs.biochem.8b00896

Elements of RNA Design
Biochemistry, 2019, 58 (11), pp 1457–1459
DOI: 10.1021/acs.biochem.8b01129

Synthetic Biology for Fundamental Biochemical Discovery
Biochemistry, 2019, 58 (11), pp 1464–1469
DOI: 10.1021/acs.biochem.8b00915

Diversifying Constrained Peptide Scaffolds: How To Truss Up a Bundle Really Tight
Biochemistry, 2019, 58 (9), pp 1179–1180
DOI: 10.1021/acs.biochem.9b00065

Synthetic Biology for Natural Compounds
Biochemistry, 2019, 58 (11), pp 1454–1456
DOI: 10.1021/acs.biochem.8b00569

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Multivalency in Drug Delivery–When Is It Too Much of a Good Thing?
Bioconjugate Chem., 2019, 30 (3), pp 503–514
DOI: 10.1021/acs.bioconjchem.8b00804

Engineering Protein Delivery Depots for Cancer Immunotherapy
Bioconjugate Chem., 2019, 30 (3), pp 515–524
DOI: 10.1021/acs.bioconjchem.9b00061

Nanoparticle–Peptide–Drug Bioconjugates for Unassisted Defeat of Multidrug Resistance in a Model Cancer Cell Line
Bioconjugate Chem., 2019, 30 (3), pp 525–530
DOI: 10.1021/acs.bioconjchem.8b00755

Tetrazine—trans-Cyclooctene Chemistry Applied to Fabricate Self-Assembled Fluorescent and Radioactive Nanoparticles for in Vivo Dual Mode Imaging
Open Access Through ACS AuthorChoice
Bioconjugate Chem., 2019, 30 (3), pp 547–551
DOI: 10.1021/acs.bioconjchem.9b00038

Bench to Bedside: Albumin Binders for Improved Cancer Radioligand Therapies
Bioconjugate Chem., 2019, 30 (3), pp 487–502
DOI: 10.1021/acs.bioconjchem.8b00919

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Active, Autonomous, and Adaptive Polymeric Particles for Biomedical Applications
Open Access Through ACS AuthorChoice
Biomacromolecules, 2019, 20 (3), pp 1135–1145
DOI: 10.1021/acs.biomac.8b01673

Synthesis and Self-Assembly of Double-Hydrophilic and Amphiphilic Block Glycopolymers
Open Access Through ACS AuthorChoice
Biomacromolecules, 2019, 20 (3), pp 1325–1333
DOI: 10.1021/acs.biomac.8b01713

Protein Adsorption and Coordination-Based End-Tethering of Functional Polymers on Metal–Phenolic Network Films
Biomacromolecules, 2019, 20 (3), pp 1421–1428
DOI: 10.1021/acs.biomac.9b00006

Enhancing the Potency of Antimicrobial Peptides through Molecular Engineering and Self-Assembly
Biomacromolecules, 2019, 20 (3), pp 1362–1374
DOI: 10.1021/acs.biomac.8b01740

Starburst Diblock Polyprodrugs: Reduction-Responsive Unimolecular Micelles with High Drug Loading and Robust Micellar Stability for Programmed Delivery of Anticancer Drugs
Biomacromolecules, 2019, 20 (3), pp 1190–1202
DOI: 10.1021/acs.biomac.8b01566

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Grapevine Red Blotch Virus May Reduce Carbon Translocation Leading to Impaired Grape Berry Ripening
Open Access Through ACS AuthorChoice
J. Agric. Food Chem., 2019, 67 (9), pp 2437–2448
DOI: 10.1021/acs.jafc.8b05555

Intestinal Barrier Function–Non-alcoholic Fatty Liver Disease Interactions and Possible Role of Gut Microbiota
J. Agric. Food Chem., 2019, 67 (10), pp 2754–2762
DOI: 10.1021/acs.jafc.9b00080

Characterization of Orange Oil Powders and Oleogels Fabricated from Emulsion Templates Stabilized Solely by a Natural Triterpene Saponin
J. Agric. Food Chem., 2019, 67 (9), pp 2637–2646
DOI: 10.1021/acs.jafc.8b04588

Production of Triterpene Ginsenoside Compound K in the Non-conventional Yeast Yarrowia lipolytica
J. Agric. Food Chem., 2019, 67 (9), pp 2581–2588
DOI: 10.1021/acs.jafc.9b00009

pH-Sensitive Chitosan–Sodium Phytate Core–Shell Hollow Beads and Nanocapsules for the Encapsulation of Active Ingredients
J. Agric. Food Chem., 2019, 67 (10), pp 2894–2905
DOI: 10.1021/acs.jafc.8b03919

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GFN2-xTB—An Accurate and Broadly Parametrized Self-Consistent Tight-Binding Quantum Chemical Method with Multipole Electrostatics and Density-Dependent Dispersion Contributions
Open Access Through ACS AuthorChoice
J. Chem. Theory Comput., 2019, 15 (3), pp 1652–1671
DOI: 10.1021/acs.jctc.8b01176

Systematic Coarse-Grained Lipid Force Fields with Semiexplicit Solvation via Virtual Sites
Open Access Through ACS AuthorChoice
J. Chem. Theory Comput., 2019, 15 (3), pp 2087–2100
DOI: 10.1021/acs.jctc.8b01033

Local Energy Decomposition of Open-Shell Molecular Systems in the Domain-Based Local Pair Natural Orbital Coupled Cluster Framework
Open Access Through ACS AuthorChoice
J. Chem. Theory Comput., 2019, 15 (3), pp 1616–1632
DOI: 10.1021/acs.jctc.8b01145

Evolutionary Approach to Constructing a Deep Feedforward Neural Network for Prediction of Electronic Coupling Elements in Molecular Materials
Open Access Through ACS AuthorChoice
J. Chem. Theory Comput., 2019, 15 (3), pp 1777–1784
DOI: 10.1021/acs.jctc.8b01285

Top-down Multiscale Approach To Simulate Peptide Self-Assembly from Monomers
J. Chem. Theory Comput., 2019, 15 (3), pp 1514–1522
DOI: 10.1021/acs.jctc.8b01025

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Clearance in Drug Design: Miniperspective
J. Med. Chem., 2019, 62 (5), pp 2245–2255
DOI: 10.1021/acs.jmedchem.8b01263

Discovery of a Natural-Product-Derived Preclinical Candidate for Once-Weekly Treatment of Type 2 Diabetes
J. Med. Chem., 2019, 62 (5), pp 2348–2361
DOI: 10.1021/acs.jmedchem.8b01491

Alkyl Sulfinates: Radical Precursors Enabling Drug Discovery: Miniperspective
J. Med. Chem., 2019, 62 (5), pp 2256–2264
DOI: 10.1021/acs.jmedchem.8b01303

Identification and Preclinical Pharmacology of ((1R,3S)-1-Amino-3-((S)-6-(2-methoxyphenethyl)-5,6,7,8-tetrahydronaphthalen-2-yl)cyclopentyl)methanol (BMS-986166): A Differentiated Sphingosine-1-phosphate Receptor 1 (S1P1) Modulator Advanced into Clinical Trials
J. Med. Chem., 2019, 62 (5), pp 2265–2285
DOI: 10.1021/acs.jmedchem.8b01695

Designing Dual Inhibitors of Anaplastic Lymphoma Kinase (ALK) and Bromodomain-4 (BRD4) by Tuning Kinase Selectivity
J. Med. Chem., 2019, 62 (5), pp 2618–2637
DOI: 10.1021/acs.jmedchem.8b01947

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Arabinoxyloglucan Oligosaccharides May Contribute to the Antiadhesive Properties of Porcine Urine after Cranberry Consumption
Open Access Through ACS Editors’ Choice
J. Nat. Prod., 2019, 82 (3), pp 589–605
DOI: 10.1021/acs.jnatprod.8b01043

Special Issue in Honor of Professor Rachel Mata
J. Nat. Prod., 2019, 82 (3), pp 423–424
DOI: 10.1021/acs.jnatprod.9b00067

Structural Revision of Macropodumine A and Structure of 2-Deoxymacropodumine A, Daphniphyllum Alkaloids with 11-Membered Macrolactone Rings
J. Nat. Prod., 2019, 82 (3), pp 427–430
DOI: 10.1021/acs.jnatprod.8b00232

Selective Depletion and Enrichment of Constituents in “Curcumin” and Other Curcuma longa Preparations
Open Access Through ACS AuthorChoice
J. Nat. Prod., 2019, 82 (3), pp 621–630
DOI: 10.1021/acs.jnatprod.9b00020

Prenylated Diresorcinols Inhibit Bacterial Quorum Sensing
Open Access Through ACS AuthorChoice
J. Nat. Prod., 2019, 82 (3), pp 550–558
DOI: 10.1021/acs.jnatprod.8b00925

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Unbiased Atomistic Insight into the Mechanisms and Solvent Role for Globular Protein Dimer Dissociation
Open Access Through ACS AuthorChoice
J. Phys. Chem. B, 2019, 123 (9), pp 1883–1895
DOI: 10.1021/acs.jpcb.8b10005

Single-Molecule FRET Kinetics of the Mn2+ Riboswitch: Evidence for Allosteric Mg2+ Control of “Induced-Fit” vs “Conformational Selection” Folding Pathways
J. Phys. Chem. B, 2019, 123 (9), pp 2005–2015
DOI: 10.1021/acs.jpcb.8b11841

Lipid Rafts: Buffers of Cell Membrane Physical Properties
J. Phys. Chem. B, 2019, 123 (9), pp 2050–2056
DOI: 10.1021/acs.jpcb.8b12126

How Water Permutes the Structural Organization and Microscopic Dynamics of Cholinium Glycinate Biocompatible Ionic Liquid
J. Phys. Chem. B, 2019, 123 (9), pp 2057–2069
DOI: 10.1021/acs.jpcb.8b10235

Raman Spectroscopic Study of the Effect of Aqueous Salt Solutions on the Inhibition of Carbon Dioxide Gas Hydrates
Open Access Through ACS AuthorChoice
J. Phys. Chem. B, 2019, 123 (10), pp 2354–2361
DOI: 10.1021/acs.jpcb.8b11040

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Interaction between Colloidal Quantum Dots and Halide Perovskites: Looking for Constructive Synergies
J. Phys. Chem. Lett., 2019, 10 (5), pp 1099–1108
DOI: 10.1021/acs.jpclett.8b03657

Thermally Stable Copper(II)-Doped Cesium Lead Halide Perovskite Quantum Dots with Strong Blue Emission
J. Phys. Chem. Lett., 2019, 10 (5), pp 943–952
DOI: 10.1021/acs.jpclett.9b00290

Contrasting Behavior of Antifreeze Proteins: Ice Growth Inhibitors and Ice Nucleation Promoters
J. Phys. Chem. Lett., 2019, 10 (5), pp 966–972
DOI: 10.1021/acs.jpclett.8b03719

Room-Temperature Phosphorescence from Metal-Free Organic Materials in Solution: Origin and Molecular Design
J. Phys. Chem. Lett., 2019, 10 (5), pp 1037–1042
DOI: 10.1021/acs.jpclett.9b00221

Potential Applications of Halide Double Perovskite Cs2AgInX6 (X = Cl, Br) in Flexible Optoelectronics: Unusual Effects of Uniaxial Strains
J. Phys. Chem. Lett., 2019, 10 (5), pp 1120–1125
DOI: 10.1021/acs.jpclett.9b00134

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Data-Independent Acquisition for the Orbitrap Q Exactive HF: A Tutorial
J. Proteome Res., 2019, 18 (3), pp 803–813
DOI: 10.1021/acs.jproteome.8b00845

Metabolic Signatures of Cystic Fibrosis Identified in Dried Blood Spots For Newborn Screening Without Carrier Identification
Open Access Through ACS Editors’ Choice
J. Proteome Res., 2019, 18 (3), pp 841–854
DOI: 10.1021/acs.jproteome.8b00351

Proteomic Atlas of the Human Brain in Alzheimer’s Disease
J. Proteome Res., 2019, 18 (3), pp 1380–1391
DOI: 10.1021/acs.jproteome.9b00004

Mapping the Ku Interactome Using Proximity-Dependent Biotin Identification in Human Cells
Open Access Through ACS AuthorChoice
J. Proteome Res., 2019, 18 (3), pp 1064–1077
DOI: 10.1021/acs.jproteome.8b00771

Suspension Trapping (S-Trap) Is Compatible with Typical Protein Extraction Buffers and Detergents for Bottom-Up Proteomics
J. Proteome Res., 2019, 18 (3), pp 1441–1445
DOI: 10.1021/acs.jproteome.8b00891