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Discover the Most-Read Organic/Inorganic Chemistry Articles of March 2019

There are lots of different ways to look at the reach of an article. You can look at citations, Altmetric Attention Scores, awards, and more. One way to consider the influence of an article is just by looking at how many people chose to read it. To that end, we’ve compiled lists of the five most-read chemistry articles that appeared in each ACS Publications journal in March 2019, including research, reviews, perspectives, and editorial pieces. These lists were not chosen by the journal’s editors and should not be taken as a “best of” list, but as another perspective on where the chemistry community allocated their attention.

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Read more of March’s most-read articles: Analytical | Applied | Biological | Materials Science & Engineering | Multidisciplinary | Organic/Inorganic | Physical


ACS Catalysis

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Catalysis by Metal Organic Frameworks: Perspective and Suggestions for Future Research
ACS Catal., 2019, 9 (3), pp 1779–1798
DOI: 10.1021/acscatal.8b04515

In Situ/Operando Techniques for Characterization of Single-Atom Catalysts
ACS Catal., 2019, 9 (3), pp 2521–2531
DOI: 10.1021/acscatal.8b04937

Development of Tandem Catalysts for CO2 Hydrogenation to Olefins
ACS Catal., 2019, 9 (3), pp 2639–2656
DOI: 10.1021/acscatal.8b05060

Electrochemical Energy Conversion on Intermetallic Compounds: A Review
ACS Catal., 2019, 9 (3), pp 2018–2062
DOI: 10.1021/acscatal.8b04566

PN3(P)-Pincer Complexes: Cooperative Catalysis and Beyond
ACS Catal., 2019, 9 (3), pp 1619–1629
DOI: 10.1021/acscatal.8b04495


ACS Combinatorial Science

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Bicyclic RGD Peptides with Exquisite Selectivity for the Integrin αvβ3 Receptor Using a “Random Design” Approach
Open Access Through ACS Editors’ Choice
ACS Comb. Sci., 2019, 21 (3), pp 198–206
DOI: 10.1021/acscombsci.8b00144

Targeting Protein–Protein Interactions of Tyrosine Phosphatases with Microarrayed Fragment Libraries Displayed on Phosphopeptide Substrate Scaffolds
Open Access Through ACS AuthorChoice
ACS Comb. Sci., 2019, 21 (3), pp 158–170
DOI: 10.1021/acscombsci.8b00122

Biginelli Reaction: Polymer Supported Catalytic Approaches
ACS Comb. Sci., 2019, 21 (3), pp 105–148
DOI: 10.1021/acscombsci.8b00120

Cellular-Based Selections Aid Yeast-Display Discovery of Genuine Cell-Binding Ligands: Targeting Oncology Vascular Biomarker CD276
ACS Comb. Sci., 2019, 21 (3), pp 207–222
DOI: 10.1021/acscombsci.8b00156

Development of a Method To Prioritize Protein–Ligand Pairs on Beads Using Protein Conjugated to a Near-IR Dye
ACS Comb. Sci., 2019, 21 (3), pp 223–228
DOI: 10.1021/acscombsci.8b00165


ACS Medicinal Chemistry Letters

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PROTAC Molecules for the Treatment of Autoimmune Disorders
ACS Med. Chem. Lett., 2019, 10 (3), pp 276–277
DOI: 10.1021/acsmedchemlett.9b00042

Harnessing Polypharmacology with Medicinal Chemistry
ACS Med. Chem. Lett., 2019, 10 (3), pp 273–275
DOI: 10.1021/acsmedchemlett.9b00039

Idea2Data: Toward a New Paradigm for Drug Discovery
ACS Med. Chem. Lett., 2019, 10 (3), pp 278–286
DOI: 10.1021/acsmedchemlett.8b00488

Identification and Preclinical Evaluation of the Bicyclic Pyrimidine γ-Secretase Modulator BMS-932481
Open Access Through ACS Editors’ Choice
ACS Med. Chem. Lett., 2019, 10 (3), pp 312–317
DOI: 10.1021/acsmedchemlett.8b00541

Atorvastatin (Lipitor) by MCR
Open Access Through ACS AuthorChoice
ACS Med. Chem. Lett., 2019, 10 (3), pp 389–392
DOI: 10.1021/acsmedchemlett.8b00579


Bioconjugate Chemistry

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Multivalency in Drug Delivery–When Is It Too Much of a Good Thing?
Bioconjugate Chem., 2019, 30 (3), pp 503–514
DOI: 10.1021/acs.bioconjchem.8b00804

Engineering Protein Delivery Depots for Cancer Immunotherapy
Bioconjugate Chem., 2019, 30 (3), pp 515–524
DOI: 10.1021/acs.bioconjchem.9b00061

Nanoparticle–Peptide–Drug Bioconjugates for Unassisted Defeat of Multidrug Resistance in a Model Cancer Cell Line
Bioconjugate Chem., 2019, 30 (3), pp 525–530
DOI: 10.1021/acs.bioconjchem.8b00755

Tetrazine—trans-Cyclooctene Chemistry Applied to Fabricate Self-Assembled Fluorescent and Radioactive Nanoparticles for in Vivo Dual Mode Imaging
Open Access Through ACS AuthorChoice
Bioconjugate Chem., 2019, 30 (3), pp 547–551
DOI: 10.1021/acs.bioconjchem.9b00038

Bench to Bedside: Albumin Binders for Improved Cancer Radioligand Therapies
Bioconjugate Chem., 2019, 30 (3), pp 487–502
DOI: 10.1021/acs.bioconjchem.8b00919


Inorganic Chemistry

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Induction of Enzyme-like Peroxidase Activity in an Iron Porphyrin Complex Using Second Sphere Interactions
Inorg. Chem., 2019, 58 (5), pp 2954–2964
DOI: 10.1021/acs.inorgchem.8b02707

Construction of Metallosupramolecular Coordination Complexes: From Lanthanide Helicates to Octahedral Cages Showing Single-Molecule Magnet Behavior
Inorg. Chem., 2019, 58 (5), pp 3167–3174
DOI: 10.1021/acs.inorgchem.8b03249

A ZnII-Based Metal–Organic Framework with a Rare tcj Topology as a Turn-On Fluorescent Sensor for Acetylacetone
Inorg. Chem., 2019, 58 (6), pp 3578–3581
DOI: 10.1021/acs.inorgchem.8b03316

Electronic Structures of an [Fe(NNR2)]+/0/– Redox Series: Ligand Noninnocence and Implications for Catalytic Nitrogen Fixation
Inorg. Chem., 2019, 58 (5), pp 3535–3549
DOI: 10.1021/acs.inorgchem.9b00133

Two-Dimensional Excitonic Metal–Organic Framework: Design, Synthesis, Regulation, and Properties
Inorg. Chem., 2019, 58 (5), pp 3145–3155
DOI: 10.1021/acs.inorgchem.8b03210


Journal of Medicinal Chemistry

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Clearance in Drug Design: Miniperspective
J. Med. Chem., 2019, 62 (5), pp 2245–2255
DOI: 10.1021/acs.jmedchem.8b01263

Discovery of a Natural-Product-Derived Preclinical Candidate for Once-Weekly Treatment of Type 2 Diabetes
J. Med. Chem., 2019, 62 (5), pp 2348–2361
DOI: 10.1021/acs.jmedchem.8b01491

Alkyl Sulfinates: Radical Precursors Enabling Drug Discovery: Miniperspective
J. Med. Chem., 2019, 62 (5), pp 2256–2264
DOI: 10.1021/acs.jmedchem.8b01303

Identification and Preclinical Pharmacology of ((1R,3S)-1-Amino-3-((S)-6-(2-methoxyphenethyl)-5,6,7,8-tetrahydronaphthalen-2-yl)cyclopentyl)methanol (BMS-986166): A Differentiated Sphingosine-1-phosphate Receptor 1 (S1P1) Modulator Advanced into Clinical Trials
J. Med. Chem., 2019, 62 (5), pp 2265–2285
DOI: 10.1021/acs.jmedchem.8b01695

Designing Dual Inhibitors of Anaplastic Lymphoma Kinase (ALK) and Bromodomain-4 (BRD4) by Tuning Kinase Selectivity
J. Med. Chem., 2019, 62 (5), pp 2618–2637
DOI: 10.1021/acs.jmedchem.8b01947


Journal of Natural Products

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Arabinoxyloglucan Oligosaccharides May Contribute to the Antiadhesive Properties of Porcine Urine after Cranberry Consumption
Open Access Through ACS Editors’ Choice
J. Nat. Prod., 2019, 82 (3), pp 589–605
DOI: 10.1021/acs.jnatprod.8b01043

Special Issue in Honor of Professor Rachel Mata
J. Nat. Prod., 2019, 82 (3), pp 423–424
DOI: 10.1021/acs.jnatprod.9b00067

Structural Revision of Macropodumine A and Structure of 2-Deoxymacropodumine A, Daphniphyllum Alkaloids with 11-Membered Macrolactone Rings
J. Nat. Prod., 2019, 82 (3), pp 427–430
DOI: 10.1021/acs.jnatprod.8b00232

Selective Depletion and Enrichment of Constituents in “Curcumin” and Other Curcuma longa Preparations
Open Access Through ACS AuthorChoice
J. Nat. Prod., 2019, 82 (3), pp 621–630
DOI: 10.1021/acs.jnatprod.9b00020

Prenylated Diresorcinols Inhibit Bacterial Quorum Sensing
Open Access Through ACS AuthorChoice
J. Nat. Prod., 2019, 82 (3), pp 550–558
DOI: 10.1021/acs.jnatprod.8b00925


The Journal of Organic Chemistry

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Photoredox Alkenylation of Carboxylic Acids and Peptides: Synthesis of Covalent Enzyme Inhibitors
Open Access Through ACS Editors’ Choice
J. Org. Chem., 2019, 84 (5), pp 2379–2392
DOI: 10.1021/acs.joc.8b02759

Photoredox-Catalyzed Intermolecular Radical Arylthiocyanation/Arylselenocyanation of Alkenes: Access to Aryl-Substituted Alkylthiocyanates/Alkylselenocyanates
J. Org. Chem., 2019, 84 (6), pp 3025–3035
DOI: 10.1021/acs.joc.8b03155

Ligand-Free Copper(I)-Catalyzed Benzylic Acyloxylation of 2-Alkylpyridines under Aerobic Conditions
J. Org. Chem., 2019, 84 (6), pp 3074–3082
DOI: 10.1021/acs.joc.8b02794

Synthetic Approach to Readily Accessible Benzofuran-Fused Borondipyrromethenes as Red-Emitting Laser Dyes
J. Org. Chem., 2019, 84 (5), pp 2523–2541
DOI: 10.1021/acs.joc.8b02933

Metal-Free Amidation Reactions of Terminal Alkynes with Benzenesulfonamide
J. Org. Chem., 2019, 84 (6), pp 3176–3183
DOI: 10.1021/acs.joc.8b03065


Molecular Pharmaceutics

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Doxorubicin and Anti-PD-L1 Antibody Conjugated Gold Nanoparticles for Colorectal Cancer Photochemotherapy
Mol. Pharmaceutics, 2019, 16 (3), pp 1184–1199
DOI: 10.1021/acs.molpharmaceut.8b01157

Insights into the Dissolution Mechanism of Ritonavir–Copovidone Amorphous Solid Dispersions: Importance of Congruent Release for Enhanced Performance
Mol. Pharmaceutics, 2019, 16 (3), pp 1327–1339
DOI: 10.1021/acs.molpharmaceut.8b01261

Delivery of Doxorubicin from Hyaluronic Acid-Modified Glutathione-Responsive Ferrocene Micelles for Combination Cancer Therapy
Mol. Pharmaceutics, 2019, 16 (3), pp 987–994
DOI: 10.1021/acs.molpharmaceut.8b00862

Polymer Nanocoating of Amorphous Drugs for Improving Stability, Dissolution, Powder Flow, and Tabletability: The Case of Chitosan-Coated Indomethacin
Open Access Through ACS AuthorChoice
Mol. Pharmaceutics, 2019, 16 (3), pp 1305–1311
DOI: 10.1021/acs.molpharmaceut.8b01237

Lipolysis-Permeation Setup for Simultaneous Study of Digestion and Absorption in Vitro
Open Access Through ACS AuthorChoice
Mol. Pharmaceutics, 2019, 16 (3), pp 921–930
DOI: 10.1021/acs.molpharmaceut.8b00811


Organic Letters

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A Nine-Step Formal Synthesis of (±)-Morphine
Org. Lett., 2019, 21 (5), pp 1347–1349
DOI: 10.1021/acs.orglett.9b00044

Direct Access to Acyl Fluorides from Carboxylic Acids Using a Phosphine/Fluoride Deoxyfluorination Reagent System
Org. Lett., 2019, 21 (6), pp 1659–1663
DOI: 10.1021/acs.orglett.9b00197

Photoinduced Transition-Metal-Free Cross-Coupling of Aryl Halides with H-Phosphonates
Org. Lett., 2019, 21 (5), pp 1301–1305
DOI: 10.1021/acs.orglett.8b04081

Room Temperature Deoxyfluorination of Benzaldehydes and α-Ketoesters with Sulfuryl Fluoride and Tetramethylammonium Fluoride
Org. Lett., 2019, 21 (5), pp 1350–1353
DOI: 10.1021/acs.orglett.9b00054

Sulfonamides Are an Overlooked Class of Electron Donors in Luminogenic Luciferins and Fluorescent Dyes
Org. Lett., 2019, 21 (6), pp 1641–1644
DOI: 10.1021/acs.orglett.9b00173


Organic Process Research & Development

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Some Items of Interest to Process R&D Chemists and Engineers
Org. Process Res. Dev., 2019, 23 (3), pp 289–301
DOI: 10.1021/acs.oprd.9b00092

Efficient Electrocatalytic Reduction of Furfural to Furfuryl Alcohol in a Microchannel Flow Reactor
Open Access Through ACS AuthorChoice
Org. Process Res. Dev., 2019, 23 (3), pp 403–408
DOI: 10.1021/acs.oprd.8b00428

Effects of Scale, Equipment, and Operation on Agglomeration during a Reactive Crystallization
Org. Process Res. Dev., 2019, 23 (3), pp 302–308
DOI: 10.1021/acs.oprd.8b00227

Rapid On-Demand Synthesis of Lomustine under Continuous Flow Conditions
Org. Process Res. Dev., 2019, 23 (3), pp 334–341
DOI: 10.1021/acs.oprd.8b00387

Early Process Development of an Irreversible Epidermal Growth Factor Receptor (EGFR) T790 M Inhibitor
Org. Process Res. Dev., 2019, 23 (3), pp 382–388
DOI: 10.1021/acs.oprd.8b00437


Organometallics

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Organometallic Electrochemistry: Redox Catalysis Going the Smart Way
Organometallics, 2019, 38 (6), pp 1181–1185
DOI: 10.1021/acs.organomet.9b00111

Oxidative Addition of Dihydrogen, Boron Compounds, and Aryl Halides to a Cobalt(I) Cation Supported by a Strong-Field Pincer Ligand
Organometallics, 2019, 38 (5), pp 1081–1090
DOI: 10.1021/acs.organomet.8b00870

Selective Ethylene Oligomerization
Organometallics, 2019, 38 (5), pp 997–1010
DOI: 10.1021/acs.organomet.8b00799

Reversible C–N Bond Formation in the Zirconium-Catalyzed Intermolecular Hydroamination of 2-Vinylpyridine
Organometallics, 2019, 38 (5), pp 1011–1016
DOI: 10.1021/acs.organomet.8b00904

High-Performance Neutral Phosphine-Sulfonate Nickel(II) Catalysts for Efficient Ethylene Polymerization and Copolymerization with Polar Monomers
Organometallics, 2019, 38 (5), pp 1118–1126
DOI: 10.1021/acs.organomet.8b00916

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