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Small Molecule Could Help Modulate the Microbiome 

Small Molecule Could Help Modulate the Microbiome 

Hundreds of microbial species inhabit the human gut and support digestion, immunity, and other functions. Changes in their populations have been linked to diabetes, asthma, cancers and many other diseases. But so far, the complexity of microbial communities has made them impractical targets for controlling disease. Now, researchers report that a small molecule can block a type of common gut bacteria from consuming starch, which slows their growth. The results could offer a way to manipulate the bacteria’s proportions in the gut microbiome—a strategy that could eventually help researchers understand the microbiome’s role in health.

So far, researchers have tried to tweak human and animal microbiomes with nutritional supplements, probiotic cocktails, or fecal transplants laden with microbes from other individuals. But small-molecule-based approaches have rarely been attempted: Common antimicrobial drugs wipe out a broad range of species, so they can’t be used to precisely edit a microbial community.

Organic chemist Daniel C. Whitehead and microbiologist Kristi Whitehead of Clemson University and their colleagues teamed up to find a more subtle approach that would manipulate selected members of the gut microbial community. The researchers homed in on Bacteroides, which represent more than half of the human gut microbiome and consume dietary starch and complex sugars. At least one study has shown that, compared to healthy individuals, patients with type 1 diabetes have a higher proportion of certain Bacteroides species in their gut microbiome before the onset of disease symptoms.

In the new study, the team looked at two species of Bacteroides whose starch utilization pathways had been particularly well characterized. With these strains, they tested three small molecules that inhibit human starch-digesting enzymes for their ability to act on bacterial enzymes. In laboratory cultures containing a variety of sugars, one of the molecules, acarbose, prevented Bacteroides species from consuming potato starch and fungal pullulan, a starch used as a common food additive. Acarbose did not kill the microbes or block them from digesting other sugars such as glucose.

On other sugar sources, the molecule had little impact on Bacteroides growth. But when the starch-derived polysaccharide pullulan or potato starch were the only foods provided, acarbose shut down the growth of Bacteroides. It did not affect Ruminococcus, another common gut inhabitant, even though this species also metabolizes starch.

In these initial experiments, the researchers tested the bacteria in individual, lab-grown cultures. Therefore, it remains to be seen whether the human gut microbiome will respond in the same way. “But the results show that the system is targetable, which itself is quite significant,” says organic chemist Herman O. Sintim of Purdue University, who was not involved with the study.

“In the gut, it’s unlikely that only starches are going to be present,” says Kristi Whitehead, but acarbose would give Bacteroides fewer carbohydrates to choose from on the bacterial buffet. “In that highly competitive environment, that should reduce their growth.”

The researchers plan to extend their experiments to mixed bacterial cultures and animal models. “This work is really a proof of concept that a small molecule can arrest the starch utilization system,” says Daniel Whitehead.

So far, it’s not clear whether changes to the gut microbiome cause illness or are merely correlated to disease conditions. For instance, when Bacteroides flourishes before the onset of type 1 diabetes, the bacterial bloom could result from underlying metabolic changes or cause them. Blocking a metabolic pathway such as starch digestion might help prevent that early proliferation, and could serve as “a tool to actually answer that question,” Sintim says.

This article is reproduced with permission from C&EN (© American Chemical Society). The article was first published on May 16, 2018.

Cane Toad Microbiome Transforms its Toxins

In 1935, about 100 cane toads (Rhinella marina) were released in sugar cane fields in northeastern Australia to control beetles eating the sugar cane. Today, an estimated 1.5 billion toads have spread thousands of miles across the continent, killing native species, to the brink of extinction in some cases. When predators munch on a cane toad, milky secretions full of a family of steroidal toxins called bufagenins ooze from the parotoid glands on the toad’s shoulders.

Microbes in the shoulder glands of cane toads hydroxylate marinobufagenin at the highlighted location, producing 11α-hydroxymarinobufagenin.

Robert J. Capon of the University of Queensland previously found that Gram-negative bacteria isolated from these glands could completely degrade bufagenins. The researchers wondered if other bacteria from the cane toad microbiome could also alter bufagenins, producing some of the types observed in cane toad eggs and tadpoles.

The researchers isolated three different strains of Gram-positive Bacillus species from the parotoid glands of two toads collected on campus. They fed the bacteria one of four different bufagenins produced by adult toads. After seven days, the researchers isolated compounds in the culture and found hydroxylated bufagenins. These derivatives are also found on cane toad eggs and tadpoles. In nature these modified toxins originate with the mother and are thought be modified in ways that protect the tadpoles and eggs in aquatic environments.

Capon speculates that a toad’s microbiome could hold clues to controlling the toad population. Inoculating the toads with other microbes that might change the bufagenin modifications as the adult females pass toxins to their eggs could be a helpful strategy, for example. “Would that reduce the viability of the eggs?” he wonders.

#ACSMicrobiome Webinar Part 3: The Microbiome in Health and Disease

Our bodies are filled with microorganisms, and scientists are just beginning to learn how they interact with each other and with our bodies.

On August 16, 2016, ACS Infectious Diseases and Journal of Proteome Research presented The Microbiome in Health and Disease, final installment in the three-part #ACSmicrobiome Webinar Series, which examined what scientists are doing to understand how the microbiome affects human health and disease. The webinar featured Dr. Emily Balskus, Morris Kahn Associate Professor of Chemistry and Chemical Biology at Harvard University, and Dr. Gary Siuzdak, Professor of Chemistry, Molecular and Computational Biology at The Scripps Research Institute and Senior Director of the Scripps Center for Metabolomics.

The Microbiome of the Human Gut

Microbial communities can be found everywhere on Earth, and the human body is no exception, Balskus says. There are microbes living on and inside of us. “If you count up the number of microbial cells associated with a person, you find we are just as much microbial as we are human.”

The colon is home to the most microbes found in the human body, and is one of the densest known microbial habitats on the planet, Balskus says. But while we all have microbiomes in our guts, the types of microbes inside us vary greatly. It is known that these organisms can influence energy balance and nutrition, help train the immune system, and provide protection from pathogens such as the bacteria Clostridium difficile (C. diff.). However, science has yet to determine exactly how they affect our bodies, and only 2% of the plasma metabolites influenced by gut microbes have been identified, Balskus says.

A great example of an identified compound and its effect on the body is trimethylamine (TMA), elevated levels of which are associated with trimethylaminuria, an inherited metabolic disorder known commonly as fish malodor syndrome. It is caused by a gene encoding mutation that causes enzymes to be unable to convert all of the TMA that the gut produces, Balskus says. Because there are no targeted treatments for the disease, patients will alter their own microbiomes with antibiotics or changes in their diets.

Balskus says work is being done to develop small molecules that can be manipulated, and targeted small molecule inhibitors could lead to more selective ways to study the microbiome. “We need better tools and approaches that will allow us to study chemistry directly in the microbial communities where it is taking place.”

Applying Technology to Link the Microbiome to Colon Cancer

One tool researchers are using to learn more about the human microbiome is XCMS, a metabolomic platform that allows for mass spectrometry and analysis. In his presentation, Siuzdak described how his team has used XCMS in examining colon cancer and how the microbiome can affect the disease’s progression.

Patients with tumors found on the cecum side, or right side, of the colon live about half as long as those with tumors on sigmoid side, or left side. Siuzdak and his team used mass spectrometry-based metabolomic analysis to examine tumor samples, working with Dr. David Elder at Karolinska Institutet, Dr. Cynthia Spears at Johns Hopkins University, and Dr. Laura Geotz at University of California, San Diego. Using XCMS, Siuzdak’s team was able to align the different liquid chromatology-mass spectrometry analyses of the metabolites in the different samples into a more coherent map. Being able to visualize and pull out the most interesting data was a huge help in the work, he explained.

They found that the cecum side tumors tend to have biofilm, or microorganisms that attach to each other, on them. Siuzdak said it is possible that the biofilms may be growing by feeding on polyamines, which are typically produced by tumors. The team also found that biofilms are penetrating the cells, which can stimulate cellular proliferation, which Siuzdak says indicates a “symbiotic relationship between the biofilm growth and the tumor growth.” While they still don’t know why the patients with cecum side tumors live for shorter amounts of time, they are a step closer to that discovery, and using XCMS to analyze the metabolomic data helped them get this far.

Want to learn more about the technology scientists are using to study microbiomes? You can watch a recording of the full webinar complete with Dr. Balskus and Dr. Siuzdak’s slides through August 15, 2017, just register here.

#ACSmicrobiome Webinar Part 2: Microbiome Technologies

The scientific community is learning more about microorganisms and how they interact with each other in microbiomes. Technology is making their discoveries possible and more is needed to advance their research even further.

On August 11, 2016, ACS Nano and Analytical Chemistry presented Microbiome Technologies, the second in the three-part #ACSmicrobiome Webinar Series. The webinar focused on the current technology researchers are using to study the microbiome and the technology they will need moving forward. It featured Dr. Paul S. Weiss, Editor-in-Chief of ACS Nano; Distinguished Professor of Chemistry & Biochemistry, Distinguished Professor of Materials Science & Engineering, California NanoSystems Institute at the University of California, Los Angeles, and Dr. Pieter Dorrestein, Professor at the University of California, San Diego; Director of the Collaborative Mass Spectrometry Innovation Center; and a Co-Director of the Institute for Metabolomics Medicine in the Skaggs School of Pharmacy & Pharmaceutical Sciences, and Department of Pharmacology.

Technology is Essential to Understanding Microbiomes

Microbiomes are found all over – in and on human bodies, in the ocean, the atmosphere, and the soil. Research on microbiomes touch on many different disciplines, says Weiss, which can create gaps in the understanding of microbiomes from one area of research to another. To address this, “tremendous technologies need to be developed,” he said.

“One of the advantages of the field nanoscience and nanotechnology is that we’ve taught each other how to communicate across fields, and maybe even more than the technology has required,” Weiss said.

To learn more about microbiomes, scientists need the tools to observe, manipulate and measure on the nano level. This will lead to the development of specialized technology. Researchers studying the microbiomes of the ocean, which are strongly connected with local environments, are being aided by new miniaturized, ruggedized technology, Weiss says. The development of new tools, such as these, that manipulate the microbiome will lead to a better understanding of how these systems work.

Digitally Mapping the Human Microbiome

The National Institutes of Health Human Microbiome Project has found that the human body consists of 20,000 human genes and 2 million to 20 million microbial genes. These findings have redefined what it is to be human, Dorrestein says. Microbes are involved in the metabolism of foods and changing immune chemistries. They can determine your weight, or how attractive you are to mosquitoes. Microbes are “the ignored organ” of the human body, he says.

The scientific community has been able to determine what microbes are inside the body, and now the research is shifting to what they are doing to the body and how to take control of that, Dorrestein says.

Dorrestein has developed a three-dimensional (3D) mapping tool, called ili, with Dr. Theodore Alexandrov of the European Molecular Biology Laboratory. The tool allows you to map data, such as where samples are taken on a person’s body, on to a 3D model. This allows researchers to visualize mass spectrometry data, and from there, observe and analyze the data.
To analyze that data, a metabolomics analysis and knowledge capture platform, called Global Natural Products Social Molecular Networking (GNPS) was created. Dorrestein said it launched in August with roughly 13,000 users from 111 countries. The platform allows researchers to upload, store and analyze data, with a predictive computing element, as well. GNPS allows researchers to share and pool their data, which will hopefully allow researchers to crowdsource analysis.

Want to learn more about the technology scientists are using to study microbiomes? You can watch a recording of the full webinar complete with Dr. Weiss and Dr. Dorrestein’s slides through August 10, 2017, just register here.

#ACSmicrobiome Webinar Part 1: The Microbiome and the Environment

Advances in technology and research methods have in recent years allowed scientists to more effectively study Earth’s oldest life forms – microorganisms. They’ve discovered almost all microorganisms exist not alone, but in communities commonly known as “the microbiome,” and that these communities interact with their environments in a variety of ways.

On July 26, Environmental Science & Technology and Environmental Science & Technology Letters presented The Microbiome and the Environment, a webinar focused on the microbiome of the urban water cycle. In this first of the three-part #ACSmicrobiome webinar series, Dr. Lutgarde Raskin, Altarum/ERIM Russell O’Neal Professor of Environmental Engineering at the University of Michigan, and Dr. Tong Zhang, Professor in the Environmental Biotechnology Laboratory in the Department of Civil Engineering at The University of Hong Kong discussed what their research has uncovered about the critical role of the microbiome in the urban water cycle.

The Microbiome of Drinking Water

Before it reaches our taps, drinking water goes through a multi-step treatment process that includes primary disinfection through exposure to ozone and biofiltration, and secondary disinfection through exposure to chloramine, Raskin says. But the water we drink still ends up with between 106 and 108 bacterial cells per liter.

It’s impossible to remove all mycobacteria from drinking water, so water treatment efforts focus on removing pathogenic microbes – the microorganisms that can cause disease in humans, particularly people with compromised immune systems, Raskin says. Mycobacteria avium and Mycobacteria abscessus are two environmental, or naturally occurring, mycobacteria whose levels need to be monitored in public water systems, as they can cause disease, and have shown some resistance to disinfectants.

Raskin’s research team studied the tap water from a group of houses in Ann Arbor, Michigan. Seven of the houses were close to the water treatment plant, and eight were farther away from the facility. The water coming out of the taps close to the plant had less exposure to chloramine in the city’s water distribution system, as it had a shorter distance to travel through that system. The water that traveled farther through the system before reaching the tap had greater exposure to chloramine. They found bacterial and mycobacterial concentrations were higher in samples taken farther away from the water treatment plant, Raskin says.

“I think it’s critically important to study all kinds of microbial phenomena within the context of the complex drinking water microbiome, and that we not just want to do this in the lab, but want to go into the field, studying full-scale systems, because there is complexity that we cannot mimic in the lab,” she says.

The Microbiome of Wastewater Treatment Plants

Another element of the urban water cycle is wastewater treatment plants, which have their own unique microbiomes. These facilities can be hotspots for antibiotic resistance genes because their microbiomes are home to thousands of species, have a high biomass density, and bacteria input from the waste of thousands of people, Zhang says. Wastewater treatment facilities must ensure these ARGs are removed from the wastewater to prevent their spread.

Wastewater treatment plants must monitor levels of bacteria associated with bulking, which is activated sludge with poor settling and compaction characteristics, and foaming, Zhang says. Both bulking and foaming can lead to overflow and hinder a plant’s operations. He praised the advances made in metagenomics, which provide technicians with information about the bacterial makeup of the microbiome in a quick, quantitative, and qualitative way.

Large-scale DNA sequencing and metagenomics are important tools in studying the bacterial profiles of the microbiome at the genus level, Zhang says. And the technological advancements must continue. He calls for specific, customized databases that would allow for better analysis of the bacterial profiles of wastewater treatment plants. Among Zhang’s other predictions for new developments is that third-generation genomic sequencing will allow for longer sequences, which will make analysis more accurate.

Want to learn more about the microbiome of the urban water cycle? You can watch a recording of the full webinar complete with Dr. Raskin and Dr. Zhang’s slides through July 25, 2017, just register here.

 

Take the ACS Infectious Diseases #ACSmicrobiome Quiz

The microbiome is a hot topic in the popular media and in labs around the world. Chemists, biochemists, and other scientists are continually making new discoveries about the microbiome and how it affects health and the environment.

To highlight the latest chemistry, biochemistry, and chemical biology research on how the microbiome relates to infectious diseases, ACS Infectious Diseases is publishing a Special Issue titled The Microbiome with Guest Editor Emily Balskus later this year. If you’re doing research in these areas, please visit The Microbiome Special Issue call for papers to learn more and submit your manuscript.

Take The Microbiome Quiz!


Take the Microbiome Quiz
1. Which area on the surface of the human body has been found to host the most diverse collection of microbes?
Behind the ear

On the forearm

In the bellybutton

In-between the toes

It’s no secret that the human body is made up largely of microbes – over 100 trillion by some estimates. By what ratio do microbes outnumber human cells in our bodies?
10 to 1

100 to 1

1,000 to 1

10,000 to 1

The human digestive tract is home to a majority of the microbes that make up the human microbiome. Roughly what percent of an individual’s microbiome can be found in their digestive tract?

55%

70%

90%

99%

A recent Dutch study concluded that individuals who engage in intimate kissing have a more similar oral microbiota composition compared with unrelated individuals. On average, how many bacteria did they find were transferred in a 10 second intimate kiss?
10 million

80 million

120 million

200 million

Which winner of the Nobel Prize in Medicine purposely ingested Heliobacter pylori in order to prove that stomach ulcers are caused by bacteria, not stress?
Linda Buck

Harold zur Hausen

Barry Marshall

Shinya Yamanaka

Which ACS journal is currently accepting papers for an upcoming Special Issue on the Microbiome?
ACS Infectious Diseases

Journal of Proteome Research

ACS Medicinal Chemistry

Biochemistry

Think You Know the Human Microbiome?
ACS Infectious Diseases invites you to take this short, six question quiz to test your knowledge of some of the more interesting developments in research surrounding the human microbiome over the past 15 years. Go with your gut and see if you can get all six questions right! Take our quiz and find out!


Whether you’re researching the microbiome or not, it’s hard at work having an effect on your body and your health. Take this short ACS Infectious Diseases quiz and test your knowledge on the human microbiome then watch The Microbiome in Health and Disease, a webinar sponsored by ACS Infectious Diseases and Journal of Proteome Research to learn more.

#ACSmicrobiome Webinar Series Examines How Chemists Are Studying the Microbiome

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Microorganisms are Earth’s oldest life forms and have come to inhabit virtually every location on the planet. Recent advances in technology have enabled researchers to dissect how microorganisms interact with their surroundings. These investigations reveal that microorganisms exist in complex communities commonly referred to as “the microbiome.”

These microbial communities have been found to be integral to many processes, including human and animal health, and environmental nutrient cycling. In light of our growing appreciation of the importance of the microbiome, ACS Publications began a three-part webinar series on July 26 exploring how chemists are studying this important topic.

Part 1: The Microbiome and the Environment

In this first webinar in the series, The Microbiome and the Environment, sponsored by Environmental Science & Technology and Environmental Science & Technology Letters, Dr. Ariel Grostern, Managing Editor of Environmental Science & Technology, Environmental Science & Technology Letters, and Journal of Agriculture and Food Chemistry, led Dr. Lutgarde Raskin, Altarum/ERIM Russell O’Neal Professor of Environmental Engineering at the University of Michigan, and Dr. Tong Zhang, Professor in the Environmental Biotechnology Laboratory in the Department of Civil Engineering at The University of Hong Kong, in a discussion of the role microorganisms play in the urban water cycle. Dr. Raskin and Dr. Zhang explained how molecular biology is providing insights into the complex microbial communities of wastewater treatment plants and the spread of antibiotic-resistant genes.

If you missed the live webinar, you can watch the recording complete with Dr. Grostern, Dr. Raskin, and Dr. Zhang’s slides any time. Just register here anytime.

Part 2: Microbiome Technologies

This second webinar in the series, Microbiome Technologies, is sponsored by ACS Nano and Analytical Chemistry and will address the role of the microbiome as it pertains to technology. The extraordinary measurement and manipulation requirements of studying the microbiome open up great opportunities for chemists, nanoscientists, and other researchers. These broad needs include the ability to eavesdrop on chemical communications, conduct massive multimodal data science, and develop synthetic biology- and mass spectrometry-based tools to manipulate organisms and populations. This webinar will provide an overview of the function of these technologies and discuss challenges and areas for investigation in these technologies.

Date: Thursday, Aug. 11

Time: 11:00 a.m. EDT, 10:00 a.m. CDT, 8:00 a.m. PDT

Key Learning Objectives:

Moderator: Laura Fernandez, Managing Editor of ACS Nano and Nano Letters

Speakers:

Register today!

Part 3: The Microbiome in Health and Disease

This third webinar in the series, The Microbiome in Health and Disease, is sponsored by ACS Infectious Diseases and Journal of Proteome Research and will address the microbiome’s critical role in maintaining health and preventing disease. The gut’s microbiome plays an integral role not only in maintaining metabolism but also in providing a barrier against infectious disease. This webinar will offer an overview of the microbiome’s function in these aspects of human health and discuss in detail challenges to investigating the subject and various approaches to overcoming them. Attendees will learn about opportunities for chemists and chemical biologists in this research area.

Date: Tuesday, Aug. 16

Time: 11:00 a.m. EDT, 10:00 a.m. CDT, 8:00 a.m. PDT

Key Learning Objectives:

Moderator: Kristen Kindrachuk, Managing Editor of ACS Infectious Diseases, ACS Medicinal Chemistry Letters and Journal of Medicinal Chemistry

Speakers:

Register today!

The Microbiome: An ACS Infectious Diseases Special Issue

Dr. Balskus is also the Guest Editor for an upcoming special issue of ACS Infectious Diseases titled The Microbiome. The issue is scheduled for publication in 2017 and the journal is accepting manuscripts until Oct. 1, 2016.

Submit your research on the microbiome today!

Tweet about these webinars, the ACS Infectious Diseases special issue The Microbiome, and the topic in general using the hashtag #ACSmicrobiome.

 

Call for Papers: ACS Earth and Space Chemistry Special Issue: Chemical Interactions in the Plant-Atmosphere-Soil System

ACS Earth and Space Chemistry welcomes contributions for an upcoming special issue devoted to “Chemical Interactions in the Plant-Atmosphere-Soil System.” The scope of this issue covers the plant-atmosphere-soil system with its associated microbiomes, which is best viewed as an integrated system, where phenotypic expression at the systems level is governed by chemical interactions at the subcellular level, i.e., interactions within plant or microbial cells, the intercellular level, i.e., cellular interactions within plants cells, between plants and microbes or between microbes, and the extracellular level, i.e., atmospheric interactions or interactions involving soil minerals or soil organic matter. Our ability to understand, predict, and ultimately control the function of plant-atmosphere-soil systems and their responses to environmental variables requires unraveling this complex network of chemical interactions.

Submission of both original research and review-type papers are encouraged. Interested researchers should plan to commit to a submission timeline on or before November 1, 2020, so that the journal can ensure timely publication of this special issue.

The Guest Editors welcome any pre-inquiries on manuscript concepts should questions arise about relevance against scope.

Submit Your Manuscript Today

Browse the Most-Read Articles of May 2020

There are lots of different ways to look at the reach of an article. You can look at citations, Altmetric Attention Scores, awards, and more. One way to consider the influence of an article is just by looking at how many people chose to read it. To that end, we’ve compiled lists of the five most-read chemistry articles from each ACS Publications journal in May 2020, including research, reviews, perspectives, and editorial pieces. These lists were not chosen by the journal’s editors and should not be taken as a “best of” list, but as another perspective on where the chemistry community allocated their attention.

Click on your favorite journal below to see their most-read articles of the month.

Sign up to get this list in your inbox every month.


Accounts of Chemical Research

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Intramolecularly Cross-Linked Polymers: From Structure to Function with Applications as Artificial Antibodies and Artificial Enzymes
Open Access through ACS Editors’ Choice
DOI: 10.1021/acs.accounts.0c00178

CuH-Catalyzed Olefin Functionalization: From Hydroamination to Carbonyl Addition
DOI: 10.1021/acs.accounts.0c00164

Charge Transport in Zirconium-Based Metal–Organic Frameworks
DOI: 10.1021/acs.accounts.0c00106

Narrowing the Band Gap: The Key to High-Performance Organic Photovoltaics
DOI: 10.1021/acs.accounts.0c00157

Key References: A New Feature of Accounts
DOI: 10.1021/acs.accounts.0c00326



ACS Applied Bio Materials

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Nucleic Acids: Chemistry, Nanotechnology, and Bioapplications Forum in Honor of Professor Weihong Tan on His 60th Birthday
This article is part of the Nucleic Acids: Chemistry, Nanotechnology, and Bioapplications special issue.
DOI: 10.1021/acsabm.0c00468

Correlating Digestion-Driven Self-Assembly in Milk and Infant Formulas with Changes in Lipid Composition
Open Access through ACS AuthorChoice
DOI: 10.1021/acsabm.0c00131

Hypocrellin-Based Multifunctional Phototheranostic Agent for NIR-Triggered Targeted Chemo/Photodynamic/Photothermal Synergistic Therapy against Glioblastoma
Open Access through ACS Editors’ Choice
DOI: 10.1021/acsabm.0c00386

Decoupling the Amplitude and Wavelength of Anisotropic Topography and the Influence on Osteogenic Differentiation of Mesenchymal Stem Cells Using a High-Throughput Screening Approach
Open Access through ACS AuthorChoice
DOI: 10.1021/acsabm.0c00330

Ultrasmall Gold Nanoparticles Cellular Uptake: Influence of Transient Bionano Interactions
DOI: 10.1021/acsabm.0c00379



ACS Applied Electronic Materials

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Manganese Doping Stabilizes Perovskite Light-Emitting Diodes by Reducing Ion Migration
Open Access through ACS AuthorChoice
DOI: 10.1021/acsaelm.0c00125

Memristive Device Characteristics Engineering by Controlling the Crystallinity of Switching Layer Materials
DOI: 10.1021/acsaelm.0c00148

Jelly-Inspired Construction of the Three-Dimensional Interconnected BN Network for Lightweight, Thermally Conductive, and Electrically Insulating Rubber Composites
DOI: 10.1021/acsaelm.0c00227

Depolarization as Driving Force in Antiferroelectric Hafnia and Ferroelectric Wake-up
DOI: 10.1021/acsaelm.0c00184

Ultrathin Ag Transparent Conducting Electrode Structure for Next-Generation Optoelectronic Applications
DOI: 10.1021/acsaelm.0c00156



ACS Applied Energy Materials

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Operando Transmission Electron Microscopy Study of All-Solid-State Battery Interface: Redistribution of Lithium among Interconnected Particles
Open Access through ACS AuthorChoice
DOI: 10.1021/acsaem.0c00543

Rapid Scalable Processing of Tin Oxide Transport Layers for Perovskite Solar Cells
Open Access through ACS AuthorChoice
DOI: 10.1021/acsaem.0c00525

Capacity Improvement by Nitrogen Doping to Lithium-Rich Cathode Materials with Stabilization Effect of Oxide Ions Redox
DOI: 10.1021/acsaem.0c00564

Syngas Evolution from CO2 Electroreduction by Porous Au Nanostructures
DOI: 10.1021/acsaem.0c00301

Exploring Lewis-Base Effects to Improve the Efficiency of [Co(bpy)3]2+/3+-Mediated Dye-Sensitized Solar Cells
Open Access through ACS AuthorChoice
DOI: 10.1021/acsaem.0c00665



ACS Applied Materials & Interfaces

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Bioinspired “Skin” with Cooperative Thermo-Optical Effect for Daytime Radiative Cooling
DOI: 10.1021/acsami.0c03897

Freezing-Tolerant, Highly Sensitive Strain and Pressure Sensors Assembled from Ionic Conductive Hydrogels with Dynamic Cross-Links
DOI: 10.1021/acsami.0c06067

Hydrophilic/Hydrophobic Heterogeneity Anti-Biofouling Hydrogels with Well-Regulated Rehydration
DOI: 10.1021/acsami.0c05406

Preface: Forum on Advances in Biocidal Materials and Interfaces
This article is part of the Advances in Biocidal Materials and Interfaces special issue.
DOI: 10.1021/acsami.0c06495

Smart Glove Integrated with Tunable MWNTs/PDMS Fibers Made of a One-Step Extrusion Method for Finger Dexterity, Gesture, and Temperature Recognition
DOI: 10.1021/acsami.0c08114



ACS Applied Nano Materials

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Manuscript Titles: How to Capture Readers and Enhance Citations
DOI: 10.1021/acsanm.0c01089

Using Site Heterogeneity in Metal–Organic Frameworks with Bimetallic Open Metal Sites for Olefin/Paraffin Separations
DOI: 10.1021/acsanm.0c00693

Controlling Pt Crystal Defects on the Surface of Ni–Pt Core–Shell Nanoparticles for Active and Stable Electrocatalysts for Oxygen Reduction
DOI: 10.1021/acsanm.0c01159

CaCl2-Activated Carbon Nitride: Hierarchically Nanoporous Carbons with Ultrahigh Nitrogen Content for Selective CO2 Adsorption
DOI: 10.1021/acsanm.0c01112

Pt Nanoparticles Supported on N-Doped Porous Carbon Derived from Metal–Organic Frameworks for Oxygen Reduction
DOI: 10.1021/acsanm.0c00906



ACS Applied Polymer Materials

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Hierarchical Photocomposition of Heteronanostructures in a Surfactant–Polysiloxane Hybrid Film toward Next-Generation Nanolithography
DOI: 10.1021/acsapm.0c00253

Flexible Polyimide Aerogels Derived from the Use of a Neopentyl Spacer in the Backbone
DOI: 10.1021/acsapm.0c00153

Surfactant-Free Latex Nanocomposites Stabilized and Reinforced by Hydrophobically Functionalized Cellulose Nanocrystals
DOI: 10.1021/acsapm.0c00263

Unprecedented Sour Mixed-Gas Permeation Properties of Fluorinated Polyazole-Based Membranes
DOI: 10.1021/acsapm.0c00196

Recyclable Polyethylene Insulation via Reactive Compounding with a Maleic Anhydride-Grafted Polypropylene
Open Access through ACS AuthorChoice
DOI: 10.1021/acsapm.0c00320



ACS Biomaterials Science & Engineering

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Special Issue: Leaders in Biomedical Engineering
This article is part of the Leaders in Biomedical Engineering special issue.
DOI: 10.1021/acsbiomaterials.0c00606

Sulfation Modulates the Targeting Properties of Hyaluronic Acid to P-Selectin and CD44
DOI: 10.1021/acsbiomaterials.0c00115

A Defined and Scalable Peptide-Based Platform for the Generation of Human Pluripotent Stem Cell-Derived Astrocytes
Open Access through ACS AuthorChoice
DOI: 10.1021/acsbiomaterials.0c00067

Antiviral and Antibacterial Nanostructured Surfaces with Excellent Mechanical Properties for Hospital Applications
DOI: 10.1021/acsbiomaterials.0c00348

Biomimetic Gelatin Methacrylate/Nano Fish Bone Hybrid Hydrogel for Bone Regeneration via Osteoimmunomodulation
DOI: 10.1021/acsbiomaterials.0c00443



ACS Catalysis

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Hydroarylation of Alkenes Using Anilines in Hexafluoroisopropanol
DOI: 10.1021/acscatal.0c00872

Catalytic β-Functionalization of Carbonyl Compounds Enabled by α,β-Desaturation
DOI: 10.1021/acscatal.0c01519

Regioselective Cross-Electrophile Coupling of Epoxides and (Hetero)aryl Iodides via Ni/Ti/Photoredox Catalysis
DOI: 10.1021/acscatal.0c01199

Development of Ketone-Based Brominating Agents (KBA) for the Practical Asymmetric α-Bromination of Aldehydes Catalyzed by Tritylpyrrolidine
DOI: 10.1021/acscatal.0c01596

Decarboxylative Hydroalkylation of Alkynes via Dual Copper-Photoredox Catalysis
DOI: 10.1021/acscatal.0c01742



ACS Central Science

***

Remdesivir: A Review of Its Discovery and Development Leading to Emergency Use Authorization for Treatment of COVID-19
Open Access through ACS AuthorChoice
DOI: 10.1021/acscentsci.0c00489

An Outlook on Low-Volume-Change Lithium Metal Anodes for Long-Life Batteries
Open Access through ACS AuthorChoice
DOI: 10.1021/acscentsci.0c00351

Chrysomycin A Derivatives for the Treatment of Multi-Drug-Resistant Tuberculosis
Open Access through ACS AuthorChoice
DOI: 10.1021/acscentsci.0c00122

Solution-Processed, Large-Area, Two-Dimensional Crystals of Organic Semiconductors for Field-Effect Transistors and Phototransistors
Open Access through ACS AuthorChoice
DOI: 10.1021/acscentsci.0c00251

Let’s Make White Phosphorus Obsolete
Open Access through ACS AuthorChoice
DOI: 10.1021/acscentsci.0c00332



ACS Chemical Biology

***

When the Others Become Us: A Chemist’s Perspective of the COVID-19 Outbreak in Italy
Open Access through ACS AuthorChoice
DOI: 10.1021/acschembio.0c00289

Advancing Chemical Microbiology
This article is part of the Chemical Microbiology special issue.
DOI: 10.1021/acschembio.0c00330

Peptide Probes for Plasmodium falciparum MyoA Tail Interacting Protein (MTIP): Exploring the Druggability of the Malaria Parasite Motor Complex
Open Access through ACS AuthorChoice
DOI: 10.1021/acschembio.0c00328

Covalent Targeting of Ras G12C by Rationally Designed Peptidomimetics
DOI: 10.1021/acschembio.0c00204

Light-Driven Activation of RNA-Guided Nucleic Acid Cleavage
DOI: 10.1021/acschembio.0c00105



ACS Chemical Health & Safety

***

COVID-19: A Risk Assessment Perspective
Open Access through ACS AuthorChoice
DOI: 10.1021/acs.chas.0c00035

Getting Back to the Lab during COVID-19: Careful planning and lots of distancing are critical for R&D labs that have stayed open and those looking to restart
Open Access through ACS AuthorChoice
DOI: 10.1021/acs.chas.0c00056

Ten Years after the Texas Tech Accident. Part II: Changing Safety Cultures and the Current State of Academic Laboratory Safety at Texas Tech University
DOI: 10.1021/acs.chas.0c00047

Development and Implementation of a Hydrofluoric Acid Safety Program in an Academic Institution
DOI: 10.1021/acs.chas.0c00008

Let’s Disagree about Safety
DOI: 10.1021/acs.chas.0c00050



ACS Chemical Neuroscience

***

Expression of the SARS-CoV-2 Entry Proteins, ACE2 and TMPRSS2, in Cells of the Olfactory Epithelium: Identification of Cell Types and Trends with Age
Open Access through ACS AuthorChoice
DOI: 10.1021/acschemneuro.0c00210

Autonomic Brain Centers and Pathophysiology of COVID-19
Open Access through ACS AuthorChoice
DOI: 10.1021/acschemneuro.0c00265

Proposed Intranasal Route for Drug Administration in the Management of Central Nervous System Manifestations of COVID-19
Open Access through ACS AuthorChoice
DOI: 10.1021/acschemneuro.0c00288

NeuroChat with Dr. Karen Gregory
DOI: 10.1021/acschemneuro.0c00183

A Master Regulator of α-Synuclein Aggregation
DOI: 10.1021/acschemneuro.0c00216



ACS Combinatorial Science

***

Direct, Competitive Comparison of Linear, Monocyclic, and Bicyclic Libraries Using mRNA Display
Open Access through ACS Editors’ Choice
DOI: 10.1021/acscombsci.0c00016

Targeting the Dimerization of the Main Protease of Coronaviruses: A Potential Broad-Spectrum Therapeutic Strategy
Open Access through ACS AuthorChoice
DOI: 10.1021/acscombsci.0c00058

Development of High-Throughput Methods for Sodium-Ion Battery Cathodes
DOI: 10.1021/acscombsci.9b00181

Electrochemical Screening of Metallic ORR Catalyst Thin Films Using Getter Co-Sputtering
DOI: 10.1021/acscombsci.0c00005

Scaffolding-Induced Property Modulation of Chemical Space
Open Access through ACS AuthorChoice
DOI: 10.1021/acscombsci.0c00072



ACS Earth and Space Chemistry

***

Aqueous-Phase Photooxidation of Vanillic Acid: A Potential Source of Humic-Like Substances (HULIS)
DOI: 10.1021/acsearthspacechem.0c00070

Tropospheric Photo-oxidation of Ethyl Methacrylate Initiated by Cl Atoms in the Gas Phase: Kinetic and Mechanistic Investigations
DOI: 10.1021/acsearthspacechem.0c00018

Real-Time Measurements of pH Changes in Single Acoustically Levitated Droplets Due to Atmospheric Multiphase Chemistry
DOI: 10.1021/acsearthspacechem.0c00041

Impact of Hydrogen Sulfide on Photochemical Haze Formation in Methane/Nitrogen Atmospheres
DOI: 10.1021/acsearthspacechem.0c00086

Ferrous Iron Addition Decreases Methane Emissions Induced by Rice Straw in Flooded Paddy Soils
DOI: 10.1021/acsearthspacechem.0c00024



ACS Energy Letters

***

COVID-19, Climate Change, and Renewable Energy Research: We Are All in This Together, and the Time to Act Is Now
Open Access through ACS AuthorChoice
DOI: 10.1021/acsenergylett.0c00910

The Role of Dimethylammonium in Bandgap Modulation for Stable Halide Perovskites
DOI: 10.1021/acsenergylett.0c00872

Stable Hexylphosphonate-Capped Blue-Emitting Quantum-Confined CsPbBr3 Nanoplatelets
Open Access through ACS AuthorChoice
DOI: 10.1021/acsenergylett.0c00935

A Robust, Scalable Platform for the Electrochemical Conversion of CO2 to Formate: Identifying Pathways to Higher Energy Efficiencies
DOI: 10.1021/acsenergylett.0c00860

CsPbBr3/ZnS Core/Shell Type Nanocrystals for Enhancing Luminescence Lifetime and Water Stability
DOI: 10.1021/acsenergylett.0c00858



ACS Infectious Diseases

***

Endogenous Deficiency of Glutathione as the Most Likely Cause of Serious Manifestations and Death in COVID-19 Patients
Open Access through ACS AuthorChoice
DOI: 10.1021/acsinfecdis.0c00288

Are Quaternary Ammonium Compounds, the Workhorse Disinfectants, Effective against Severe Acute Respiratory Syndrome-Coronavirus-2?
Open Access through ACS AuthorChoice
DOI: 10.1021/acsinfecdis.0c00265

COVID-19: Living through Another Pandemic
Open Access through ACS AuthorChoice
DOI: 10.1021/acsinfecdis.0c00224

The Global Antibiotic Research and Development Partnership (GARDP) Not-for-Profit Model of Antibiotic Development
DOI: 10.1021/acsinfecdis.0c00101

Characterization and noncovalent inhibition of the deubiquitinase and deISGylase activity of SARS-CoV-2 papain-like protease
Open Access through ACS AuthorChoice
DOI: 10.1021/acsinfecdis.0c00168



ACS Macro Letters

***

Self-Healing Injectable Polymer Hydrogel via Dynamic Thiol-Alkynone Double Addition Cross-Links
Open Access through ACS AuthorChoice
DOI: 10.1021/acsmacrolett.0c00241

Rapid Synthesis of Elastomers and Thermosets with Tunable Thermomechanical Properties
Open Access through ACS Editors’ Choice
DOI: 10.1021/acsmacrolett.0c00233

Vitrimerization: Converting Thermoset Polymers into Vitrimers
DOI: 10.1021/acsmacrolett.0c00299

Constructing Thermally Reversible Dynamic Hydrogels via Catalysis-Free Knoevenagel Condensation
DOI: 10.1021/acsmacrolett.0c00330

Dewar Heterocycles as Versatile Monomers for Ring-Opening Metathesis Polymerization
DOI: 10.1021/acsmacrolett.0c00227



ACS Materials Letters

***

Atmospheric Water Harvesting: A Review of Material and Structural Designs
Open Access through ACS Editors’ Choice
DOI: 10.1021/acsmaterialslett.0c00130

Controlling the Lithium-Metal Growth To Enable Low-Lithium-Metal-Excess All-Solid-State Lithium-Metal Batteries
Open Access through ACS AuthorChoice
DOI: 10.1021/acsmaterialslett.0c00152

The Origin of Dual Emission in Antiparallel-Stacked Two-Dimensional Covalent Organic Frameworks
DOI: 10.1021/acsmaterialslett.0c00119

Amorphous Multimetal Alloy Oxygen Evolving Catalysts
DOI: 10.1021/acsmaterialslett.0c00146

Highly Stable Organic Antimony Halide Crystals for X-ray Scintillation
DOI: 10.1021/acsmaterialslett.0c00133



ACS Medicinal Chemistry Letters

***

Blocking Coronavirus 19 Infection via the SARS-CoV-2 Spike Protein: Initial Steps
Open Access through ACS AuthorChoice
DOI: 10.1021/acsmedchemlett.0c00233

Ligand Design for Cereblon Based Immunomodulatory Therapy
DOI: 10.1021/acsmedchemlett.0c00214

PROTAC Compounds Targeting TRK for Use in Cancer Therapeutics
DOI: 10.1021/acsmedchemlett.0c00235

PROTAC Compounds Targeting Androgen Receptor for Cancer Therapeutics: Prostate Cancer and Kennedy’s Disease
DOI: 10.1021/acsmedchemlett.0c00236

De-risking Drug Discovery of Intracellular Targeting Peptides: Screening Strategies to Eliminate False-Positive Hits
DOI: 10.1021/acsmedchemlett.0c00022



ACS Nano

***

Can N95 Respirators Be Reused after Disinfection? How Many Times?
Open Access through ACS AuthorChoice
DOI: 10.1021/acsnano.0c03597

Considering the Effects of Microbiome and Diet on SARS-CoV-2 Infection: Nanotechnology Roles
Open Access through ACS AuthorChoice
DOI: 10.1021/acsnano.0c03402

Flexible Nanoporous Template for the Design and Development of Reusable Anti-COVID-19 Hydrophobic Face Masks
Open Access through ACS AuthorChoice
DOI: 10.1021/acsnano.0c03976

Leveraging Hierarchical Self-Assembly Pathways for Realizing Colloidal Photonic Crystals
Open Access through ACS AuthorChoice
DOI: 10.1021/acsnano.9b07849

Melbourne—Australia’s Science City
DOI: 10.1021/acsnano.0c04003



ACS Omega

***

Advanced Mechanochemistry Device for Sustainable Synthetic Processes
Open Access through ACS AuthorChoice
DOI: 10.1021/acsomega.0c00521

Cobalt Colloid-derived Efficient and Durable Nanoscale Electrocatalytic Films for High-Activity Water Oxidation
Open Access through ACS AuthorChoice
DOI: 10.1021/acsomega.9b03576

Rapid Detection of IgM Antibodies against the SARS-CoV-2 Virus via Colloidal Gold Nanoparticle-Based Lateral-Flow Assay
Open Access through ACS AuthorChoice
DOI: 10.1021/acsomega.0c01554

Carbazole/Benzimidazole-Based Bipolar Molecules as the Hosts for Phosphorescent and Thermally Activated Delayed Fluorescence Emitters for Efficient OLEDs
Open Access through ACS AuthorChoice
DOI: 10.1021/acsomega.0c00967

Mechanistic Insights into Zika Virus NS3 Helicase Inhibition by Epigallocatechin-3-Gallate
Open Access through ACS AuthorChoice
DOI: 10.1021/acsomega.0c01353



ACS Pharmacology & Translational Science

***

Characterization of the Core Ribosomal Binding Region for the Oxazolidone Family of Antibiotics Using Cryo-EM
DOI: 10.1021/acsptsci.0c00041

Rapid and Point-of-Care Testing in Respiratory Tract Infections: An Antibiotic Guardian?
Open Access through ACS AuthorChoice
DOI: 10.1021/acsptsci.0c00027

Modulation of Lymphocyte Potassium Channel KV1.3 by Membrane-Penetrating, Joint-Targeting Immunomodulatory Plant Defensin
Open Access through ACS Editors’ Choice
DOI: 10.1021/acsptsci.0c00035

Physiologically-based population pharmacokinetic modeling approach for ciprofloxacin in bone of patients undergoing orthopedic surgery
DOI: 10.1021/acsptsci.0c00045



ACS Photonics

***

Microwave Programmable Graphene Metasurface
DOI: 10.1021/acsphotonics.9b01807

Design of Selective Reflectors Utilizing Multiple Scattering by Core–Shell Nanoparticles for Color Conversion Films
DOI: 10.1021/acsphotonics.0c00117

Photonic Nanojet Mediated Backaction of Dielectric Microparticles
DOI: 10.1021/acsphotonics.0c00242

Metasurface Generation of Paired Accelerating and Rotating Optical Beams for Passive Ranging and Scene Reconstruction
DOI: 10.1021/acsphotonics.0c00354

Quantum-Memory-Enabled Ultrafast Optical Switching in Carbon Nanotubes
DOI: 10.1021/acsphotonics.0c00315



ACS Sensors

***

Giants in Sensing: A Virtual Issue to Celebrate Five Years of ACS Sensors
DOI: 10.1021/acssensors.0c00875

Epidermal Enzymatic Biosensors for Sweat Vitamin C: Toward Personalized Nutrition
DOI: 10.1021/acssensors.0c00604

Detect to Protect
Open Access through ACS AuthorChoice
DOI: 10.1021/acssensors.0c00920

Virus Detection: What Were We Doing before COVID-19 Changed the World?
Open Access through ACS AuthorChoice
DOI: 10.1021/acssensors.0c01029

Sequence-Specific Recognition of HIV-1 DNA with Solid-State CRISPR-Cas12a-Assisted Nanopores (SCAN)
DOI: 10.1021/acssensors.0c00497



ACS Sustainable Chemistry & Engineering

***

Functionalization of Nitrogen-Doped Carbon Nanofibers with Polyamidoamine Dendrimer as a Freestanding Electrode with High Sulfur Loading for Lithium–Polysulfides Batteries
DOI: 10.1021/acssuschemeng.0c00300

Worthy and Necessary Challenges
DOI: 10.1021/acssuschemeng.0c02881

Methanol-Based Chain Elongation with Acetate to n-Butyrate and Isobutyrate at Varying Selectivities Dependent on pH
Open Access through ACS AuthorChoice
DOI: 10.1021/acssuschemeng.0c00907

Efficient and Easily Reusable Metal-Free Heterogeneous Catalyst Beads for the Conversion of CO2 into Cyclic Carbonates in the Presence of Water as Hydrogen-Bond Donor
Open Access through ACS AuthorChoice
DOI: 10.1021/acssuschemeng.0c02265

Perspective on Technical Lignin Fractionation
DOI: 10.1021/acssuschemeng.0c01348



ACS Symposium Series

***

A Polymer Physics Perspective on Why PEI Is an Effective Nonviral Gene Delivery Vector
DOI: 10.1021/bk-2020-1350.ch001

Preface
DOI: 10.1021/bk-2020-1350.pr001

Cellular Delivery of Hoechst 33342 Anticancer Drug from Crosslinked Poly(thioether anhydrides): A Cytotoxicity and Efficacy Study
DOI: 10.1021/bk-2020-1350.ch006

Recent Advancements in Arrayed Technologies and Emerging Themes in the Identification of Glycan-Protein Interactions
DOI: 10.1021/bk-2020-1346.ch001

Metal–Organic Nanomaterials for Drug Delivery
DOI: 10.1021/bk-2020-1350.ch007



ACS Synthetic Biology

***

Automated Continuous Evolution of Proteins in Vivo
DOI: 10.1021/acssynbio.0c00135

Bottom-Up Construction of a Minimal System for Cellular Respiration and Energy Regeneration
Open Access through ACS AuthorChoice
DOI: 10.1021/acssynbio.0c00110

High-Throughput Screening for Substrate Specificity-Adapted Mutants of the Nisin Dehydratase NisB
Open Access through ACS AuthorChoice
DOI: 10.1021/acssynbio.0c00130

Cell-Free Bacteriophage Genome Synthesis Using Low-Cost Sequence-Verified Array-Synthesized Oligonucleotides
DOI: 10.1021/acssynbio.0c00051

Two-Component Biosensors: Unveiling the Mechanisms of Predictable Tunability
DOI: 10.1021/acssynbio.0c00010



Analytical Chemistry

***

Real-Time In-Organism NMR Metabolomics Reveals Different Roles of AMP-Activated Protein Kinase Catalytic Subunits
DOI: 10.1021/acs.analchem.9b05670

Paper-Based Constant Potential Electrochemiluminescence Sensing Platform with Black Phosphorus as a Luminophore Enabled by a Perovskite Solar Cell
DOI: 10.1021/acs.analchem.0c01033

MicroRNA-Initiated and Intracellular Na+-Fueled DNAzyme Motor for Differentiating Molecular Subtypes of Nonsmall Cell Lung Cancer
DOI: 10.1021/acs.analchem.0c01134

Sub-zeptomole Detection of Biomarker Proteins Using a Microfluidic Immunoarray with Nanostructured Sensors
DOI: 10.1021/acs.analchem.0c01507

“Switch-On” Fluorescence Detection of Glucose with High Specificity and Sensitivity Based on Silver Nanoparticles Supported on Porphyrin Metal–Organic Frameworks
DOI: 10.1021/acs.analchem.0c01651



Biochemistry

***

A Jumbo Phage Forms a Nucleus-like Compartment to Evade Bacterial Defense Systems
DOI: 10.1021/acs.biochem.0c00273

Dimeric Stilbene Antibiotics Target the Bacterial Cell Wall in Drug-Resistant Gram-Positive Pathogens
DOI: 10.1021/acs.biochem.0c00213

Probing the Conformational Changes Associated with DNA Binding to PARP1
DOI: 10.1021/acs.biochem.0c00256

Global Profiling of Cellular Substrates of Human Dcp2
DOI: 10.1021/acs.biochem.0c00069

Evidence of an Unusual Poly(A) RNA Signature Detected by High-Throughput Chemical Mapping
DOI: 10.1021/acs.biochem.0c00215



Bioconjugate Chemistry

***

Precise Installation of Diazo-Tagged Side-Chains on Proteins to Enable In Vitro and In-Cell Site-Specific Labeling
Open Access through ACS Editors’ Choice
DOI: 10.1021/acs.bioconjchem.0c00232

Conjugated Protein Domains as Engineered Scaffold Proteins
Open Access through ACS AuthorChoice
DOI: 10.1021/acs.bioconjchem.0c00183

Fluorescent Labeling of Proteins of Interest in Live Cells: Beyond Fluorescent Proteins
DOI: 10.1021/acs.bioconjchem.0c00181

An Artificial Amphiphilic Peptide Promotes Endocytic Uptake by Inducing Membrane Curvature
DOI: 10.1021/acs.bioconjchem.0c00239

In Situ One-Step Fluorescence Labeling Strategy of Exosomes via Bioorthogonal Click Chemistry for Real-Time Exosome Tracking In Vitro and In Vivo
DOI: 10.1021/acs.bioconjchem.0c00216



Biomacromolecules

***

Injectable Antimicrobial Conductive Hydrogels for Wound Disinfection and Infectious Wound Healing
DOI: 10.1021/acs.biomac.9b01732

Renewable Molecules & Materials: Anselme Payen Award Symposium in Honor of Ann-Christine Albertsson
DOI: 10.1021/acs.biomac.0c00507

Synthesis of Zwitterionic and Trehalose Polymers with Variable Degradation Rates and Stabilization of Insulin
DOI: 10.1021/acs.biomac.0c00133

Functionalization of Cellulose Nanocrystals with POEGMA Copolymers via Copper-Catalyzed Azide–Alkyne Cycloaddition for Potential Drug-Delivery Applications
DOI: 10.1021/acs.biomac.9b01713

Chiral Nematic Liquid Crystal Behavior of Core–Shell Hybrid Rods Consisting of Chiral Cellulose Nanocrystals Dressed with Non-chiral Conformal Polymeric Skins
DOI: 10.1021/acs.biomac.0c00320



C&EN Global Enterprise

***

Hair color chemistry gets a fresh look
DOI: 10.1021/cen-09817-cover

Getting back to the lab during COVID-19
DOI: 10.1021/cen-09819-cover

Advancing sustainability in the pharmaceutical industry
DOI: 10.1021/cen-09817-comment

Rethinking the role of blood pressure drugs in COVID-19
DOI: 10.1021/cen-09820-cover

Navigating the coronavirus job crisis
DOI: 10.1021/cen-09818-cover



Chemical Research in Toxicology

***

Advanced In Vitro Testing Strategies and Models of the Intestine for Nanosafety Research
DOI: 10.1021/acs.chemrestox.0c00079

Special Issue on “Future Nanosafety”
This article is part of the Future Nanosafety special issue.
DOI: 10.1021/acs.chemrestox.0c00166

Ensemble Models Based on QuBiLS-MAS Features and Shallow Learning for the Prediction of Drug-Induced Liver Toxicity: Improving Deep Learning and Traditional Approaches
DOI: 10.1021/acs.chemrestox.0c00030

Interactions of Perfluorooctanesulfonate and 6:2 Chlorinated Polyfluorinated Ether Sulfonate with Human Serum Albumin: A Comparative Study
DOI: 10.1021/acs.chemrestox.0c00075

Arsenic Exposure and Compromised Protein Quality Control
DOI: 10.1021/acs.chemrestox.0c00107



Chemical Reviews

***

Metal–Organic Framework-Based Catalysts with Single Metal Sites
DOI: 10.1021/acs.chemrev.9b00757

Water and Metal–Organic Frameworks: From Interaction toward Utilization
Open Access Through ACS AuthorChoice
This article is part of the Porous Framework Chemistry special issue.
DOI: 10.1021/acs.chemrev.9b00746

Bioprinting: From Tissue and Organ Development to in Vitro Models
Open Access Through ACS AuthorChoice
This article is part of the 3D Printing for Biomaterials special issue.
DOI: 10.1021/acs.chemrev.9b00789

Functional Supramolecular Polymeric Networks: The Marriage of Covalent Polymers and Macrocycle-Based Host–Guest Interactions
DOI: 10.1021/acs.chemrev.9b00839

Activation of Dinitrogen by Polynuclear Metal Complexes
DOI: 10.1021/acs.chemrev.0c00042



Chemistry of Materials

***

Mechanochemical Grafting: A Solvent-less Highly Efficient Method for the Synthesis of Hybrid Inorganic–Organic Materials
Open Access Through ACS AuthorChoice
DOI: 10.1021/acs.chemmater.0c01266

Uncovering the Role of Metal–Organic Framework Topology on the Capture and Reactivity of Chemical Warfare Agents
DOI: 10.1021/acs.chemmater.0c00986

Continuous Nucleation and Size Dependent Growth Kinetics of Indium Phosphide Nanocrystals
DOI: 10.1021/acs.chemmater.0c01561

All-Lignin-Based Hydrogel with Fast pH-Stimuli Responsiveness for Mechanical Switching and Actuation
DOI: 10.1021/acs.chemmater.0c01198

Highly Emissive Semi-Ladder-Type Copolymers, Aggregation State, and Solution-Processed Organic Light-Emitting Transistor
DOI: 10.1021/acs.chemmater.0c01168



Crystal Growth & Design

***

Recognition-Control and Host–Guest Interactions in High-Symmetry Cocrystals of Fullerenes with Cubane and Mesitylene
Open Access Through ACS AuthorChoice
DOI: 10.1021/acs.cgd.0c00440

Temperature-Dependent Supramolecular Isomeric Zn(II)-Metal–Organic Frameworks and Their Guest Exchange
DOI: 10.1021/acs.cgd.0c00443

Bottom-Up Growth of Shape-Engineered Molecular Single Crystals
DOI: 10.1021/acs.cgd.0c00194

Tuning Physicochemical Properties of Antipsychotic Drug Aripiprazole with Multicomponent Crystal Strategy Based on Structure and Property Relationship
DOI: 10.1021/acs.cgd.0c00022

Generation and Evaluation of Pharmacologically Relevant Drug–Drug Cocrystal for Gout Therapy
DOI: 10.1021/acs.cgd.0c00106



Energy & Fuels

***

Laminar Burning Velocities and Kinetic Modeling of a Renewable E-Fuel: Formic Acid and Its Mixtures with H2 and CO2
Open Access Through ACS AuthorChoice
DOI: 10.1021/acs.energyfuels.0c00944

Overview of Asphaltene Nanostructures and Thermodynamic Applications
DOI: 10.1021/acs.energyfuels.0c00874

Efficient Depolymerization of Alkaline Lignin to Phenolic Compounds at Low Temperatures with Formic Acid over Inexpensive Fe–Zn/Al2O3 Catalyst
DOI: 10.1021/acs.energyfuels.0c00742

Microwave-Assisted Dry and Bi-reforming of Methane over M–Mo/TiO2 (M = Co, Cu) Bimetallic Catalysts
DOI: 10.1021/acs.energyfuels.0c00757

Recovery of Hydrogen and Sulfur by Electrolysis of Ionized H2S in an Amine-Containing Organic Electrolyte with Highly Temperature-Dependent Sulfur Solubility
DOI: 10.1021/acs.energyfuels.0c01161



Environmental Science & Technology

***

Potential Sensitivity of Wastewater Monitoring for SARS-CoV-2: Comparison with Norovirus Cases
Open Access Through ACS AuthorChoice
DOI: 10.1021/acs.est.0c02271

An (Eco)Toxicity Life Cycle Impact Assessment Framework for Per- And Polyfluoroalkyl Substances
Open Access Through ACS AuthorChoice
DOI: 10.1021/acs.est.9b07774

Retrospective Risk Assessment of Chemical Mixtures in the Big Data Era: An Alternative Classification Strategy to Integrate Chemical and Toxicological Data
DOI: 10.1021/acs.est.0c01062

Evolving Today to Best Serve Tomorrow
DOI: 10.1021/acs.est.0c02360

Balancing Privacy Rights and the Production of High-Quality Satellite Imagery
DOI: 10.1021/acs.est.0c02365



Environmental Science & Technology Letters

***

Exotic Electrophiles in Chlorinated and Chloraminated Water: When Conventional Kinetic Models and Reaction Pathways Fall Short
Open Access Through ACS Editors’ Choice
DOI: 10.1021/acs.estlett.0c00259

Substantial Changes in Nitrogen Dioxide and Ozone after Excluding Meteorological Impacts during the COVID-19 Outbreak in Mainland China
Open Access Through ACS AuthorChoice
DOI: 10.1021/acs.estlett.0c00304

Presence of SARS-Coronavirus-2 RNA in Sewage and Correlation with Reported COVID-19 Prevalence in the Early Stage of the Epidemic in The Netherlands
Open Access Through ACS AuthorChoice
DOI: 10.1021/acs.estlett.0c00357

μ-MIP: Molecularly Imprinted Polymer-Modified Microelectrodes for the Ultrasensitive Quantification of GenX (HFPO-DA) in River Water
Open Access Through ACS Editors’ Choice
DOI: 10.1021/acs.estlett.0c00341

Observational Evidence for the Involvement of Dicarboxylic Acids in Particle Nucleation
DOI: 10.1021/acs.estlett.0c00270



Industrial & Engineering Chemistry Research

***

Chemical Degradation of End-of-Life Poly(lactic acid) into Methyl Lactate by a Zn(II) Complex
Open Access Through ACS AuthorChoice
DOI: 10.1021/acs.iecr.0c01122

OHM Sponge: A Versatile, Efficient, and Ecofriendly Environmental Remediation Platform
DOI: 10.1021/acs.iecr.0c01493

Novel Adsorption Process for Co-Production of Hydrogen and CO2 from a Multicomponent Stream—Part 2: Application to Steam Methane Reforming and Autothermal Reforming Gases
Open Access Through ACS AuthorChoice
DOI: 10.1021/acs.iecr.9b06953

Electro-Enhanced Membrane Sorption: A New Approach for Selective Ion Separation and Its Application to Phosphate and Arsenic Removal
DOI: 10.1021/acs.iecr.0c01498

Zeolitic Imidazolate Framework-67-Derived CeO2@Co3O4 Core–Shell Microspheres with Enhanced Catalytic Activity toward Toluene Oxidation
DOI: 10.1021/acs.iecr.9b07028



Inorganic Chemistry

***

A Safe Return
Open Access Through ACS AuthorChoice
DOI: 10.1021/acs.inorgchem.0c01253

Enhanced Water Dispersibility of Discrete Chalcogenide Nanoclusters with a Sodalite-Net Loose-Packing Pattern in a Crystal Lattice
Open Access Through ACS Editors’ Choice
DOI: 10.1021/acs.inorgchem.0c00621

Ruthenium 4d-to-2p X-ray Emission Spectroscopy: A Simultaneous Probe of the Metal and the Bound Ligands
Open Access Through ACS AuthorChoice
DOI: 10.1021/acs.inorgchem.0c00663

Forcing Dicyanamide Coordination to f-Elements by Dissolution in Dicyanamide-Based Ionic Liquids
Open Access Through ACS AuthorChoice
DOI: 10.1021/acs.inorgchem.0c00667

Alkyne Functionalization of a Photoactivated Ruthenium Polypyridyl Complex for Click-Enabled Serum Albumin Interaction Studies
Open Access Through ACS AuthorChoice
DOI: 10.1021/acs.inorgchem.0c00742



Journal of Agricultural and Food Chemistry

***

Occurrence and Fate of Natural Estrogens in Swiss Cattle and Pig Slurry
Open Access Through ACS AuthorChoice
DOI: 10.1021/acs.jafc.0c00858

Investigation of Chocolate Matrix Interference on Cannabinoid Analytes
DOI: 10.1021/acs.jafc.0c01161

Discovery of Tryptanthrins as Novel Antiviral and Anti-Phytopathogenic-Fungus Agents
DOI: 10.1021/acs.jafc.0c02101

Hepatic Lipidomics Analysis Reveals the Antiobesity and Cholesterol-Lowering Effects of Tangeretin in High-Fat Diet-Fed Rats
DOI: 10.1021/acs.jafc.0c01778

Protective Mechanism of Common Buckwheat (Fagopyrum esculentum Moench.) against Nonalcoholic Fatty Liver Disease Associated with Dyslipidemia in Mice Fed a High-Fat and High-Cholesterol Diet
DOI: 10.1021/acs.jafc.9b08211



Journal of Chemical & Engineering Data

***

Nuclear Magnetic Resonance (NMR) Spectroscopy for the In Situ Measurement of Vapor–Liquid Equilibria
Open Access Through ACS AuthorChoice
This article is part of the Nontraditional Techniques for Measurement of Phase Equilibria special issue.
DOI: 10.1021/acs.jced.0c00113

Isobaric Vapor–Liquid Equilibria for Binary Mixtures of Biomass-Derived γ-Valerolactone + Tetrahydrofuran and 2-Methyltetrahydrofuran
Open Access Through ACS AuthorChoice
DOI: 10.1021/acs.jced.0c00084

Heat of Adsorption: A Comparative Study between the Experimental Determination and Theoretical Models Using the System CH4-MOFs
DOI: 10.1021/acs.jced.0c00159

Development of Multivalent Metal-Ion-Fabricated Fumaric Acid-Based Metal–Organic Frameworks for Defluoridation of Water
DOI: 10.1021/acs.jced.0c00005

Entropy Scaling of Viscosity—I: A Case Study of Propane
DOI: 10.1021/acs.jced.0c00209



Journal of Chemical Education

***

An Arduino-Based Talking Calorimeter for Inclusive Lab Activities
DOI: 10.1021/acs.jchemed.0c00148

Establishing the Laboratory as the Place to Learn How to Do Chemistry
DOI: 10.1021/acs.jchemed.9b00764

Chemistry Education in Times of Disruption and the Times That Lie Beyond
DOI: 10.1021/acs.jchemed.0c00377

Writing the 2019 ACS Exam for Chemical Health and Safety
This article is part of the Chemical Safety Education: Methods, Culture, and Green Chemistry special issue.
DOI: 10.1021/acs.jchemed.0c00124

Development of a Large-Enrollment Course-Based Research Experience in an Undergraduate Organic Chemistry Laboratory: Structure–Function Relationships in Pyrylium Photoredox Catalysts
DOI: 10.1021/acs.jchemed.9b00786



Journal of Chemical Information and Modeling

***

Scope of 3D Shape-Based Approaches in Predicting the Macromolecular Targets of Structurally Complex Small Molecules Including Natural Products and Macrocyclic Ligands
Open Access Through ACS AuthorChoice
DOI: 10.1021/acs.jcim.0c00161

ADME Prediction with KNIME: Development and Validation of a Publicly Available Workflow for the Prediction of Human Oral Bioavailability
DOI: 10.1021/acs.jcim.0c00019

Matched Molecular Series Analysis for ADME Property Prediction
DOI: 10.1021/acs.jcim.0c00269

Practical Considerations for Atomistic Structure Modeling with Cryo-EM Maps
DOI: 10.1021/acs.jcim.0c00090

Loop Grafting between Similar Local Environments for Fc-Silent Antibodies
Open Access Through ACS AuthorChoice
This article is part of the Novel Directions in Free Energy Methods and Applications special issue.
DOI: 10.1021/acs.jcim.9b01198



Journal of Chemical Theory and Computation

***

Determining Free-Energy Differences Through Variationally Derived Intermediates
Open Access Through ACS AuthorChoice
DOI: 10.1021/acs.jctc.0c00106

Restricted-Variance Molecular Geometry Optimization Based on Gradient-Enhanced Kriging
Open Access Through ACS AuthorChoice
DOI: 10.1021/acs.jctc.0c00257

Coarse-Grained Molecular Model for the Glycosylphosphatidylinositol Anchor with and without Protein
Open Access Through ACS AuthorChoice
DOI: 10.1021/acs.jctc.0c00056

Validation of Pseudopotential Calculations for the Electronic Band Gap of Solids
Open Access Through ACS AuthorChoice
DOI: 10.1021/acs.jctc.0c00214

Protein Structure Prediction in CASP13 Using AWSEM-Suite
DOI: 10.1021/acs.jctc.0c00188



Journal of Medicinal Chemistry

***

A Fast and Clean BTK Inhibitor
Open Access Through ACS AuthorChoice
DOI: 10.1021/acs.jmedchem.0c00597

Discovery of SHP2-D26 as a First, Potent, and Effective PROTAC Degrader of SHP2 Protein
DOI: 10.1021/acs.jmedchem.0c00471

Learning Molecular Representations for Medicinal Chemistry Miniperspective
DOI: 10.1021/acs.jmedchem.0c00385

Discovery of BMS-986235/LAR-1219: A Potent Formyl Peptide Receptor 2 (FPR2) Selective Agonist for the Prevention of Heart Failure
DOI: 10.1021/acs.jmedchem.9b02101

Discovery of a First-in-Class Protein Arginine Methyltransferase 6 (PRMT6) Covalent Inhibitor
DOI: 10.1021/acs.jmedchem.0c00406



Journal of Natural Products

***

A DNA Repair Inhibitor Isolated from an Ecuadorian Fungal Endophyte Exhibits Synthetic Lethality in PTEN-Deficient Glioblastoma
DOI: 10.1021/acs.jnatprod.0c00012

Inhibitory Effect of Cannabidiol on the Activation of NLRP3 Inflammasome Is Associated with Its Modulation of the P2X7 Receptor in Human Monocytes
DOI: 10.1021/acs.jnatprod.0c00138

Review of Progress in the Chemistry of Organic Natural Products
DOI: 10.1021/acs.jnatprod.0c00356

Selective Chlorophyll Removal Method to “Degreen” Botanical Extracts
DOI: 10.1021/acs.jnatprod.0c00005

Streptomyces albogriseolus SY67903 Produces Eunicellin Diterpenoids Structurally Similar to Terpenes of the Gorgonian Muricella sibogae, the Bacterial Source
DOI: 10.1021/acs.jnatprod.0c00147



Journal of Proteome Research

***

Deciphering the Proteome Dynamics during Development of Neurons Derived from Induced Pluripotent Stem Cells
Open Access Through ACS AuthorChoice
DOI: 10.1021/acs.jproteome.0c00070

His-Tagged Peptidiscs Enable Affinity Purification of the Membrane Proteome for Downstream Mass Spectrometry Analysis
DOI: 10.1021/acs.jproteome.0c00022

Stable Isotope-Triggered Offset Fragmentation Allows Massively Multiplexed Target Profiling on Quadrupole-Orbitrap Mass Spectrometers
DOI: 10.1021/acs.jproteome.0c00065

Physiological Tau Interactome in Brain and Its Link to Tauopathies
DOI: 10.1021/acs.jproteome.0c00137

Relative and Quantitative Phosphoproteome Analysis of Macrophages in Response to Infection by Virulent and Avirulent Mycobacteria Reveals a Distinct Role of the Cytosolic RNA Sensor RIG-I in Mycobacterium tuberculosis Pathogenesis
DOI: 10.1021/acs.jproteome.9b00895



Journal of the American Chemical Society

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Nickel-Catalyzed Cross-Electrophile Coupling of Aryl Chlorides with Primary Alkyl Chlorides
DOI: 10.1021/jacs.0c02673

Chemical Equivalent of Arene Monooxygenases: Dearomative Synthesis of Arene Oxides and Oxepines
DOI: 10.1021/jacs.0c02724

Nucleophilic (Radio)Fluorination of Redox-Active Esters via Radical-Polar Crossover Enabled by Photoredox Catalysis
DOI: 10.1021/jacs.0c03125

Synthesis of Pyrroles through the CuH-Catalyzed Coupling of Enynes and Nitriles
DOI: 10.1021/jacs.0c03859

Organophotoredox Hydrodefluorination of Trifluoromethylarenes with Translational Applicability to Drug Discovery
Open Access Through ACS AuthorChoice
DOI: 10.1021/jacs.0c03881



Journal of the American Society for Mass Spectrometry

***

Kenneth G. Standing (April 3, 1925–March 21, 2019)
DOI: 10.1021/jasms.0c00049

Don’t Stop Thinking about Tomorrow
DOI: 10.1021/jasms.0c00170

Solvent Adducts in Ion Mobility Spectrometry: Toward an Alternative Reaction Probe for Thermometer Ions
DOI: 10.1021/jasms.0c00108

Direct Analysis of Doping Agents in Raw Urine Using Hydrophobic Paper Spray Mass Spectrometry
DOI: 10.1021/jasms.0c00063

Quantitative Proteomic Analysis of MARC-145 Cells Infected with a Mexican Porcine Reproductive and Respiratory Syndrome Virus Strain Using a Label-Free Based DIA Approach
DOI: 10.1021/jasms.0c00134



Langmuir

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Hofmeister Series for Metal-Cation–RNA Interactions: The Interplay of Binding Affinity and Exchange Kinetics
Open Access Through ACS AuthorChoice
DOI: 10.1021/acs.langmuir.0c00851

Effects of Amino Acids on Iron-Silicate Chemical Garden Precipitation
Open Access Through ACS AuthorChoice
DOI: 10.1021/acs.langmuir.0c00502

Compression, Rupture, and Puncture of Model Membranes at the Molecular Scale
DOI: 10.1021/acs.langmuir.0c00247

Colloidal Photonic Assemblies for Colorful Radiative Cooling
DOI: 10.1021/acs.langmuir.0c00051

Surfactant-Free One-Pot Synthesis of Homogeneous Trimetallic PtNiCu Nanoparticles with Size Control by Using Glycine
DOI: 10.1021/acs.langmuir.0c00665



Macromolecules

***

The Beauty of Branching in Polymer Science
DOI: 10.1021/acs.macromol.0c00286

Tough Supramolecular Elastomer via Entropy-Driven Hydrogen Bonds between Vicinal Diols
DOI: 10.1021/acs.macromol.9b02639

Harnessing Strained Disulfides for Photocurable Adaptable Hydrogels
DOI: 10.1021/acs.macromol.0c00604

Precise Control of Molecular Weight and Stereospecificity in Lewis Pair Polymerization of Semifluorinated Methacrylates: Mechanistic Studies and Stereocomplex Formation
DOI: 10.1021/acs.macromol.0c00553

Polyethylene Containing Triblock Copolymers Synthesized by Post-polymerization Functionalization
DOI: 10.1021/acs.macromol.0c00627



Molecular Pharmaceutics

***

Emerging Biomolecular Testing to Assess the Risk of Mortality from COVID-19 Infection
Open Access Through ACS AuthorChoice
This article is part of the Nanomedicines Beyond Cancer special issue.
DOI: 10.1021/acs.molpharmaceut.0c00371

Transdermal Drug Delivery for Hair Regrowth
DOI: 10.1021/acs.molpharmaceut.0c00041

TLR7/8 Agonist-Loaded Nanoparticles Augment NK Cell-Mediated Antibody-Based Cancer Immunotherapy
DOI: 10.1021/acs.molpharmaceut.0c00271

Combined Application of Albumin-Binding [177Lu]Lu-PSMA-ALB-56 and Fast-Cleared PSMA Inhibitors: Optimization of the Pharmacokinetics
DOI: 10.1021/acs.molpharmaceut.0c00199

Intranasal Delivery and Transfection of mRNA Therapeutics in the Brain Using Cationic Liposomes
DOI: 10.1021/acs.molpharmaceut.0c00170



Nano Letters

***

Nanobowl-Supported Liposomes Improve Drug Loading and Delivery
Open Access Through ACS Editors’ Choice
DOI: 10.1021/acs.nanolett.0c00495

Deconvoluting Lipid Nanoparticle Structure for Messenger RNA Delivery
Open Access Through ACS AuthorChoice
DOI: 10.1021/acs.nanolett.0c01386

One-Dimensional Edge Transport in Few-Layer WTe2
Open Access Through ACS AuthorChoice
DOI: 10.1021/acs.nanolett.0c00658

Exciting Journey from the 0D to the 2D Nanoworld
DOI: 10.1021/acs.nanolett.0c01077

Hybrid Biodegradable Nanomotors through Compartmentalized Synthesis
Open Access Through ACS AuthorChoice
DOI: 10.1021/acs.nanolett.0c01268



Organic Letters

***

Electrochemical Ruthenium-Catalyzed C–H Hydroxylation of Amine Derivatives in Aqueous Acid
Open Access Through ACS Editors’ Choice
DOI: 10.1021/acs.orglett.0c01313

Designing Homogeneous Copper-Free Sonogashira Reaction through a Prism of Pd–Pd Transmetalation
Open Access Through ACS AuthorChoice
DOI: 10.1021/acs.orglett.0c01227

Total Synthesis of (±)-Sceptrin
Open Access Through ACS AuthorChoice
DOI: 10.1021/acs.orglett.0c01381

A General One-Pot Protocol for Hindered N-Alkyl Azaheterocycles from Tertiary Carboxylic Acids
DOI: 10.1021/acs.orglett.0c01254

Hidden Boron Catalysis: Nucleophile-Promoted Decomposition of HBpin
DOI: 10.1021/acs.orglett.0c01168



Organic Process Research & Development

***

Some Items of Interest to Process R&D Chemists and Engineers
DOI: 10.1021/acs.oprd.0c00197

Potential Explosion Hazards Associated with the Autocatalytic Thermal Decomposition of Dimethyl Sulfoxide and Its Mixtures
DOI: 10.1021/acs.oprd.0c00159

A Taste of Current French Organic Chemistry
This article is part of the A Taste of Current French Organic Chemistry special issue.
DOI: 10.1021/acs.oprd.0c00095

Continuous Process for Preparing the Difluoromethylating Reagent [(DMPU)2Zn(CF2H) 2] and Improved Synthesis of the ICHF2 Precursor
DOI: 10.1021/acs.oprd.0c00089

Applications of Flow Chemistry in the Pharmaceutical Industry—Highlights of the Recent Patent Literature
DOI: 10.1021/acs.oprd.0c00156



Organometallics

***

Synthesis, Structures, and Electronic Properties of O- and S-Heterocyclic Carbene Complexes of Iridium, Copper, Silver, and Gold
Open Access Through ACS AuthorChoice
DOI: 10.1021/acs.organomet.0c00066

Organometallic Chemistry for Enabling Carbon Dioxide Utilization
This article is part of the Organometallic Chemistry for Enabling Carbon Dioxide Utilization special issue.
DOI: 10.1021/acs.organomet.0c00229

An Update on Multiple Bonding between Heavier Main Group Elements: The Importance of Pauli Repulsion, Charge-Shift Character, and London Dispersion Force Effects
DOI: 10.1021/acs.organomet.0c00200

Nickel-Catalyzed Alkyne Cyclotrimerization Assisted by a Hemilabile Acceptor Ligand: A Computational Study
Open Access Through ACS AuthorChoice
DOI: 10.1021/acs.organomet.0c00172

One-Electron Reduction of Ti(IV) Complex by Dialkylaluminum(I) Anion Giving the Ti(III) Species
DOI: 10.1021/acs.organomet.0c00177



The Journal of Organic Chemistry

***

Recent Advances in Synthetic Methods for Radioiodination
Open Access Through ACS Editors’ Choice
DOI: 10.1021/acs.joc.0c00644

One-Pot Suzuki-Hydrogenolysis Protocol for the Modular Synthesis of 2,5-Diaryltetrazoles
Open Access Through ACS AuthorChoice
DOI: 10.1021/acs.joc.0c00807

Total Synthesis of Cinnamodial-Based Dimer (−)-Capsicodendrin
DOI: 10.1021/acs.joc.0c00740

Cp*Co(III)-Catalyzed Ketone-Directed ortho-C–H Activation for the Synthesis of Indene Derivatives
DOI: 10.1021/acs.joc.0c00727

Metal-Free Synthesis of Phenol-Aryl Selenides via Dehydrogenative C–Se Coupling of Aryl Selenoxides with Phenols
DOI: 10.1021/acs.joc.0c00792



The Journal of Physical Chemistry A

***

Memorial Viewpoint for William L. Hase
DOI: 10.1021/acs.jpca.0c03827

Novel Computer Architectures and Quantum Chemistry
DOI: 10.1021/acs.jpca.0c02249

Ring-Current Maps for Benzenoids: Comparisons, Contradictions, and a Versatile Combinatorial Model
Open Access Through ACS AuthorChoice
DOI: 10.1021/acs.jpca.0c02748

Correlation of Photoluminescence and Structural Morphologies at the Individual Nanoparticle Level
Open Access Through ACS AuthorChoice
This article is part of the Time-Resolved Microscopy virtual special issue.
DOI: 10.1021/acs.jpca.0c02340

Highly Conjugated, Fused-Ring, Quadrupolar Organic Chromophores with Large Two-Photon Absorption Cross-Sections in the Near-Infrared
DOI: 10.1021/acs.jpca.0c02572



The Journal of Physical Chemistry B

***

Theoretical Insights into the Excited State Decays of a Donor–Acceptor Dyad: Is the Twisted and Rehybridized Intramolecular Charge-Transfer State Involved?
DOI: 10.1021/acs.jpcb.0c02455

Universal and Nonuniversal Aspects of Electrostatics in Aqueous Nanoconfinement
Open Access Through ACS AuthorChoice
DOI: 10.1021/acs.jpcb.0c01967

Quantifying Protein-Protein Interactions in Molecular Simulations
Open Access Through ACS AuthorChoice
DOI: 10.1021/acs.jpcb.9b11802

Remarkable Levels of 15N Polarization Delivered through SABRE into Unlabeled Pyridine, Pyrazine, or Metronidazole Enable Single Scan NMR Quantification at the mM Level
Open Access Through ACS AuthorChoice
DOI: 10.1021/acs.jpcb.0c02583

RNAPosers: Machine Learning Classifiers for Ribonucleic Acid–Ligand Poses
DOI: 10.1021/acs.jpcb.0c02322



The Journal of Physical Chemistry C

***

Substrate-Dependent Exciton Diffusion and Annihilation in Chemically Treated MoS2 and WS2
DOI: 10.1021/acs.jpcc.0c04000

Luminescence Line Broadening of CdSe Nanoplatelets and Quantum Dots for Application in w-LEDs
Open Access Through ACS AuthorChoice
DOI: 10.1021/acs.jpcc.0c03048

Elucidation of the Active Sites for Monodisperse FePt and Pt Nanocrystal Catalysts for p-WSe2 Photocathodes
Open Access Through ACS AuthorChoice
DOI: 10.1021/acs.jpcc.0c01288

How the Nature of the Alkali Metal Cations Influences the Double Layer Capacitance of Cu, Au and Pt Single Crystal Electrodes
DOI: 10.1021/acs.jpcc.0c01715

Structural Stability of Physisorbed Air-Oxidized Decanethiols on Au(111)
Open Access Through ACS AuthorChoice
DOI: 10.1021/acs.jpcc.0c02806



The Journal of Physical Chemistry Letters

***

Self-Healing Dyes—Keeping the Promise?
Open Access Through ACS Editors’ Choice
DOI: 10.1021/acs.jpclett.9b03833

In Silico Exploration of the Molecular Mechanism of Clinically Oriented Drugs for Possibly Inhibiting SARS-CoV-2’s Main Protease
Open Access Through ACS AuthorChoice
DOI: 10.1021/acs.jpclett.0c00994

Novel Coronavirus Polymerase and Nucleotidyl-transferase Structures: Potential to Target New Outbreaks
Open Access Through ACS AuthorChoice
DOI: 10.1021/acs.jpclett.0c00571

Resolving Spectral Mismatch Errors for Perovskite Solar Cells in Commercial Class AAA Solar Simulators
Open Access Through ACS AuthorChoice
DOI: 10.1021/acs.jpclett.0c00355

Combining Graphics Processing Units, Simplified Time-Dependent Density Functional Theory, and Finite-Difference Couplings to Accelerate Nonadiabatic Molecular Dynamics
Open Access Through ACS AuthorChoice
DOI: 10.1021/acs.jpclett.0c00320

Browse the Most Read Articles of April 2020

There are lots of different ways to look at the reach of an article. You can look at citations, Altmetric Attention Scores, awards, and more. One way to consider the influence of an article is just by looking at how many people chose to read it. To that end, we’ve compiled lists of the five most-read chemistry articles from each ACS Publications journal in April 2020, including research, reviews, perspectives, and editorial pieces. These lists were not chosen by the journal’s editors and should not be taken as a “best of” list, but as another perspective on where the chemistry community allocated their attention.

Click on your favorite journal below to see their most-read articles of the month.

Sign up to get this list in your inbox every month.


Accounts of Chemical Research

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When Light Meets Nitrogen-Centered Radicals: From Reagents to Catalysts
DOI: 10.1021/acs.accounts.0c00090

Mechanisms of Nickel-Catalyzed Coupling Reactions and Applications in Alkene Functionalization
DOI: 10.1021/acs.accounts.0c00032

First Accounts: The Capstone of a Tenure Tour
DOI: 10.1021/acs.accounts.0c00227

Small-Molecule Modulators of Toll-like Receptors
DOI: 10.1021/acs.accounts.9b00631

Molecular Packing: Another Key Point for the Performance of Organic and Polymeric Optoelectronic Materials
DOI: 10.1021/acs.accounts.0c00060



ACS Applied Bio Materials

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Rational Design of Near-Infrared Cyanine-Based Fluorescent Probes for Rapid In Vivo Sensing Cysteine
DOI: 10.1021/acsabm.0c00260

Update to Our Reader, Reviewer, and Author Communities—April 2020
DOI: 10.1021/acsabm.0c00433

Small-Molecule Probe for Sensing Serum Albumin with Consequential Self-Assembly as a Fluorescent Organic Nanoparticle for Bioimaging and Drug-Delivery Applications
DOI: 10.1021/acsabm.0c00146

Molecular Architectonics of Cyclic Dipeptide Amphiphiles and Their Application in Drug Delivery
DOI: 10.1021/acsabm.0c00340

Nanostructured Polymer Monoliths for Biomedical Delivery Applications
DOI: 10.1021/acsabm.0c00228



ACS Applied Electronic Materials

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Compliance Current-Controlled Conducting Filament Formation in Tantalum Oxide-Based RRAM Devices with Different Top Electrodes
DOI: 10.1021/acsaelm.0c00128

Update to Our Reader, Reviewer, and Author Communities—April 2020
DOI: 10.1021/acsaelm.0c00317

Research Progress and Prospect of Triboelectric Nanogenerators as Self-Powered Human Body Sensors
DOI: 10.1021/acsaelm.0c00022

Large-Area Cesium Lead Bromide Perovskite Light-Emitting Diodes Realized by Incorporating a Hybrid Additive
DOI: 10.1021/acsaelm.0c00102

Interface of Electrogenic Bacteria and Reduced Graphene Oxide: Energetics and Electron Transport
DOI: 10.1021/acsaelm.0c00057



ACS Applied Energy Materials

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Resonant Metagratings for Spectral and Angular Control of Light for Colored Rooftop Photovoltaics
Open Access Through ACS AuthorChoice
DOI: 10.1021/acsaem.0c00027

Update to Our Reader, Reviewer, and Author Communities—April 2020
DOI: 10.1021/acsaem.0c00879

Spatial- and Time-Resolved Mapping of Interfacial Polarization and Polar Nanoregions at Nanoscale in High-Energy-Density Ferroelectric Nanocomposites
DOI: 10.1021/acsaem.0c00131

Capacity Limiting Effects for Freestanding, Monolithic TiO2 Nanotube Electrodes with High Mass Loadings
Open Access Through ACS AuthorChoice
DOI: 10.1021/acsaem.0c00298

Electrochemical Properties and Crystal Structure of Li+/H+ Cation-Exchanged LiNiO2
Open Access Through ACS AuthorChoice
DOI: 10.1021/acsaem.0c00602



ACS Applied Materials & Interfaces

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Update to Our Reader, Reviewer, and Author Communities—April 2020
DOI: 10.1021/acsami.0c07158

Nanomaterial Development, Characterization, and Integration Strategies for Chemical Warfare Defense
DOI: 10.1021/acsami.0c03654

Electroplasticization of Liquid Crystal Polymer Networks
Open Access Through ACS AuthorChoice
DOI: 10.1021/acsami.0c01748

Iodine Capture Using Zr-Based Metal–Organic Frameworks (Zr-MOFs): Adsorption Performance and Mechanism
DOI: 10.1021/acsami.0c02129

Double-Sided Graphene Oxide Encapsulated Silver Nanowire Transparent Electrode with Improved Chemical and Electrical Stability
Open Access Through ACS AuthorChoice
DOI: 10.1021/acsami.0c03587



ACS Applied Nano Materials

***

Update to Our Reader, Reviewer, and Author Communities—April 2020
DOI: 10.1021/acsanm.0c01057

Electrodeposited Metal Organic Framework toward Excellent Hydrogen Sensing in an Ionic Liquid
DOI: 10.1021/acsanm.0c00503

Extended Metal–Organic Frameworks on Diverse Supports as Electrode Nanomaterials for Electrochemical Energy Storage
DOI: 10.1021/acsanm.0c00702

Boosting the Er3+ 1.5 μm Luminescence in CsPbCl3 Perovskite Nanocrystals for Photonic Devices Operating at Telecommunication Wavelengths
DOI: 10.1021/acsanm.0c00701

Cubic AgBiS2 Colloidal Nanocrystals for Solar Cells
Open Access Through ACS AuthorChoice
DOI: 10.1021/acsanm.9b02443



ACS Applied Polymer Materials

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Ranking Plasticizers for Polymers with Atomistic Simulations: PVT, Mechanical Properties, and the Role of Hydrogen Bonding in Thermoplastic Starch
Open Access Through ACS AuthorChoice
DOI: 10.1021/acsapm.0c00191

Update to Our Reader, Reviewer, and Author Communities—April 2020
DOI: 10.1021/acsapm.0c00410

Tissue-Mimetic Dielectric Actuators: Free-Standing, Stable, and Solvent-Free
DOI: 10.1021/acsapm.0c00141

Dynamic Covalent Polyurethane Networks with Excellent Property and Cross-Link Density Recovery after Recycling and Potential for Monomer Recovery
DOI: 10.1021/acsapm.0c00378

Mechanically Strong Polyurea/Polyurethane-Cross-Linked Alginate Aerogels
DOI: 10.1021/acsapm.0c00162



ACS Biomaterials Science & Engineering

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Manual Versus Microfluidic-Assisted Nanoparticle Manufacture: Impact of Silk Fibroin Stock on Nanoparticle Characteristics
Open Access Through ACS AuthorChoice
DOI: 10.1021/acsbiomaterials.0c00202

Update to Our Reader, Reviewer, and Author Communities—April 2020
DOI: 10.1021/acsbiomaterials.0c00580

Artificial Cell-Penetrating Peptide Containing Periodic α-Aminoisobutyric Acid with Long-Term Internalization Efficiency in Human and Plant Cells
Open Access Through ACS AuthorChoice
DOI: 10.1021/acsbiomaterials.0c00182

Rolling Circle Amplification-Based Polyvalent Molecular Beacon Probe-Assisted Signal Amplification Strategies for Sensitive Detection of B16 Cells
DOI: 10.1021/acsbiomaterials.0c00288

Tofu-Incorporated Hydrogels for Potential Bone Regeneration
DOI: 10.1021/acsbiomaterials.9b01997



ACS Catalysis

***

Updates on the Roadmap for Photocatalysis
DOI: 10.1021/acscatal.0c01204

Dual Cobalt and Photoredox Catalysis Enabled Intermolecular Oxidative Hydrofunctionalization
DOI: 10.1021/acscatal.0c01209

Light-Mediated Asymmetric Aliphatic C–H Alkylation with Hydrogen Atom Transfer Catalyst and Chiral Phosphoric Acid
DOI: 10.1021/acscatal.0c00610

Nickel-Catalyzed Chemodivergent 1,1-Difunctionalization of Unactivated α-Olefins with Alkynyl Electrophiles and B2pin2
DOI: 10.1021/acscatal.0c00898

Expanding Ligand Space: Preparation, Characterization, and Synthetic Applications of Air-Stable, Odorless Di-tert-alkylphosphine Surrogates
DOI: 10.1021/acscatal.0c01414



ACS Central Science

***

Photoswitchable gRNAs for Spatiotemporally Controlled CRISPR-Cas-Based Genomic Regulation
Open Access Through ACS AuthorChoice
DOI: 10.1021/acscentsci.9b01093

An Epoxide Intermediate in Glycosidase Catalysis
Open Access Through ACS AuthorChoice
DOI: 10.1021/acscentsci.0c00111

Late-Stage Diversification of Natural Products
Open Access Through ACS AuthorChoice
DOI: 10.1021/acscentsci.9b00916

Light-Activatable, 2,5-Disubstituted Tetrazoles for the Proteome-wide Profiling of Aspartates and Glutamates in Living Bacteria
Open Access Through ACS AuthorChoice
DOI: 10.1021/acscentsci.9b01268

Unbiased Identification of the Liposome Protein Corona using Photoaffinity-based Chemoproteomics
Open Access Through ACS AuthorChoice
DOI: 10.1021/acscentsci.9b01222



ACS Chemical Biology

***

Fighting the Coronavirus Outbreak
Open Access Through ACS AuthorChoice
DOI: 10.1021/acschembio.0c00175

Cyanopyrrolidine Inhibitors of Ubiquitin Specific Protease 7 Mediate Desulfhydration of the Active-Site Cysteine
DOI: 10.1021/acschembio.0c00031

Two-Stage Strategy for Development of Proteolysis Targeting Chimeras and its Application for Estrogen Receptor Degraders
DOI: 10.1021/acschembio.0c00140

Dual-Activatable Cell Tracker for Controlled and Prolonged Single-Cell Labeling
Open Access Through ACS AuthorChoice
DOI: 10.1021/acschembio.0c00208

Update to Our Reader, Reviewer, and Author Communities—April 2020
DOI: 10.1021/acschembio.0c00302



ACS Chemical Health & Safety

***

Starting and Sustaining a Laboratory Safety Team (LST)
Open Access Through ACS Editors’ Choice
DOI: 10.1021/acs.chas.0c00016

A Hazard Index for Chemical Logistic Warehouses with Modified Flammability Rating by Machine Learning Methods
DOI: 10.1021/acs.chas.9b00026

Barrier Banding: A Concept for Safety Solutions Utilizing Control Banding Principles
DOI: 10.1021/acs.chas.9b00021

Update to Our Reader, Reviewer, and Author Communities—April 2020
DOI: 10.1021/acs.chas.0c00042



ACS Chemical Neuroscience

***

SARS-CoV-2: Olfaction, Brain Infection, and the Urgent Need for Clinical Samples Allowing Earlier Virus Detection
Open Access Through ACS AuthorChoice
DOI: 10.1021/acschemneuro.0c00172

Neurological Insights of COVID-19 Pandemic
Open Access Through ACS AuthorChoice
DOI: 10.1021/acschemneuro.0c00201

Letter to the Editor Regarding the Viewpoint “Evidence of the COVID-19 Virus Targeting the CNS: Tissue Distribution, Host–Virus Interaction, and Proposed Neurotropic Mechanism”
Open Access Through ACS AuthorChoice
DOI: 10.1021/acschemneuro.0c00174

Updates on What ACS Reported: Emerging Evidences of COVID-19 with Nervous System Involvement
Open Access Through ACS AuthorChoice
DOI: 10.1021/acschemneuro.0c00181

Physiological and Pathological Roles of Cdk5: Potential Directions for Therapeutic Targeting in Neurodegenerative Disease
Open Access Through ACS Editors’ Choice
DOI: 10.1021/acschemneuro.0c00096



ACS Combinatorial Science

***

Update to Our Reader, Reviewer, and Author Communities—April 2020
DOI: 10.1021/acscombsci.0c00061

Immobilized Carbodiimide Assisted Flow Combinatorial Protocol to Facilitate Amide Coupling and Lactamization
DOI: 10.1021/acscombsci.0c00001

Ce(OTf)3-Catalyzed Multicomponent Reaction of Alkynyl Carboxylic Acids, tert-Butyl Isocyanide, and Azides for the Assembly of Triazole–Oxazole Derivatives
DOI: 10.1021/acscombsci.0c00012

Magnetic Bead-Immobilized Mammalian Cells Are Effective Targets to Enrich Ligand-Displaying Yeast
DOI: 10.1021/acscombsci.0c00036

Optimized Multimetal Sensitized Phosphor for Enhanced Red Up-Conversion Luminescence by Machine Learning
DOI: 10.1021/acscombsci.0c00035



ACS Earth and Space Chemistry

***

COVID-19 and the Air We Breathe
Open Access Through ACS AuthorChoice
DOI: 10.1021/acsearthspacechem.0c00093

Virtual Special Issue: New Advances in Organic Aerosol Chemistry
This article is part of the New Advances in Organic Aerosol Chemistry special issue.
DOI: 10.1021/acsearthspacechem.0c00052

Complex Organic Molecules (COMs) in Star-Forming Regions: A Virtual Special Issue
This article is part of the Complex Organic Molecules (COMs) in Star-Forming Regions special issue.
DOI: 10.1021/acsearthspacechem.0c00043

Update to Our Reader, Reviewer, and Author Communities—April 2020
DOI: 10.1021/acsearthspacechem.0c00104

Site-Specific Mechanisms in OH-Initiated Organic Aerosol Heterogeneous Oxidation Revealed by Isomer-Resolved Molecular Characterization
DOI: 10.1021/acsearthspacechem.0c00082



ACS Energy Letters

***

Direction for Commercialization of O3-Type Layered Cathodes for Sodium-Ion Batteries
DOI: 10.1021/acsenergylett.0c00597

Self-Healing Janus Interfaces for High-Performance LAGP-Based Lithium Metal Batteries
DOI: 10.1021/acsenergylett.0c00542

Isotopically Selective Quantification by UPLC-MS of Aqueous Ammonia at Submicromolar Concentrations Using Dansyl Chloride Derivatization
DOI: 10.1021/acsenergylett.0c00496

Shallow and Deep Trap State Passivation for Low-Temperature Processed Perovskite Solar Cells
DOI: 10.1021/acsenergylett.0c00596

Energy Spotlight: New Advances in Metal Halide Perovskites
DOI: 10.1021/acsenergylett.0c00687



ACS Infectious Diseases

***

Update to Our Reader, Reviewer, and Author Communities—April 2020
DOI: 10.1021/acsinfecdis.0c00218

Infectious Disease Research in China
This article is part of the Infectious Disease Research in China special issue.
DOI: 10.1021/acsinfecdis.0c00220

A Potent Host Defense Peptide Triggers DNA Damage and Is Active against Multidrug-Resistant Gram-Negative Pathogens
DOI: 10.1021/acsinfecdis.0c00051

Radiosynthesis and Biodistribution of 18F-Linezolid in Mycobacterium tuberculosis-Infected Mice Using Positron Emission Tomography
DOI: 10.1021/acsinfecdis.9b00473

Structure-Guided Molecular Grafting of a Complex Broadly Neutralizing Viral Epitope
DOI: 10.1021/acsinfecdis.0c00008



ACS Macro Letters

***

100th Anniversary of Macromolecular Science Viewpoint: Macromolecular Materials for Additive Manufacturing
DOI: 10.1021/acsmacrolett.0c00200

Ultrahigh Molecular Weight Hydrophobic Acrylic and Styrenic Polymers through Organic-Phase Photoiniferter-Mediated Polymerization
DOI: 10.1021/acsmacrolett.0c00203

100th Anniversary of Macromolecular Science Viewpoint: Recent Advances and Opportunities for Mixed Ion and Charge Conducting Polymers
DOI: 10.1021/acsmacrolett.0c00037

100th Anniversary of Macromolecular Science Viewpoint: Modeling and Simulation of Macromolecules with Hydrogen Bonds: Challenges, Successes, and Opportunities
DOI: 10.1021/acsmacrolett.0c00134

Update to Our Reader, Reviewer, and Author Communities—April 2020
DOI: 10.1021/acsmacrolett.0c00310



ACS Materials Letters

***

Interview with Professor Ben Zhong Tang
DOI: 10.1021/acsmaterialslett.0c00111

Celebrating the 20th Anniversary of Aggregation-Induced Emission with Research Highlights from ACS Journals
DOI: 10.1021/acsmaterialslett.0c00117

Area-Selective Atomic Layer Deposition of Two-Dimensional WS2 Nanolayers
Open Access Through ACS AuthorChoice
DOI: 10.1021/acsmaterialslett.0c00093

Rational Design of Circularly Polarized Luminescent Aggregation-Induced Emission Luminogens (AIEgens): Promoting the Dissymmetry Factor and Emission Efficiency Synchronously
DOI: 10.1021/acsmaterialslett.0c00063

Update to Our Reader, Reviewer, and Author Communities—April 2020
DOI: 10.1021/acsmaterialslett.0c00159



ACS Medicinal Chemistry Letters

***

Can Drug Repositioning Work as a Systematical Business Model?
DOI: 10.1021/acsmedchemlett.0c00122

PROTAC Compounds Targeting α-Synuclein Protein for Treating Neurogenerative Disorders: Alzheimer’s and Parkinson’s Diseases
DOI: 10.1021/acsmedchemlett.0c00192

Selective Covalent Targeting of Mutated EGFR(T790M) with Chlorofluoroacetamide-Pyrimidines
DOI: 10.1021/acsmedchemlett.9b00574

Discovery of a Potent Dual Inhibitor of Wild-Type and Mutant Respiratory Syncytial Virus Fusion Proteins
DOI: 10.1021/acsmedchemlett.0c00008

Rationally Designed Covalent BCL6 Inhibitor That Targets a Tyrosine Residue in the Homodimer Interface
DOI: 10.1021/acsmedchemlett.0c00111



ACS Nano

***

Aerosol Filtration Efficiency of Common Fabrics Used in Respiratory Cloth Masks
Open Access Through ACS AuthorChoice
DOI: 10.1021/acsnano.0c03252

Dual-Functional Plasmonic Photothermal Biosensors for Highly Accurate Severe Acute Respiratory Syndrome Coronavirus 2 Detection
Open Access Through ACS AuthorChoice
DOI: 10.1021/acsnano.0c02439

Rapid Detection of COVID-19 Causative Virus (SARS-CoV-2) in Human Nasopharyngeal Swab Specimens Using Field-Effect Transistor-Based Biosensor
Open Access Through ACS AuthorChoice
DOI: 10.1021/acsnano.0c02823

COVID-19: A Call for Physical Scientists and Engineers
Open Access Through ACS AuthorChoice
DOI: 10.1021/acsnano.0c02618

Computational Design of ACE2-Based Peptide Inhibitors of SARS-CoV-2
Open Access Through ACS AuthorChoice
DOI: 10.1021/acsnano.0c02857



ACS Omega

***

Contribution of Organofluorine Compounds to Pharmaceuticals
Open Access Through ACS AuthorChoice
DOI: 10.1021/acsomega.0c00830

Computational Investigation on the p53–MDM2 Interaction Using the Potential of Mean Force Study
Open Access Through ACS AuthorChoice
DOI: 10.1021/acsomega.9b03372

Mesoporous Octahedron-Shaped Tricobalt Tetroxide Nanoparticles for Photocatalytic Degradation of Toxic Dyes
Open Access Through ACS AuthorChoice
DOI: 10.1021/acsomega.9b03998

In Situ Zirconia: A Superior Reinforcing Filler for High-Performance Nitrile Rubber Composites
Open Access Through ACS AuthorChoice
DOI: 10.1021/acsomega.9b03495

Ferrocene-Supported Compartmental Ligands for the Assembly of 3d/4f Complexes
Open Access Through ACS AuthorChoice
DOI: 10.1021/acsomega.0c00654



ACS Pharmacology & Translational Science

***

Auranofin-Based Analogues Are Effective Against Clear Cell Renal Carcinoma In Vivo and Display No Significant Systemic Toxicity
DOI: 10.1021/acsptsci.9b00107

Strategic Moves of “Superbugs” Against Available Chemical Scaffolds: Signaling, Regulation, and Challenges
DOI: 10.1021/acsptsci.0c00005

Update to Our Reader, Reviewer, and Author Communities—April 2020
DOI: 10.1021/acsptsci.0c00037

Editorial for Advances in G Protein-Coupled Receptor Signal Transduction Special Issue
This article is part of the Advances in GPCR Signal Transduction special issue.
DOI: 10.1021/acsptsci.0c00029

Spatial Distribution Profiles of Emtricitabine, Tenofovir, Efavirenz, and Rilpivirine in Murine Tissues Following In Vivo Dosing Correlate with Their Safety Profiles in Humans
DOI: 10.1021/acsptsci.0c00015



ACS Photonics

***

Goodbye Juan José Sáenz (1960–2020): A Bright Scientific Mind, an Unusually Prolific Friend, and a Family Man
DOI: 10.1021/acsphotonics.0c00526

Update to Our Reader, Reviewer, and Author Communities—April 2020
DOI: 10.1021/acsphotonics.0c00628

Monochromatic X-ray Source Based on Scattering from a Magnetic Nanoundulator
Open Access Through ACS AuthorChoice
DOI: 10.1021/acsphotonics.0c00121

Plasmon-Mediated Coherent Superposition of Discrete Excitons under Strong Exciton–Plasmon Coupling in Few-Layer MoS2 at Room Temperature
DOI: 10.1021/acsphotonics.0c00233

Directional off-Normal Photon Streaming from Hybrid Plasmon-Emitter Coupled Metasurfaces
DOI: 10.1021/acsphotonics.0c00196



ACS Sensors

***

Update to Our Reader, Reviewer, and Author Communities—April 2020
DOI: 10.1021/acssensors.0c00796

Remembering NJ
DOI: 10.1021/acssensors.0c00660

CUT-LAMP: Contamination-Free Loop-Mediated Isothermal Amplification Based on the CRISPR/Cas9 Cleavage
DOI: 10.1021/acssensors.0c00034

Obituary: Nongjian Tao 1963–2020
DOI: 10.1021/acssensors.0c00663

Paper-Based Device for the Facile Colorimetric Determination of Lithium Ions in Human Whole Blood
DOI: 10.1021/acssensors.9b02218



ACS Sustainable Chemistry & Engineering

***

Earth Day Reflections: Hope Amid the Pandemic
Open Access Through ACS AuthorChoice
DOI: 10.1021/acssuschemeng.0c02596

Expectations for Manuscripts on Catalysis in ACS Sustainable Chemistry & Engineering
DOI: 10.1021/acssuschemeng.0c01677

Update to Our Reader, Reviewer, and Author Communities—April 2020
DOI: 10.1021/acssuschemeng.0c02908

An Earth Day Message: Earthrise
DOI: 10.1021/acssuschemeng.0c02170

Design of Sustainable Materials by Cross-linking a Biobased Epoxide with Keratin and Lignin
DOI: 10.1021/acssuschemeng.0c01759



ACS Symposium Series

***

Discovery of Nuclear Magnetic Resonance: Rabi, Purcell, and Bloch
DOI: 10.1021/bk-2020-1349.ch001

Preface
DOI: 10.1021/bk-2020-1349.pr001

Excitement about Relaxation: Relaxation and the History of Electron Paramagnetic Resonance
DOI: 10.1021/bk-2020-1349.ch011

Introduction to Forensic Proteomics
DOI: 10.1021/bk-2019-1339.ch001

R. Linn Belford: A Scientific Journey from Understanding EPR Spectra to Building High Field EPR Instrumentation
DOI: 10.1021/bk-2020-1349.ch010



ACS Synthetic Biology

***

Update to Our Reader, Reviewer, and Author Communities—April 2020
DOI: 10.1021/acssynbio.0c00216

A Modular Method for Directing Protein Self-Assembly
DOI: 10.1021/acssynbio.9b00504

Blue-Light-Switchable Bacterial Cell–Cell Adhesions Enable the Control of Multicellular Bacterial Communities
DOI: 10.1021/acssynbio.0c00054

Genome-Wide CRISPRi-Based Identification of Targets for Decoupling Growth from Production
DOI: 10.1021/acssynbio.9b00143

Engineering Prokaryotic Transcriptional Activator XylR as a Xylose-Inducible Biosensor for Transcription Activation in Yeast
DOI: 10.1021/acssynbio.0c00122



Analytical Chemistry

***

Rapid and Sensitive Detection of anti-SARS-CoV-2 IgG, Using Lanthanide-Doped Nanoparticles-Based Lateral Flow Immunoassay
Open Access Through ACS AuthorChoice
DOI: 10.1021/acs.analchem.0c00784

Measuring Remodeling of the Lipid Environment Surrounding Membrane Proteins with Lipid Exchange and Native Mass Spectrometry
DOI: 10.1021/acs.analchem.0c00786

Dual-Mode of Fluorescence Turn-On and Wavelength-Shift for Methylamine Gas Sensing Based on Space-Confined Growth of Methylammonium Lead Tribromide Perovskite Nanocrystals
DOI: 10.1021/acs.analchem.0c00698

Benchmarking the Orbitrap Tribrid Eclipse for Next Generation Multiplexed Proteomics
DOI: 10.1021/acs.analchem.9b05685

The Addition of Executive Editors: A Change for the Better!
DOI: 10.1021/acs.analchem.0c01566



Biochemistry

***

Why Are Lopinavir and Ritonavir Effective against the Newly Emerged Coronavirus 2019? Atomistic Insights into the Inhibitory Mechanisms
Open Access Through ACS AuthorChoice
DOI: 10.1021/acs.biochem.0c00160

A Novel Cryo-EM Structure Enables Development of Selective Cannabinoid Receptor Drugs
DOI: 10.1021/acs.biochem.0c00263

Distinct Handoff Mechanism for TBP-TATA DNA Engagement Revealed by SAGA Structures
DOI: 10.1021/acs.biochem.0c00190

Allosteric Control of Enzyme Activity: From Ancient Origins to Recent Gene-Editing Technologies
DOI: 10.1021/acs.biochem.0c00275

Parsing Molecules for Drug Discovery
DOI: 10.1021/acs.biochem.0c00278



Bioconjugate Chemistry

***

Site-Specific Antibody Conjugation Strategy to Functionalize Virus-Based Nanoparticles
DOI: 10.1021/acs.bioconjchem.0c00118

Efficient Sortase-Mediated Ligation Using a Common C-Terminal Fusion Tag
DOI: 10.1021/acs.bioconjchem.0c00156

Design Strategies and Medicinal Applications of Metal-Peptidic Bioconjugates
DOI: 10.1021/acs.bioconjchem.0c00152

Two-Photon and Multicolor Fluorogenic Bioorthogonal Probes Based on Tetrazine-Conjugated Naphthalene Fluorophores
DOI: 10.1021/acs.bioconjchem.0c00197

Supramolecular β-Sheet Forming Peptide Conjugated with Near-Infrared Chromophore for Selective Targeting, Imaging, and Dysfunction of Mitochondria
DOI: 10.1021/acs.bioconjchem.0c00153



Biomacromolecules

***

Multivalency Enables Dynamic Supramolecular Host–Guest Hydrogel Formation
Open Access Through ACS AuthorChoice
DOI: 10.1021/acs.biomac.0c00148

Control over Imidazoquinoline Immune Stimulation by pH-Degradable Poly(norbornene) Nanogels
Open Access Through ACS AuthorChoice
DOI: 10.1021/acs.biomac.0c00205

Update to Our Reader, Reviewer, and Author Communities—April 2020
DOI: 10.1021/acs.biomac.0c00585

Reactive Polymer Targeting dsRNA as Universal Virus Detection Platform with Enhanced Sensitivity
DOI: 10.1021/acs.biomac.0c00379

Structures and Antifouling Properties of Self-Assembled Zwitterionic Peptide Monolayers: Effects of Peptide Charge Distributions and Divalent Cations
DOI: 10.1021/acs.biomac.0c00062



Chemical Research in Toxicology

***

The Ah Receptor: Adaptive Metabolism, Ligand Diversity, and the Xenokine Model
Open Access through ACS AuthorChoice
DOI: 10.1021/acs.chemrestox.9b00476

Update to Our Reader, Reviewer, and Author Communities—April 2020
DOI: 10.1021/acs.chemrestox.0c00151

Neurotoxicology of Nanomaterials
DOI: 10.1021/acs.chemrestox.0c00050

Perspective on Health Effects of Endocrine Disruptors with a Focus on Data Gaps
DOI: 10.1021/acs.chemrestox.9b00529

Binding and Metabolism of Brominated Flame Retardant β-1,2-Dibromo-4-(1,2-dibromoethyl)cyclohexane in Human Microsomal P450 Enzymes: Insights from Computational Studies
DOI: 10.1021/acs.chemrestox.0c00076



Chemical Reviews

***

Chemical Synthesis of Single Atomic Site Catalysts
DOI: 10.1021/acs.chemrev.9b00818

Electrically Conductive Metal–Organic Frameworks
Open Access through ACS AuthorChoice
DOI: 10.1021/acs.chemrev.9b00766

The Spectroscopy of Nitrogenases
Open Access through ACS AuthorChoice
DOI: 10.1021/acs.chemrev.9b00650

Microstructural and Dynamical Heterogeneities in Ionic Liquids
Open Access through ACS AuthorChoice
DOI: 10.1021/acs.chemrev.9b00693

Update to Our Reader, Reviewer, and Author Communities—April 2020
DOI: 10.1021/acs.chemrev.0c00326



Chemistry of Materials

***

Snapshots of Life—Early Career Materials Scientists Managing in the Midst of a Pandemic
Open Access through ACS AuthorChoice
DOI: 10.1021/acs.chemmater.0c01624

Lithium Diffusion in Niobium Tungsten Oxide Shear Structures
Open Access through ACS Editors’ Choice
DOI: 10.1021/acs.chemmater.0c00483

Response to “Particle Size Is a Primary Determinant for Sigmoidal Kinetics of Nanoparticle Formation: A “Disproof” of the Finke–Watzky (F-W) Nanoparticle Nucleation and Growth Mechanism”
DOI: 10.1021/acs.chemmater.0c00780

Coordination-Driven Self-Assembly in Polymer–Inorganic Hybrid Materials†
DOI: 10.1021/acs.chemmater.0c00851

A Selective Toolbox for Nanofabrication
DOI: 10.1021/acs.chemmater.0c00838



Crystal Growth & Design

***

van der Waals Epitaxy of Earth-Abundant Zn3P2 on Graphene for Photovoltaics
Open Access through ACS AuthorChoice
DOI: 10.1021/acs.cgd.0c00125

Isoreticular Three-Dimensional Kagome Metal–Organic Frameworks with Open-Nitrogen-Donor Pillars for Selective Gas Adsorption
DOI: 10.1021/acs.cgd.0c00352

Cationic Metal–Organic Frameworks Based on Linear Zwitterionic Ligands for Cr2O72– and Ammonia Sensing
DOI: 10.1021/acs.cgd.0c00247

Size Control of the MOF NU-1000 through Manipulation of the Modulator/Linker Competition
DOI: 10.1021/acs.cgd.9b01590

Update to Our Reader, Reviewer, and Author Communities—April 2020
DOI: 10.1021/acs.cgd.0c00543



Energy & Fuels

***

Virtual Special Issue of 7th Sino-Australian Symposium on Advanced Coal and Biomass Utilisation Technologies
DOI: 10.1021/acs.energyfuels.0c00979

Update to Our Reader, Reviewer, and Author Communities—April 2020
DOI: 10.1021/acs.energyfuels.0c01273

Chemical Looping Conversion of Gaseous and Liquid Fuels for Chemical Production: A Review
Open Access through ACS Editors’ Choice
DOI: 10.1021/acs.energyfuels.0c01006

FeP Nanocatalyst with Preferential [010] Orientation Boosts the Hydrogen Evolution Reaction in Polymer-Electrolyte Membrane Electrolyzer
DOI: 10.1021/acs.energyfuels.0c00793

Mineral Interfaces and Oil Recovery: A Microscopic View on Surface Reconstruction, Organic Modification, and Wettability Alteration of Carbonates
DOI: 10.1021/acs.energyfuels.0c00118



Environmental Science & Technology

***

Letter to the Editor Regarding: “An Imperative Need for Research on the Role of Environmental Factors in Transmission of Novel Coronavirus (COVID-19)” —Secondhand and Thirdhand Smoke As Potential Sources of COVID-19
DOI: 10.1021/acs.est.0c02041

Letter to the Editor: Wastewater-Based Epidemiology Can Overcome Representativeness and Stigma Issues Related to COVID-19
Open Access through ACS AuthorChoice
DOI: 10.1021/acs.est.0c02172

What Roles Are Terrestrial Plants Playing in Global Microplastic Cycling?
DOI: 10.1021/acs.est.0c01009

Update to Our Reader, Reviewer, and Author Communities—April 2020
DOI: 10.1021/acs.est.0c02442

Bacterial Diversity Controls Transformation of Wastewater-Derived Organic Contaminants in River-Simulating Flumes
Open Access through ACS AuthorChoice
DOI: 10.1021/acs.est.9b06928



Environmental Science & Technology Letters

***

Update to Our Reader, Reviewer, and Author Communities—April 2020
DOI: 10.1021/acs.estlett.0c00316

Determining Hosts of Antibiotic Resistance Genes: A Review of Methodological Advances
DOI: 10.1021/acs.estlett.0c00202

Thermal Stability and Decomposition of Perfluoroalkyl Substances on Spent Granular Activated Carbon
DOI: 10.1021/acs.estlett.0c00114

Simultaneous Determination of Multiple Classes of Phenolic Compounds in Human Urine: Insight into Metabolic Biomarkers of Occupational Exposure to E-Waste
DOI: 10.1021/acs.estlett.0c00187

Enhanced Degradation of Perfluorocarboxylic Acids (PFCAs) by UV/Sulfite Treatment: Reaction Mechanisms and System Efficiencies at pH 12
DOI: 10.1021/acs.estlett.0c00236



Industrial & Engineering Chemistry Research

***

CO2 Capture and Utilization Editorial
This article is part of the Carbon Capture and Utilization special issue.
DOI: 10.1021/acs.iecr.0c01643

Structural Features of Zirconium-Based Metal–Organic Frameworks Affecting Radiolytic Stability
DOI: 10.1021/acs.iecr.9b06820

Concentrated Carbon Dioxide (CO2) from Diluted Sources through Continuous Temperature Swing Adsorption (TSA)
Open Access through ACS AuthorChoice
DOI: 10.1021/acs.iecr.9b06177

Construction of Large-Pore Crystalline Covalent Organic Framework as High-Performance Adsorbent for Rhodamine B Dye Removal
DOI: 10.1021/acs.iecr.0c00304

3D-Printed ZIF-8 Monoliths for Biobutanol Recovery
DOI: 10.1021/acs.iecr.0c00453



Inorganic Chemistry

***

Electronic Structure and Magnetic Properties of a Titanium(II) Coordination Complex
Open Access through ACS Editors’ Choice
DOI: 10.1021/acs.inorgchem.0c00311

The Art of Synthesis: From a (Social) Distance
DOI: 10.1021/acs.inorgchem.0c01090

Artificial Iron Proteins: Modeling the Active Sites in Non-Heme Dioxygenases
DOI: 10.1021/acs.inorgchem.9b03791

An Iron Pincer Complex in Four Oxidation States
DOI: 10.1021/acs.inorgchem.0c00355

Enhanced Electrochemical CO2 Reduction by a Series of Molecular Rhenium Catalysts Decorated with Second-Sphere Hydrogen-Bond Donors
DOI: 10.1021/acs.inorgchem.0c00154



Journal of Agricultural and Food Chemistry

***

Rhizosphere Microbiome Assembly and Its Impact on Plant Growth
DOI: 10.1021/acs.jafc.0c00073

Development of Novel Pesticides Targeting Insect Chitinases: A Minireview and Perspective
DOI: 10.1021/acs.jafc.0c00888

Analysis of Protein Oxidation in Food and Feed Products
DOI: 10.1021/acs.jafc.0c00711

Discovery of Novel Pyrazole–Quinazoline-2,4-dione Hybrids as 4-Hydroxyphenylpyruvate Dioxygenase Inhibitors
DOI: 10.1021/acs.jafc.0c00051

Update to Our Reader, Reviewer, and Author Communities—April 2020
DOI: 10.1021/acs.jafc.0c02498



Journal of Chemical & Engineering Data

***

Vapor–Liquid Equilibrium of Ionic Liquid 7-Methyl-1,5,7-triazabicyclo[4.4.0]dec-5-enium Acetate and Its Mixtures with Water
Open Access through ACS AuthorChoice
DOI: 10.1021/acs.jced.9b01039

Application of GaInSn Liquid Metal Alloy Replacing Mercury in a Phase Equilibrium Cell: Vapor Pressures of Toluene, Hexylbenzene, and 2-Ethylnaphthalene
Open Access through ACS AuthorChoice
DOI: 10.1021/acs.jced.9b01208

Dissociation Constant (pKa) and Thermodynamic Properties of 1,4-Bis(3-aminopropyl) Piperazine, 1,3-Bis(aminomethyl) Cyclohexane, Tris(2-aminoethyl) Amine, and 1-Amino-4-methyl Piperazine: Study of the Protonation Mechanism Using the Density Function Theory
DOI: 10.1021/acs.jced.9b00702

Update to Our Reader, Reviewer, and Author Communities—April 2020
DOI: 10.1021/acs.jced.0c00349

Hydrodeoxygenation Model Compounds γ-Heptalactone and γ-Nonalactone: Density from 293 to 473 K and H2 Solubility from 479 to 582 K
Open Access through ACS AuthorChoice
DOI: 10.1021/acs.jced.0c00087



Journal of Chemical Education

***

Journal of Chemical Education Call for Papers: Special Issue on Insights Gained While Teaching Chemistry in the Time of COVID-19
DOI: 10.1021/acs.jchemed.0c00378

Transition to eBook Provision: A Commentary on the Preferences and Adoption of eBooks by Chemistry Undergraduates
DOI: 10.1021/acs.jchemed.9b01157

Exploring Everyday Chemistry: The Effectiveness of an Organic Chemistry Massive Open Online Course as an Education and Outreach Tool
Open Access through ACS AuthorChoice
DOI: 10.1021/acs.jchemed.9b01151

Visualizing 3D Molecular Structures Using an Augmented Reality App
DOI: 10.1021/acs.jchemed.9b01033

John C. Warner (the Elder)’s Vision of Chemistry and Responsible Citizenship, with an Update by John C. Warner (the Younger)
DOI: 10.1021/acs.jchemed.0c00219



Journal of Chemical Information and Modeling

***

A Community Letter Regarding Sharing Bimolecular Simulation Data for COVID-19
Open Access through ACS AuthorChoice
DOI: 10.1021/acs.jcim.0c00319

Fast Identification of Possible Drug Treatment of Coronavirus Disease -19 (COVID-19) Through Computational Drug Repurposing Study
Open Access through ACS AuthorChoice
DOI: 10.1021/acs.jcim.0c00179

Structure- and Ligand-Based Virtual Screening on DUD-E+: Performance Dependence on Approximations to the Binding Pocket
Open Access through ACS AuthorChoice
DOI: 10.1021/acs.jcim.0c00115

AMPL: A Data-Driven Modeling Pipeline for Drug Discovery
Open Access through ACS AuthorChoice
DOI: 10.1021/acs.jcim.9b01053

The Synthesizability of Molecules Proposed by Generative Models
DOI: 10.1021/acs.jcim.0c00174



Journal of Chemical Theory and Computation

***

Kernel-Based Machine Learning for Efficient Simulations of Molecular Liquids
Open Access through ACS AuthorChoice
DOI: 10.1021/acs.jctc.9b01256

Reduced Common Molecular Orbital Basis for Nonorthogonal Configuration Interaction
Open Access through ACS AuthorChoice
DOI: 10.1021/acs.jctc.9b01144

Update to Our Reader, Reviewer, and Author Communities—April 2020
DOI: 10.1021/acs.jctc.0c00394

Theoretical Infrared Spectra: Quantitative Similarity Measures and Force Fields
Open Access through ACS AuthorChoice
DOI: 10.1021/acs.jctc.0c00126

The ONIOM/PMM Model for Effective Yet Accurate Simulation of Optical and Chiroptical Spectra in Solution: Camphorquinone in Methanol as a Case Study
Open Access through ACS AuthorChoice
DOI: 10.1021/acs.jctc.0c00124



Journal of Medicinal Chemistry

***

Identification of the Clinical Development Candidate MRTX849, a Covalent KRASG12C Inhibitor for the Treatment of Cancer
Open Access through ACS AuthorChoice
DOI: 10.1021/acs.jmedchem.9b02052

Achieving In Vivo Target Depletion through the Discovery and Optimization of Benzimidazolone BCL6 Degraders
Open Access through ACS AuthorChoice
DOI: 10.1021/acs.jmedchem.9b02076

Current and Future Roles of Artificial Intelligence in Medicinal Chemistry Synthesis
Open Access through ACS AuthorChoice
DOI: 10.1021/acs.jmedchem.9b02120

Metabolism and Bioactivation: It’s Time to Expect the Unexpected
DOI: 10.1021/acs.jmedchem.0c00026

Positional Analogue Scanning: An Effective Strategy for Multiparameter Optimization in Drug Design
DOI: 10.1021/acs.jmedchem.9b02092



Journal of Natural Products

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Cannabis Inflorescence for Medical Purposes: USP Considerations for Quality Attributes
Open Access through ACS AuthorChoice
DOI: 10.1021/acs.jnatprod.9b01200

Dysidealactams and Dysidealactones: Sesquiterpene Glycinyl-Lactams, Imides, and Lactones from a Dysidea sp. Marine Sponge Collected in Southern Australia
DOI: 10.1021/acs.jnatprod.0c00041

Dipleosporalones A and B, Dimeric Azaphilones from a Marine-Derived Pleosporales sp. Fungus
DOI: 10.1021/acs.jnatprod.0c00132

Irijimasides A–E, Macrolide Glycosides from an Okeania sp. Marine Cyanobacterium
DOI: 10.1021/acs.jnatprod.0c00042

Unprecedented Quassinoids from Eurycoma longifolia: Biogenetic Evidence and Antifeedant Effects
DOI: 10.1021/acs.jnatprod.0c00244



Journal of Proteome Research

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Quality Control and Outlier Detection of Targeted Mass Spectrometry Data from Multiplex Protein Panels
Open Access through ACS Editors’ Choice
DOI: 10.1021/acs.jproteome.9b00854

Fast and Highly Efficient Affinity Enrichment of Azide-A-DSBSO Cross-Linked Peptides
Open Access through ACS AuthorChoice
DOI: 10.1021/acs.jproteome.0c00003

Comprehensive Examination of the Mouse Lung Metabolome Following Mycobacterium tuberculosis Infection Using a Multiplatform Mass Spectrometry Approach
Open Access through ACS AuthorChoice
DOI: 10.1021/acs.jproteome.9b00868

A Bayesian Null Interval Hypothesis Test Controls False Discovery Rates and Improves Sensitivity in Label-Free Quantitative Proteomics
DOI: 10.1021/acs.jproteome.9b00796

Update to Our Reader, Reviewer, and Author Communities—April 2020
DOI: 10.1021/acs.jproteome.0c00263



Journal of the American Chemical Society

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Update to Our Reader, Reviewer, and Author Communities—April 2020
Open Access through ACS AuthorChoice
DOI: 10.1021/jacs.0c04253

Synthesis of β-Phenethylamines via Ni/Photoredox Cross-Electrophile Coupling of Aliphatic Aziridines and Aryl Iodides
DOI: 10.1021/jacs.0c01724

Nickel/Photoredox-Catalyzed Methylation of (Hetero)aryl Chlorides Using Trimethyl Orthoformate as a Methyl Radical Source
DOI: 10.1021/jacs.0c02805

Asymmetric Total Synthesis of (−)-Spirochensilide A
DOI: 10.1021/jacs.0c02522

Amino Acid Schiff Base Bearing Benzophenone Imine As a Platform for Highly Congested Unnatural α-Amino Acid Synthesis
DOI: 10.1021/jacs.0c02707



Journal of the American Society for Mass Spectrometry

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Finding a Silver Lining in a Dark Cloud
DOI: 10.1021/jasms.0c00124

Top-Down Analysis of In-Source HDX of Native Protein Ions
DOI: 10.1021/jasms.9b00149

Update to Our Reader, Reviewer, and Author Communities—April 2020
DOI: 10.1021/jasms.0c00135

Structural Elucidation of Ether Glycerophospholipids Using Gas-Phase Ion/Ion Charge Inversion Chemistry
DOI: 10.1021/jasms.0c00025

Ion Mobility and Gas-Phase Covalent Labeling Study of the Structure and Reactivity of Gaseous Ubiquitin Ions Electrosprayed from Aqueous and Denaturing Solutions
DOI: 10.1021/jasms.9b00138



Langmuir

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Antifouling Polymer Brushes via Oxygen-Tolerant Surface-Initiated PET-RAFT
Open Access through ACS AuthorChoice
DOI: 10.1021/acs.langmuir.9b03536

Gold Nanocluster Extracellular Vesicle Supraparticles: Self-Assembled Nanostructures for Three- Open Access through ACS AuthorChoice
Dimensional Uptake Visualization
DOI: 10.1021/acs.langmuir.9b03479

Structure Determination of Hen Egg-White Lysozyme Aggregates Adsorbed to Lipid/Water and Air/Water Interfaces
Open Access through ACS AuthorChoice
DOI: 10.1021/acs.langmuir.9b03826

Gold Nanocluster Extracellular Vesicle Supraparticles: Self-Assembled Nanostructures for Three-Dimensional Uptake Visualization
Open Access through ACS AuthorChoice
DOI: 10.1021/acs.langmuir.9b03479

Practical MOF Nanoarchitectonics: New Strategies for Enhancing the Processability of MOFs for Practical Applications
DOI: 10.1021/acs.langmuir.0c00236



Macromolecules

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Fabrication of Bioinspired Hydrogels: Challenges and Opportunities
DOI: 10.1021/acs.macromol.0c00238

Bioerodible Hydrogels Based on Photopolymerized Poly(ethylene glycol)-co-poly(α-hydroxy acid) Diacrylate Macromers
DOI: 10.1021/acs.macromol.0c00030

The ABCs of Block Polymers
DOI: 10.1021/acs.macromol.0c00174

Retraction of “N-Phenylglycine as a Versatile Photoinitiator under Near-UV LED”
DOI: 10.1021/acs.macromol.0c00700

4-Carboalkoxylated Polyvalerolactones from Malic Acid: Tough and Degradable Polyesters
DOI: 10.1021/acs.macromol.0c00212



Molecular Pharmaceutics

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Update to Our Reader, Reviewer, and Author Communities—April 2020
DOI: 10.1021/acs.molpharmaceut.0c00420

Analysis of Triterpenoid Saponins Reveals Insights into Structural Features Associated with Potent Protein Drug Enhancement Effects
DOI: 10.1021/acs.molpharmaceut.0c00216

Tumor Microenvironment Stimuli-Responsive Nanoparticles for Programmed Anticancer Drug Delivery
DOI: 10.1021/acs.molpharmaceut.9b01189

Anti-HER2 Affibody-Conjugated Photosensitizer for Tumor Targeting Photodynamic Therapy
DOI: 10.1021/acs.molpharmaceut.9b01247

Synthesis and Analysis of 64Cu-Labeled GE11-Modified Polymeric Micellar Nanoparticles for EGFR-Targeted Molecular Imaging in a Colorectal Cancer Model
DOI: 10.1021/acs.molpharmaceut.9b01043



Nano Letters

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Photoactivatable Prodrug-Backboned Polymeric Nanoparticles for Efficient Light-Controlled Gene Delivery and Synergistic Treatment of Platinum-Resistant Ovarian Cancer
DOI: 10.1021/acs.nanolett.9b04981

Metallic Sandwiched-Aerogel Hybrids Enabling Flexible and Stretchable Intelligent Sensor
DOI: 10.1021/acs.nanolett.0c00372

Colloidal Synthesis of Ternary Copper Halide Nanocrystals for High-Efficiency Deep-Blue Light-Emitting Diodes with a Half-Lifetime above 100 h
DOI: 10.1021/acs.nanolett.0c00513

Thermogalvanic Hydrogel for Synchronous Evaporative Cooling and Low-Grade Heat Energy Harvesting
DOI: 10.1021/acs.nanolett.0c00800

Two Birds with One Stone: FeS2@C Yolk–Shell Composite for High-Performance Sodium-Ion Energy Storage and Electromagnetic Wave Absorption
DOI: 10.1021/acs.nanolett.0c00789



Organic Letters

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Postulated Biogenesis-Guided Total Synthesis and Structural Revision of 2,18-seco-Lankacidinol A
Open Access through ACS Editors’ Choice
DOI: 10.1021/acs.orglett.0c00993

C–H Functionalization of Benzothiazoles via Thiazol-2-yl-phosphonium Intermediates
DOI: 10.1021/acs.orglett.0c00882

Site-Selective C–H Functionalization–Sulfination Sequence to Access Aryl Sulfonamides
Open Access through ACS AuthorChoice
DOI: 10.1021/acs.orglett.0c00982

Additions of Aldehyde-Derived Radicals and Nucleophilic N-Alkylindoles to Styrenes by Photoredox Catalysis
Open Access through ACS AuthorChoice
DOI: 10.1021/acs.orglett.0c01182

Transamidation for the Synthesis of Primary Amides at Room Temperature
DOI: 10.1021/acs.orglett.0c00958



Organic Process Research & Development

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Safety Case Study. Intrinsic Instability of Concentrated Solutions of Alcoholic Hydrogen Chloride: Potential Hazards Associated with Methanol
Open Access through ACS Editors’ Choice
DOI: 10.1021/acs.oprd.0c00034

Some Items of Interest to Process R&D Chemists and Engineers
DOI: 10.1021/acs.oprd.0c00127

An Economical Route to Lamivudine Featuring a Novel Strategy for Stereospecific Assembly
Open Access through ACS AuthorChoice
DOI: 10.1021/acs.oprd.0c00083

Green Chemistry Articles of Interest to the Pharmaceutical Industry
DOI: 10.1021/acs.oprd.0c00154

Reductive Amination Bicarbonate Quench: Gas-Evolving Waste Stream Near-Miss Investigation
DOI: 10.1021/acs.oprd.0c00085



Organometallics

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Potentiostatically Controlled Olefin Metathesis
Open Access through ACS Editors’ Choice
DOI: 10.1021/acs.organomet.0c00052

Oxidative Addition of Aryl Halides to a Triphosphine Ni(0) Center to Form Pentacoordinate Ni(II) Aryl Species
Open Access through ACS AuthorChoice
DOI: 10.1021/acs.organomet.0c00060

Pioneers and Influencers in Organometallic Chemistry: Dr. Patricia Watson and the Molecular Dance of M–C and C–H Bonds
DOI: 10.1021/acs.organomet.0c00225

To Bind or Not to Bind: Mechanistic Insights into C–CO2 Bond Formation with Late Transition Metals
Open Access through ACS AuthorChoice
DOI: 10.1021/acs.organomet.0c00090

C–F Bond Activation of a Perfluorinated Ligand Leading to Nucleophilic Fluorination of an Organic Electrophile
Open Access through ACS Editors’ Choice
DOI: 10.1021/acs.organomet.0c00176



The Journal of Organic Chemistry

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Sulfinamide Synthesis Using Organometallic Reagents, DABSO, and Amines
Open Access through ACS AuthorChoice
DOI: 10.1021/acs.joc.0c00334

Benzylic Hydroperoxidation via Visible-Light-Induced Csp3–H Activation
DOI: 10.1021/acs.joc.0c00385

Impact of Cyanine Conformational Restraint in the Near-Infrared Range
DOI: 10.1021/acs.joc.0c00236

Derivatization of Amino Acids and Peptides via Photoredox-Mediated Conjugate Addition
DOI: 10.1021/acs.joc.0c00635

Toward FAIRness and a User-Friendly Repository for Supporting NMR Data
DOI: 10.1021/acs.joc.0c00800



The Journal of Physical Chemistry A

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Role of Nonvalence States in the Ultrafast Dynamics of Isolated Anions
Open Access through ACS Editors’ Choice
DOI: 10.1021/acs.jpca.0c01260

Viewpoints on the 2020 Pacific Conference on Spectroscopy and Dynamics
DOI: 10.1021/acs.jpca.0c02425

Wide-Field Fluorescence Lifetime Imaging of Single Molecules
DOI: 10.1021/acs.jpca.0c01513

Update to Our Reader, Reviewer, and Author Communities—April 2020
DOI: 10.1021/acs.jpca.0c03467

Comment on “Correct Symmetry Treatment for X + X Reactions Prevents Large Errors in Predicted Isotope Enrichment”
Open Access through ACS AuthorChoice
DOI: 10.1021/acs.jpca.0c00210



The Journal of Physical Chemistry B

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Update to Our Reader, Reviewer, and Author Communities—April 2020
DOI: 10.1021/acs.jpcb.0c03495

Unraveling the Structural Dynamics of an Enzyme Encapsulated within a Metal–Organic Framework
DOI: 10.1021/acs.jpcb.0c02145

Hydrogen Bonding in the Liquid State of Linear Alcohols: Molecular Dynamics and Thermodynamics
DOI: 10.1021/acs.jpcb.0c01199

Temperature-Dependent Spectroscopic Ellipsometry of Thin Polymer Films
DOI: 10.1021/acs.jpcb.9b11863

Role of Asp190 in the Phosphorylation of the Antibiotic Kanamycin Catalyzed by the Aminoglycoside Phosphotransferase Enzyme: A Combined QM:QM and MD Study
DOI: 10.1021/acs.jpcb.0c01604



The Journal of Physical Chemistry C

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Metal Hydrides and Related Materials. Energy Carriers for Novel Hydrogen and Electrochemical Storage
DOI: 10.1021/acs.jpcc.0c01806

Molecular Recognition and Band Alignment in 3D Covalent Organic Frameworks for Cocrystalline Organic Photovoltaics
DOI: 10.1021/acs.jpcc.0c00087

Magnetism-Vanishing Stabilizes the Pyrite-Type 3d Transition Metal Peroxides at High Pressures
DOI: 10.1021/acs.jpcc.0c00054

Properties of α-Brass Nanoparticles. 1. Neural Network Potential Energy Surface
DOI: 10.1021/acs.jpcc.0c00559

Chemical States of Water Molecules Distributed Inside a Proton Exchange Membrane of a Running Fuel Cell Studied by Operando Coherent Anti-Stokes Raman Scattering Spectroscopy
Open Access through ACS AuthorChoice
DOI: 10.1021/acs.jpcc.0c00347



The Journal of Physical Chemistry Letters

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Pb-Based Perovskite Solar Cells and the Underlying Pollution behind Clean Energy: Dynamic Leaching of Toxic Substances from Discarded Perovskite Solar Cells
Open Access through ACS Editors’ Choice
DOI: 10.1021/acs.jpclett.0c00503

Excited State Dynamics of Thermally Activated Delayed Fluorescence from an Excited State Intramolecular Proton Transfer System
Open Access through ACS AuthorChoice
DOI: 10.1021/acs.jpclett.0c00498

Chiral Molecules and the Spin Selectivity Effect
Open Access through ACS AuthorChoice
DOI: 10.1021/acs.jpclett.0c00474

Directional Light Emission from Layered Metal Halide Perovskite Crystals
DOI: 10.1021/acs.jpclett.0c00901

Facets and Defects in Perovskite Nanocrystals for Photocatalytic CO2 Reduction
DOI: 10.1021/acs.jpclett.0c01088